A5065490195- Stress Responses and Cortisol
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Long-Term Effects of COVID-19
- Retinal Development and Disorders
- Anesthesia and Neurotoxicity Research
- Glioma Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Nerve injury and regeneration
- Memory and Neural Mechanisms
Peking University
2017-2024
National Health and Family Planning Commission
2020-2024
Pain chronicity involves unpleasant experience in both somatosensory and affective aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However, whether specific PFC neuronal ensembles underlie pain remains elusive. Here we identify a nociceptive ensemble dorsomedial (dmPFC), which shows prominent reactivity to stimuli. We observed that this distinct molecular characteristics is densely connected pain-related regions including basolateral amygdala (BLA) lateral...
Chronic pain is one of the most significant medical problems throughout world. Recent evidence has confirmed hippocampus as an active modulator chronicity, but underlying mechanisms remain unclear. Using in vivo electrophysiology, we identify a neural ensemble ventral hippocampal CA1 (vCA1) that shows inhibitory responses to noxious not innocuous stimuli. Following peripheral inflammation, this becomes responsive stimuli, representing hypersensitivity. Mimicking inhibition vCA1 neurons using...
A large proportion of patients with chronic pain experience co-morbid anxiety. The medial prefrontal cortex (mPFC) is proposed to underlie this comorbidity, but the molecular and neuronal mechanisms are not fully understood. Here, we reported that impaired macroautophagy in prelimbic cortical (PrL) subregion mPFC paralleled occurrence anxiety-like behaviors rats spared nerve injury (SNI). Intriguingly, such impairment was mainly observed a FOS/c-Fos+ subpopulation PrL. Chemogenetic...
A CRISPR-based technique achieves projection- and function-specific gene editing in the rat brain.
Over-generalized fear is a maladaptive response to harmless stimuli or situations characteristic of posttraumatic stress disorder (PTSD) and other anxiety disorders. The dorsal dentate gyrus (dDG) contains engram cells that play crucial role in accurate memory retrieval. However, the coordination mechanism neuronal subpopulations within dDG network during generalization not well understood. Here, with Tet-off system combined immunostaining two-photon calcium imaging, we report labeled...
Abstract Coronavirus disease 2019 (COVID‐19) has been suggested to increase the risk of memory decline and Alzheimer's (AD), main cause dementia in elderly. However, direct evidence about whether COVID‐19 induces AD‐like neuropathological changes brain, especially post recovery from acute infection, is still lacking. Here, using postmortem human brain samples, we found abnormal accumulation hyperphosphorylated tau protein hippocampus medial entorhinal cortex within 4–13 months clinically...
Chronic pain is a significant health problem worldwide. Recent evidence has suggested that dysfunctional states of the ventral hippocampus, including decreased neuronal excitability and connectivity with other brain regions, parallel chronicity persistent nociceptive hypersensitivity in humans rodents, respectively. But molecular mechanisms underlying hippocampal modulation remain poorly elucidated. In this study, we used ex vivo whole-cell patch-clamp recording, immunofluorescence staining...
Chronic pain is a significant health problem worldwide. Recent evidence has suggested that the ventral hippocampus dysfunctional in humans and rodents, with decreased neuronal excitability connectivity other brain regions, parallel chronicity, persistent nociceptive hypersensitivity. But molecular mechanisms underlying hippocampal modulation of remain poorly elucidated. In this study, we used ex vivo whole-cell patch-clamp recording, immunofluorescence staining, behavioral tests to examine...