A5067691317- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Receptor Mechanisms and Signaling
- bioluminescence and chemiluminescence research
- Neuropeptides and Animal Physiology
- Photoreceptor and optogenetics research
- Climate Change and Health Impacts
- Pharmacological Effects and Assays
- Air Quality and Health Impacts
- Molecular Sensors and Ion Detection
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Animal Disease Management and Epidemiology
- Nicotinic Acetylcholine Receptors Study
- Cancer, Stress, Anesthesia, and Immune Response
- Esophageal Cancer Research and Treatment
- Vector-Borne Animal Diseases
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Advanced Chemical Sensor Technologies
- Gut microbiota and health
- Air Quality Monitoring and Forecasting
- Gastric Cancer Management and Outcomes
Beijing Anzhen Hospital
2024-2025
Capital Medical University
2024-2025
Sichuan Agricultural University
2022-2025
China Agricultural University
2013-2025
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2025
Shandong University
2015-2024
Zhengzhou University
2024
China University of Geosciences
2024
Tianjin Medical University
2013-2023
Ministry of Education of the People's Republic of China
2022-2023
Nanotheranostics with integrated diagnostic and therapeutic functions show exciting potentials towards precision nanomedicine. However, targeted delivery of nanotheranostics is hindered by several biological barriers. Here, we report the development a dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for ultra-small, full active pharmaceutical ingredients (API) dual-modal imaging trimodal functions. pPhD NPs exhibit ideal size charge drug transportation. In tumour...
African swine fever is a highly contagious animal disease affecting the pig industry worldwide, which has brought enormous economic losses. Infection by causative agent, virus (ASFV), causes severe immunosuppression during viral infection, contributing to serious clinical manifestations.
Reactive oxygen species (ROS) often have significant roles in mediating redox modifications and other essential physiological processes, such as biological process regulation signal transduction. Considering that H2O2 is a substantial member of ROS, detection quantitation undertakes important but urgent responsibility. In this report, bioluminescent probe for detecting was well designed, synthesized, evaluated. This designed into three parts: H2O2-sensitive aryl boronic acid, aminoluciferin...
To investigate the genetic basis of pleuromutilin resistance in porcine methicillin-resistant Staphylococcus aureus (MRSA) and to map environment identified plasmid-borne gene.Seventy MRSA isolates, which exhibited high MICs tiamulin, valnemulin retapamulin, were investigated for genes mutations. They characterized by staphylococcal cassette chromosome mec (SCCmec) typing, spa typing multilocus sequence (MLST). Plasmid DNA was extracted from lsa(E)-positive strains transferred S. RN4220...
Abstract N6‐methyladenosine (m6A) RNA methylation, one of the common modifications, has been determined to execute crucial functions in tumorigenesis and cancer development. The m6A “writers” including methyltransferase like 3 (METTL3), METTL14, Wilms tumor 1‐associated protein (WTAP) contribute modification process initiation. However, coordination complex is not fully understood endometrioid epithelial ovarian (EEOC). In this study, mRNA levels METTL3, WTAP were detected 33 EEOC cases...
The efficacy of therapeutics for brain tumors is seriously hampered by multiple barriers to drug delivery, including severe destabilizing effects in the blood circulation, blood-brain barrier/blood-brain tumor barrier (BBB/BBTB), and limited uptake. Here, a sequential targeting crosslinking (STICK) nanodelivery strategy presented circumvent these important physiological improve delivery tumors. STICK nanoparticles (STICK-NPs) can sequentially target BBB/BBTB cells with surface maltobionic...
Abstract Photodynamic therapy (PDT) has emerged as an attractive alternative in cancer therapy, but its therapeutic effects are limited by the nonselective subcellular localization and poor intratumoral retention of small‐molecule photosensitizes. Here a fiber‐forming nanophotosensitizer (PQC NF) that is composed mitochondria targeting small molecules amphiphilicity reported. Harnessing specific targeting, light‐activated PQC NFs produce approximately 110‐fold higher amount reactive oxygen...
Evidence is still limited for the role of long-term PM2.5 exposure in cerebrovascular diseases among residents high pollution regions. The study aimed to investigate effects on stroke mortality, and further explore effect modification temperature variation PM2.5-mortality association northern China. Based a cohort data with an average follow-up 9.8 years 38,435 urban adults, high-resolution estimates derived from satellite-based model were assigned each participant. A Cox regression...
