A5012533395- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Dietary Effects on Health
- Pancreatic function and diabetes
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Adipokines, Inflammation, and Metabolic Diseases
- Neuropeptides and Animal Physiology
- Eating Disorders and Behaviors
- Neurotransmitter Receptor Influence on Behavior
- Animal testing and alternatives
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Metabolism, Diabetes, and Cancer
- Genetics, Aging, and Longevity in Model Organisms
- Lipid metabolism and biosynthesis
- Mindfulness and Compassion Interventions
- SARS-CoV-2 and COVID-19 Research
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- RNA and protein synthesis mechanisms
- Hypothalamic control of reproductive hormones
- Nuclear Receptors and Signaling
University of Amsterdam
2017-2024
Netherlands Institute for Neuroscience
2017-2024
Amsterdam Neuroscience
2019-2023
Amsterdam University Medical Centers
2019-2023
Royal Netherlands Academy of Arts and Sciences
2011-2021
Joslin Diabetes Center
2015-2020
Harvard University
2015-2019
University of California, Davis
2019
Amsterdam UMC Location University of Amsterdam
2017-2018
University of Cincinnati
2011-2015
Obesity is caused by an imbalance between energy intake and expenditure has become a major health-care problem in western society. The central melanocortin system plays crucial role the regulation of feeding expenditure, functional loss receptor 4 (MC4R) most common genetic cause human obesity. In this study, we present first Mc4r knockout model rat, resulting from N-ethyl-N-nitrosourea mutagenesis-induced point mutation. vitro observations revealed impaired membrane-binding subsequent...
In our ageing global population, the cognitive decline associated with dementia and neurodegenerative diseases represents a major healthcare problem. To date, there are no effective treatments for age-related impairment, thus preventative strategies urgently required. Physical exercise is gaining traction as non-pharmacological approach to promote brain health. Adult hippocampal neurogenesis (AHN), unique form of plasticity which necessary certain functions declines age enhanced in response...
The development of animal models with construct, face, and predictive validity to accurately model human depression has been a major challenge. One proposed rodent is the 5 d repeated forced swim stress (5d-RFSS) paradigm, which progressively increases floating during individual sessions. onset persistence this behavior anthropomorphically characterized as measure depression. This interpretation under debate because progressive increase in over time may reflect an adaptive learned behavioral...
Current epidemic obesity levels apply great medical and financial pressure to the strenuous economy of obesity-prone cultures, neuropeptides involved in body weight regulation are regarded as attractive targets for a possible treatment humans. The lateral hypothalamus nucleus accumbens shell (AcbSh) form hypothalamic-limbic neuropeptide feeding circuit mediated by Melanin-Concentrating Hormone (MCH). MCH promotes behavior via receptor-1 (MCH1R) AcbSh, although this relationship has not been...
Through analysis of mice with spatially and temporally restricted inactivation Lpin1, we characterized its cell autonomous function in both white (WAT) brown (BAT) adipocyte development maintenance. We observed that the lipin 1 adipocytes aP2Cre/+/LpfEx2-3/fEx2-3 resulted lipodystrophy presence multilocular lipid droplets. further showed time-specific loss mature aP2Cre-ERT2/+/LpfEx2-3/fEx2-3 led to their replacement by newly formed Lpin1-positive adipocytes, thus establishing a role for...
Abstract Diet-induced obesity (DIO) reduces the ability of centrally administered insulin to reduce feeding behavior and also transport from periphery central nervous system (CNS). The current study was designed determine whether reversal high-fat DIO restores anorexic efficacy this is accompanied by restoration compromised transport. Adult male Long-Evans rats were initially maintained on either a low-fat chow diet (LFD) or (HFD). After 22 weeks, half animals HFD changed LFD, whereas other...
Bariatric surgery is currently the most effective treatment for obesity. Vertical sleeve gastrectomy (VSG), a commonly applied bariatric procedure, involves surgically incising of volume stomach. In humans, partial loss melanocortin receptor-4 ( MC4R) activity common monogenic correlate obesity regardless lifestyle. At present it unclear whether genetic alteration MC4R signaling modulates beneficial effects VSG. Following VSG, we analyzed body weight, food intake, glucose sensitivity, and...
Objective Poor maternal and paternal environments increase the risk for obesity diabetes in offspring, whereas exercise mice can improve offspring metabolic health. We determined effects of combined on health parental pancreas phenotype, a major tissue regulating glucose homeostasis. Research design methods Breeders were high fat fed housed±running wheels before breeding (males) during gestation (females). Offspring groups were: both parents sedentary (Sed); only (Mat Ex); (Pat...
Uroguanylin is a gastrointestinal hormone primarily involved in fluid and electrolyte handling. It has recently been reported that prouroguanylin, secreted postprandially, converted to uroguanylin the brain activates receptor guanylate cyclase-C (GC-C) reduce food intake prevent obesity. We tested central nervous system administration of two GC-C agonists found no significant reduction intake. also carefully phenotyped mice lacking them have normal body weight, adiposity, glucose tolerance....
Overconsumption of a high-fat diet promotes weight gain that can result in obesity and associated comorbidities, including Type 2 diabetes mellitus. Consumption also alters gut-brain communication. Glucagon-like peptide 1 (GLP-1) is an important gastrointestinal signal modulates both short- long-term energy balance integral maintenance glucose homeostasis. In the current study, we investigated whether diets (40% or 81% kcal from fat) modulated ability GLP-1 receptor (GLP-1r) agonists...
Postnatal development and puberty are times of strong physical maturation require large quantities energy. The hypothalamic neuropeptide melanin-concentrating hormone (MCH) regulates nutrient intake energy homeostasis, but the underlying mechanisms not completely understood. Here we use a novel rat knockout model in which MCH precursor Pmch has been inactivated to study effects loss on regulation more detail. Pmch(-/-) rats lean, hypophagic, osteoporotic, although endocrine parameters were...
The Lpin1 gene encodes the phosphatidate phosphatase (PAP1) enzyme Lipin 1, which plays a critical role in lipid metabolism. In this study we describe identification and characterization of rat model with mutated (Lpin11Hubr), generated by N-ethyl-N-nitrosourea mutagenesis. Lpin11Hubr rats are characterized hindlimb paralysis mild lipodystrophy that detectable from second postnatal week. Sequencing identified point mutation 5′-end splice site intron 18 resulting mis-splicing, reading...