A5100643495- Alzheimer's disease research and treatments
- Obstructive Sleep Apnea Research
- Physiological and biochemical adaptations
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience of respiration and sleep
- Autophagy in Disease and Therapy
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Bioactive Compounds
- Infant Nutrition and Health
- Cancer, Hypoxia, and Metabolism
- Catalysis for Biomass Conversion
- Fungal Biology and Applications
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Probiotics and Fermented Foods
- Gut microbiota and health
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Glycation End Products research
- Retinal Diseases and Treatments
- Lignin and Wood Chemistry
- Organic Light-Emitting Diodes Research
- Antioxidant Activity and Oxidative Stress
Zhejiang University
2022-2025
Southeast University
2020-2025
Sir Run Run Shaw Hospital
2023-2025
Jiangnan University
2006-2024
Feed Research Institute
2024
China Agricultural University
2024
Huazhong University of Science and Technology
2021-2024
Hebei Normal University
2022-2024
Jilin University
2002-2024
People's Liberation Army 401 Hospital
2024
Two types of novel deep eutectic solvents with different functional groups were designed for highly efficient dissolution lignin.
While melatonin is known to have protective effects in mitochondria-related diseases, aging, and neurodegenerative disorders, there poor understanding of the treatment on mitophagy Alzheimer's disease (AD). We used proteomic analysis investigate underlying molecular mechanisms oral hippocampus 4-month-old wild-type mice versus age-matched 5 × FAD mice, an animal model AD. showed disordered mitochondrial dysfunction as revealed by increased mtDNA, marker proteins MDA production, decreased...
Polyhydroquinoline (PHQ) are the unsymmetrical Hantzsch derivatives of 1,4-dihydropyridines with several biological applications. In this work, twenty-five (3-27) new Schiff's base polyhydroquinoline hydrazide were synthesized in excellent to good yields by a multi-component reaction. The structures products (1-27) deduced help spectroscopic techniques, such as 1H-, 13C -NMR, and HR-ESI-MS. tested for their antibacterial vitro calcium -channel-blocking (CCB) potentials using agar-well...
The electromagnetic characteristics of a single-phase permanent magnet linear oscillation actuator are analyzed by the finite element method. Firstly, basic structure and operation principle introduced. internal stator slot arc tooth used to reduce detent force. According fields, field equation is listed function motor deduced. At same time, eight-node hexahedral calculate universal functions, inductance, flux linkage, induced electromotive force simulated two-dimensional three-dimensional...
Using chitosan and polyvinyl alcohol (PVA) as substrates, active packaging composite (VPC) films based on vanillin-crosslinked PVA/chitosan with different concentrations of added vanillin were prepared characterized. The results show that the VPC exhibited higher tightness hydrophobicity, lower water content vapor permeability, well better UV resistance. potential interactions between film groups analyzed by SEM, FTIR, XRD, showed formation Schiff base hydrogen bond affected properties...
Age-related macular degeneration (AMD) represents a major reason for blindness in the elderly population. Oxidative stress is predominant factor pathology of AMD. We previously evaluated effects phospholipid complex quercetin (Q-PC) on oxidative injury ARPE-19 cells, but underlying mechanisms are not fully understood. Herein, solid dispersion quercetin-PC (Q-SD) was prepared with solubility being 235.54 μg/mL water and 2.3×104 chloroform, which were significantly higher than that (QT) Q-PC....
Abstract Memory loss is the most common clinical sign in Alzheimer's disease (AD); thus, searching for peripheral biomarkers to predict cognitive decline promising early diagnosis of AD. As platelets share similarities neuron biology, it may serve as a matrix neurological disorders. Here, we conducted comprehensive and in‐depth platelet proteomic analysis using TMT‐LC‐MS/MS populations with mild impairment (MCI, MMSE = 18–23), severe impairments (AD, 2–17), age‐/sex‐matched normal cognition...
Temperature is an important factor affecting the growth, development and survival of marine organisms. A short episode high temperature has been proven to be a severe threat sustainable shellfish culture. Zhikong scallop (Chlamys farreri), with broad economic biological value in North China, frequently experienced heat stress summer recent years. To understand effects on shellfish, metabolism C. farreri was analyzed after exposure 27 °C for either 6 h or 30 d. After exposure, total 326 264...
