A5100451003- Birth, Development, and Health
- Pancreatic function and diabetes
- Gestational Diabetes Research and Management
- Air Quality and Health Impacts
- Diabetes and associated disorders
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Vehicle emissions and performance
- Metabolism, Diabetes, and Cancer
- Air Quality Monitoring and Forecasting
- T-cell and B-cell Immunology
- Diabetes Treatment and Management
- CRISPR and Genetic Engineering
- Plant Molecular Biology Research
- Ubiquitin and proteasome pathways
- Lung Cancer Diagnosis and Treatment
- Catalytic Processes in Materials Science
- Advanced oxidation water treatment
- Cancer-related gene regulation
- Educational Assessment and Pedagogy
- Diabetes Management and Research
- Molecular Biology Techniques and Applications
Inner Mongolia University of Science and Technology
2025
Baotou Medical College
2025
Beijing Institute of Technology
2025
East China Normal University
2022-2024
Tianjin Medical University
2019-2024
Mongolian University of Science and Technology
2024
Shanxi Agricultural University
2024
Xi'an Jiaotong University
2023-2024
Dalian University of Technology
2024
Peking Union Medical College Hospital
2008-2023
Scope: Overnutrition in utero is a critical contributor to the susceptibility of diabetes by programming, although exact mechanism not clear. In this paper, we aimed study long-term effect maternal high-fat (HF) diet on offspring through epigenetic modifications. Procedures: Five-week-old female C57BL6/J mice were fed HF or control for 4 weeks before mating and throughout gestation lactation. At postnatal week 3, pups continued consume switched 5 weeks, resulting four groups differing their...
Emerging studies revealed that maternal protein restriction was associated with increased risk of type 2 diabetes mellitus in adulthood. However, the mechanisms its effects on offspring, especially during early life are poorly understood. Here, it is hypothesized impaired metabolic health offspring from low-protein diet (LPD) perturbed miRNAs expression as weaning age. We examined C57BL/6J mice male at dams fed LPD or normal chow (NCD) throughout pregnancy and lactation. Maternal feeding...
Several literatures have examined the risk of chronic respiratory diseases in association with short-term ambient PM2.5 exposure China. However, little evidence has impacts on morbidity cohorts from high pollution countries. Our study aims to investigate associations. Based a retrospective cohort among adults northern China, Cox regression model time-varying and concentration-response (C-R) curve were performed access relationships between incidence long-term during mean follow-up time 9.8...
Currently, pulmonary nodules detection work mostly focus on recognition and diagnosis of solid nodules. However, ground glass have higher probability malignancy, posing greater identification challenges thus value for detection. To achieve rapid accurate This article proposed an algorithm based RT-DETR model with the following enhancement: 1) optimize backbone network FCGE blocks to increase accuracy small-sized blurred edge nodules; 2) replace AIFI module HiLo-AIFI reduce redundant...
Objective This study explored how coach leadership behavior, achievement goal orientation, and basic psychological needs affect athlete engagement. Methods Based on self-determination theory, this examined the influence of behavior orientation engagement, as well mediating effect needs. The utilized established scales, including Leadership Behavior Scale for Coaches-15 (LSS-15), Achievement Goal Questionnaire Sport (AGQ-S), Athlete Engagement (AEQ) Basic Psychological Needs (BPNQ). Results A...
Mycobacterium tuberculosis encodes a proteasome that is highly similar to eukaryotic proteasomes and required cause lethal infections in animals. The only pathway known target proteins for proteasomal degradation bacteria pupylation, which functionally analogous ubiquitylation. However, evidence suggests the M. contributes pupylation-independent pathways as well. To identify new cofactors might contribute such pathways, we isolated bound overproduced found previously uncharacterized protein,...
The aim of this study was to determine the influence birth weight, a marker fetal growth, on development later impaired glucose metabolism throughout life span people living in China.We recorded detailed anthropometric data including height, and health status measured blood levels insulin concentrations after fasting at 120 min standard oral tolerance test from 2,019 eligible subjects born between 1921 1954 investigate risk developing type 2 diabetes regulation (IGR).The IGR groups were...
Little is known about the function of natural IgM autoantibodies, especially that anti-leukocyte autoantibodies (IgM-ALA). Natural IgM-ALA are present at birth and characteristically increase during inflammatory infective conditions. Our prior clinical observations those other investigators showing fewer rejections in renal cardiac allografts transplanted into recipients with high levels led us to investigate whether regulate response. In this article, we show IgM, physiologic doses, inhibit...
Cdc7-Dbf4 kinase or DDK (Dbf4-dependent kinase) is required to initiate DNA replication by phosphorylating and activating the replicative Mcm2-7 helicase. overexpressed in many tumor cells an emerging chemotherapeutic target since inhibition causes apoptosis of diverse cancer cell types but not normal cells. PHA-767491 XL413 are among a number potent inhibitors with low nanomolar IC50 values against purified kinase. Although highly selective for DDK, its activity has been extensively...
Rhodotorula mucilaginosa shows adaption to a broad range of Pb2+ stress. In this study, three key pathways, i.e., glycolysis (EMP), the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation (OXPHOS), were investigated under 0-2,500 mg · L-1 Pb stress, primarily based on biochemical analysis RNA sequencing. R. cells showed similar metabolic response low/medium (500/1000 L-1) High (2,500 stress exerted severe cytotoxicity mucilaginosa. The downregulation HK low-medium suggested...
Background Tuberculosis (TB) is a major global public health problem. New treatment methods on TB are urgently demanded. Methods Ninety-six female BALB/c mice were challenged with 2×10 4 colony-forming units (CFUs) of MTB H 37 Rv through tail vein injection, then was treated 10μg, 50μg, 100μg, and 200μg Mycobacterium tuberculosis (MTB) ag85a/b chimeric DNA vaccine delivered by intramuscular injection (IM) electroporation (EP), respectively. The immunotherapeutic effects evaluated...
Abstract Objective : Acetyl CoA carboxylase (ACC) is a key enzyme in energy balance. It controls the synthesis of malonyl‐CoA, an allosteric inhibitor carnitine palmitoyltransferase‐1 (CPT‐I). CPT‐I gatekeeper free fatty acid (FFA) oxidation. To test hypothesis that both enzymes play critical roles regulation FFA partitioning adipocytes, we compared mRNA expression and specific activity from fed, fasted, diabetic rats. Research Methods Procedures Direct effects nutritional state, insulin,...
Chronic heart failure affects myocardial energy metabolism and cardiac function. Puerarin has been reported to improve function through regulation of in mice with infarction. The aim the current study was determine whether puerarin can body weight reduce inflammation apoptosis rats chronic failure. Rats were divided into three groups: Puerarin, PBS sham group. Transverse aortic constriction performed induce an groups. Cardiac function, evaluated following a 4-week treatment results...
Abstract Air quality data prediction in urban area is of great significance to control air pollution and protect the public health. The monitoring station well studied existing researches. However, air-quality-monitor stations are insufficient most cities varies from one place another dramatically due complex factors. A novel model established this paper estimate predict Quality Index (AQI) areas without Nanjing. proposed predicts AQI a non-monitoring both temporal dimension spatial...
Glucokinase-maturity onset diabetes of the young (GCK-MODY) represents a rare genetic disorder due to mutation in glucokinase (GCK) gene. The low incidence vascular complications GCK-MODY makes it natural paradigm for interrogating molecular mechanisms promoting health under prolonged hyperglycemia. Clinical rate misdiagnosis has remained high, and reliable serum lipid biomarker that precedes screening can facilitate correct diagnosis treatment. Herein, we comprehensively quantitated 565...