Small interfering RNA (siRNA) is utilized as a potent agent for cancer therapy through regulating the expression of genes associated with tumors. While widely application siRNAs in treatment severely limited by their insufficient biological stability and its poor ability to penetrate cell membranes. Targeted delivery systems hold great promise selectively deliver loaded drug tumor site reduce toxic side effect. However, elevated interstitial fluid pressure efficient cytoplasmic release are...
To compare the efficacy and safety of pembrolizumab combined with neoadjuvant chemotherapy (neoCT) versus chemoradiotherapy (neoCRT) followed by surgery for locally advanced resectable oesophageal squamous cell carcinoma (ESCC).This study is a multicentre, prospective, randomized-controlled, phase III clinical study. Eligible ESCC (staging: cT1N2M0 or cT2-3N0-2M0 (stage II/III, high-risk lesions in T2N0M0)) patients will be randomly assigned to either experimental group (pembrolizumab neoCT,...
Several literatures have examined the risk of chronic respiratory diseases in association with short-term ambient PM2.5 exposure China. However, little evidence has impacts on morbidity cohorts from high pollution countries. Our study aims to investigate associations. Based a retrospective cohort among adults northern China, Cox regression model time-varying and concentration-response (C-R) curve were performed access relationships between incidence long-term during mean follow-up time 9.8...
The African swine fever virus (ASFV) has caused a devastating pandemic in domestic and wild swine, causing economic losses to the global industry. Recombinant live attenuated vaccines are an attractive option for ASFV treatment. However, safe effective against still scarce, more high-quality experimental vaccine strains need be developed. In this study, we revealed that deletion of genes DP148R, DP71L, DP96R from highly virulent isolate CN/GS/2018 (ASFV-GS) substantially virulence swine....
To enhance the efficiency of firefly luciferase/luciferin bioluminescence imaging, a series N-cycloalkylaminoluciferins (cyaLucs) were developed by introducing lipophilic N-cycloalkylated substitutions. The experimental results demonstrate that these cyaLucs are effective substrates for native luciferase (Fluc) and can produce elevated bioluminescent signals in vitro, cellulo, vivo. It should be noted that, animal studies, N-cyclobutylaminoluciferin (cybLuc) at 10 μM (0.1 mL), which is 0.01%...
Bcl-2/adenovirus E1B 19-kDa interacting protein (BNIP3), a pro-apoptosis regulated by the methylation status of its promoter, has been implicated in inducing autophagy. However, roles BNIP3 and BNIP3-induced autophagy under hypoxia remain uncertain esophageal squamous cell carcinoma (ESCC). Two cancer lines, CAES17 KYSE140, were selected on basis expression to investigate features hypoxia. Hypoxia increased death BNIP3, whose promoter was lower methylation, time-dependent manner. knockdown...
Abstract Integration of the unique advantages fields drug discovery and delivery is invaluable for advancement development. Here we propose a self-delivering o ne-component n ew-chemical-entity anomedicine (ONN) strategy to improve cancer therapy through incorporation self-assembly principle into design. A lysosomotropic detergent (MSDH) an autophagy inhibitor (Lys05) are hybridised develop bisaminoquinoline derivatives that can intrinsically form nanoassemblies. The selected BAQ12 BAQ13...
Abstract The N 6 ‐methyladenosine (m A) modification is one of the most prevalent methylations in eukaryotic messenger RNA (mRNA), and it essential for development many important biological processes such as multiple types tumors. One enzymes catalyzing generation m A on mRNA Wilms' tumor 1‐associating protein (WTAP); however, potential role WTAP endometrial cancer (EC) still remains unknown. Here, we investigated expression level tissue paracancerous from an EC patient. Subsequently, was...
Targeted protein degradation (TPD) strategies open up new avenues for therapeutics and provide powerful tools biological inquiry. Herein, we present a brand-new approach, termed heat shock 90 (HSP90)-mediated targeting chimeras (HEMTACs), to induce intracellular by bridging target HSP90 drive the downregulation of proteins. We successfully showcase HEMTACs cyclin-dependent kinase 4 6 (CDK4/6) using flexible linker connect warhead CDK4/6 with ligand. Overall, our study delivers series...