Chronic pain is one of the most significant medical problems throughout world. Recent evidence has confirmed hippocampus as an active modulator chronicity, but underlying mechanisms remain unclear. Using in vivo electrophysiology, we identify a neural ensemble ventral hippocampal CA1 (vCA1) that shows inhibitory responses to noxious not innocuous stimuli. Following peripheral inflammation, this becomes responsive stimuli, representing hypersensitivity. Mimicking inhibition vCA1 neurons using...
Mitochondrial dysfunction, especially tricarboxylic acid (TCA) cycle arrest, is strongly associated with Alzheimer's disease (AD), however, its systemic alterations in the central and peripheral of AD patients are not well defined. Here, we performed an integrated analysis brain blood cells transcriptomics to reveal expression levels nine TCA enzymes involving 35 genes. The results showed that related genes were consistently down-regulated brain, whereas 11 increased 16 decreased system....
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons at the substantia nigra. Mitochondrial dysfunction involved in mechanism cell damage (PD). 6-Hydroxydopamine (6-OHDA) dopamine analog which specifically damages neurons. Baicalein has been previously reported to have potential treatment PD. The purpose present study was investigate action baicalein against 6-OHDA injury SH-SY5Y cells. results showed that significantly...
The current study was aimed at evaluating the therapeutic implication of apigenin and to elucidate underlying mechanism. tert-butyl hydroperoxide (t-BHP) 200 μM used induce oxidative stress-associated injury in ARPE-19 cells. Apigenin concentrations less than 800 did not cause cytotoxic effects on Cell viability assay showed that significantly promoted cell survival t-BHP-treated Additionally, 100 protected cells from t-BHP-induced apoptosis. Molecular examinations demonstrated 400...
Lack of pharmacological strategies in clinics restricts the patient prognosis with myocardial ischemia/reperfusion (I/R) injury. The aim this study was to evaluate cardioprotection combined salvianolic acid B (SalB) and ginsenoside Rg1 (Rg1) against I/R injury further investigate underlying mechanism. induced by coronary artery ligation for Wistar male rats hypoxia/reoxygenation on H9c2 cells. Firstly, best ratio between SalB Rg1was set as 2:5 based their effects heart function detected...
Oxidative stress is a critical factor in the pathology of age-related macular degeneration (AMD). Apigenin (AP) flavonoid with an outstanding antioxidant activity. We had previously observed that AP protected APRE-19 cells against oxidative injury vitro . However, has poor water and fat solubility, which determines its low oral bioavailability. In this study, we prepared solid dispersion apigenin (AP-SD). The solubility dissolution AP-SD was significantly better than original drug, so...
Abstract: Lignocellulose utilization has the unique feature of net-zero carbon emissions. Thus, lignocellulose as a renewable alternative to fossil-based resources is one most promising strategies achieve "carbon neutrality". Lignin been recognized abundant aromatic biopolymer on Earth; hence, it could be aromatics. The efficient dissolution lignin crucial for upgrading, which relies design innovative and robust solvents. Herein, we designed several biomass-derived acidic deep eutectic...
Abstract Background The systematic molecular associations between the peripheral blood cells and brain in Alzheimer's disease (AD) remains unclear, which hinders our understanding of AD pathological mechanisms exploration new diagnostic biomarkers. Methods Here, we performed an integrated analysis transcriptomics to establish biomarkers AD. By employing multiple statistical analyses plus machine learning, identified validated regulated central network patients with Results bioinformatics...
Abstract Aortic dissection (AD), a severe cardiovascular disease with the characteristics of high mortality, is lack specific clinical biomarkers. In order to facilitate diagnosis AD, we investigated plasma amino acid profile through metabolomics approach. Total 33 human subjects were enrolled in study: 11 coronary heart (CHD) patients without aortic lesion and acute AD chronic AD. Amino acids identified using liquid chromatography mass spectrometry (LC-MS/MS), further subjected multiple...