A5101419028- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Nuclear Receptors and Signaling
- Aortic aneurysm repair treatments
- Olfactory and Sensory Function Studies
- Metabolomics and Mass Spectrometry Studies
- Dementia and Cognitive Impairment Research
- Berberine and alkaloids research
- Urinary Bladder and Prostate Research
- Tryptophan and brain disorders
- Cholesterol and Lipid Metabolism
- Gastrointestinal motility and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Phytochemical Studies and Bioactivities
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Pelvic floor disorders treatments
- Cardiac Fibrosis and Remodeling
- Circular RNAs in diseases
Jiangnan University
2023-2024
Beijing University of Chinese Medicine
2022-2024
Jiangxi Mental Health Center
2023
Zhejiang Cancer Hospital
2016
Mitochondrial dysfunction, especially tricarboxylic acid (TCA) cycle arrest, is strongly associated with Alzheimer's disease (AD), however, its systemic alterations in the central and peripheral of AD patients are not well defined. Here, we performed an integrated analysis brain blood cells transcriptomics to reveal expression levels nine TCA enzymes involving 35 genes. The results showed that related genes were consistently down-regulated brain, whereas 11 increased 16 decreased system....
Abstract Background The systematic molecular associations between the peripheral blood cells and brain in Alzheimer's disease (AD) remains unclear, which hinders our understanding of AD pathological mechanisms exploration new diagnostic biomarkers. Methods Here, we performed an integrated analysis transcriptomics to establish biomarkers AD. By employing multiple statistical analyses plus machine learning, identified validated regulated central network patients with Results bioinformatics...
Abstract Background Olfactory dysfunction is known to be an early manifestation of Alzheimer's disease (AD). However, the underlying mechanism, particularly specific molecular events that occur during stages olfactory disorders, remains unclear. Methods In this study, we utilized transcriptomic sequencing, bioinformatics analysis, and biochemical detection investigate pathological characteristics bulb (OB) in 4‐month‐old male triple transgenic 3xTg‐AD mice (PS1M146V/APPSwe/TauP301L). Results...
Background MicroRNAs (miRNAs) are endogenous noncoding single-stranded small RNAs. Numerous studies have shown that miRNAs pivotal roles in the occurrence and development of myocardial fibrosis (MF). However, miRNA expression profile rats with MF after infarction (MI) is not well understood. The present study aimed to find potential for post MI. Methods SPF male Sprague-Dawley (SD) rat models acute (AMI) were established by ligating anterior descending branch left coronary artery, while...
Introduction: Alzheimer's Disease (AD) is the most common neurodegenerative disease, and timely effective diagnosis essential for prevention treatment of AD. Peripheral blood readily available, inexpensive, non-invasive, making it an ideal substrate screening diagnostic biomarkers. Method: The Notch signaling pathway closely related to AD, so genes may be candidate biomarkers Here, we have performed integrated analysis peripheral cells transcriptomics from two AD cohorts (GSE63060: Ctrl =...