A5101574783- Sarcoma Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Tryptophan and brain disorders
- Musculoskeletal synovial abnormalities and treatments
- Neuroblastoma Research and Treatments
- Medicinal Plants and Bioactive Compounds
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects of Natural Compounds
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Ziziphus Jujuba Studies and Applications
- Macrophage Migration Inhibitory Factor
- Oral and Maxillofacial Pathology
- Esophageal Cancer Research and Treatment
- Invertebrate Immune Response Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Hepatitis C virus research
- Biological and pharmacological studies of plants
- Gestational Trophoblastic Disease Studies
- Insect Utilization and Effects
- Chromatography in Natural Products
- Vascular Tumors and Angiosarcomas
- Essential Oils and Antimicrobial Activity
- Lung Cancer Treatments and Mutations
- Neurofibromatosis and Schwannoma Cases
Tianjin Medical University Cancer Institute and Hospital
2008-2024
Tianjin Medical University
2011-2023
National Clinical Research
2023
Qingdao Mental Health Center
2021
Qiqihar Medical University
2015
First Affiliated Hospital of Zhengzhou University
2014
The University of Texas MD Anderson Cancer Center
2011
Tampere University
2011
Cincinnati Children's Hospital Medical Center
2011
Sun Yat-sen University
2008
Malignant peripheral nerve sheath tumor (MPNST) is a rare sarcoma that lacks effective therapeutic strategies. We gain insight into the most recurrent genetically altered pathways with purpose of scanning possible targets.We conducted microarray-based comparative genomic hybridization profiling two cohorts primary MPNST tissue samples including 25 patients treated at The University Texas MD Anderson Cancer Center and 26 from Tianjin Hospital. Immunohistochemistry (IHC) cell biology detection...
Abstract Recent studies revealed that folic acid deficiency (FD) increased the likelihood of stroke and aggravated brain injury after focal cerebral ischaemia. The microglia‐mediated inflammatory response plays a crucial role in complicated pathologies lead to ischaemic injury. However, whether FD is involved activation microglia neuroinflammation experimental underlying mechanism still unclear. aim present study was assess modulates Notch1/nuclear factor kappa B (NF‐κB) pathway enhances...
Abstract Objectives To investigate the protective effect of catalpol on cerebral ischaemia/reperfusion (CI/R) injury in gerbils and further explore underlying mechanism. Methods A gerbil model CI/R was prepared by bilateral common carotid occlusion for 10 min followed 6 h reperfusion. Catalpol (5, or 20 mg/kg per day) injected intraperitoneally 3 days before occlusion. Stroke index measured during The contents endogenous neuropeptides, endothelin-1 (ET-1) calcitonin gene-related peptide...
Autism spectrum disorder (ASD) is a complex neuropsychiatric disorder. A number of genetic risk loci have been identified for ASD from genome-wide association studies (GWAS); however, their target genes in relevant tissues and cell types remain to be investigated. The frontal cortex key region the human brain communication cognitive function. To identify contributing potential dysfunction patients, we took an silico approach integrating multi-omics data. We first found with expression tissue...
Purpose: In this study, we sought to test the hypothesis that oxidative stress injury in ischemic brains and H2O2-treated mouse neuroblastoma Neuro-2a cells (N2a) was related STAT3 activation.Materials methods: Rat middle cerebral artery occlusion (MCAO) model were used investigate relationship between activation.Results: 8-Hydroxy-2′-deoxyguanosine (8-OHdG) content protein phosphorylation level significantly increased after ischemia-reperfusion. H2O2 treatment inhibited cell viability,...
The histogenesis of the hepatic sarcoma and its association with hamartoma is not well understood. We hereby present a Chinese patient angiosarcoma arising from an adult mesenchymal liver. A 33-yr-old woman was diagnosed eight years ago presented epigastric distention recently. Now she admitted to our hospital some unusual features: (a) this in mid-twenties, (b) tumor occupied whole liver most importantly (c) appeared 8 after diagnosis hamartoma. Based on case reports, may develop angiosarcoma.
In the study, high-speed counter-current chromatography was used for separation and purification of magnoflorine, spinosin, 6‴-feruloyspinosin from Ziziphi Spinosae Semen. With n-butanol-ethyl acetate-water (2:3:5, v/v) as optimum solvent system, about 75 mg 110 40 were isolated 0.5 g crude extract Z. Semen, with purity 95.7, 97.2, 96.4%, respectively. The chemical structures identified by MS NMR spectroscopy. addition, antidepressant activity components evaluated PC12 cells injury model...
To explore the effect of transcranial stimulation on therapeutic and immune function patients with post-stroke depression (PSD). Methods Selection in September 2020-April 2021 diagnosis 70 PSD as research object, 35 were randomly divided into control group intervention given conventional treatment, basis application magnetic compare curative two groups after treatment cycle effects function. Results After levels DA, NE, 5-HT 2 significantly increased, those observation higher than (P <...
Accumulating data provide evidence that autophagy contributes to programmed cell death (PCD) under certain circumstances. Immunohistochemistry and real-time PCR were performed investigate the correlation expression of autophagy-related proteins LC3 Atg4B linearly patterned necrosis (LPPCN) in melanoma. LPPCN was recently reported be a special PCD, which is similar neither apoptosis nor conventional commonly observed tumoral tissues. The mechanism involved remains unclear. Our showed...
We investigated the anxiolytic effects Agaricus brasiliensis extract (AbSE) on ischemia-induced anxiety using plus-maze test and social interaction test. The animals were treated orally with AbSE (4, 8, 10 mg/kg/d, respectively) for 30 d, followed by middle cerebral artery occlusion-induced ischemia. Levels of noradrenaline, dopamine, serotonin in cortex rats, as well oxidative stress plasma corticosterone levels analyzed, respectively. rota-rod was carried out to exclude any false positive...
Context. Ziziphi Spinosae Semen (ZSS) is a well-known Chinese herbal medicine used in the treatment of depression and anxiety China. ZSS contains several active components, such as alkaloids, saponins, flavonoids. Objective. This study aimed to explore synergistic effect alkaloids saponins from alleviating mouse model. Materials Methods. Modeling with chronic unpredictable stimuli. Pharmacodynamic methods (tail suspension test forced swimming test) were evaluate antidepressant effects...
e13518 Background: Mismatch repair deficiency (dMMR) assessed by microsatellite instability (MSI) or immunohistochemistry (IHC) is a feature of Lynch syndrome, major hereditary colorectal cancer (CRC). Chinese syndrome criteria was proposed based on the decreasing family numbers: In pedigree, it should have at least 2 CRCs, and them are first-degree relatives each other. Besides, any one following be met: 1) 1 CRC multiple primary synchronous/metachronous carcinoma/adenoma; 2) diagnosed...
A central paradigm of non-equilibrium physics concerns the dynamics heterogeneity and disorder, impacting processes ranging from behavior glasses1 to emergent functionality active matter. Understanding these complex mesoscopic systems requires probing microscopic trajectories associated with irreversible processes, role fluctuations entropy growth, timescales on which responses are ultimately maintained. Approaches that illuminate in model may enable a more general understanding other...