A5101579664- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Maternal Mental Health During Pregnancy and Postpartum
- Sexual function and dysfunction studies
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Hormonal and reproductive studies
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Child and Adolescent Psychosocial and Emotional Development
- Birth, Development, and Health
- Hypothalamic control of reproductive hormones
- Memory and Neural Mechanisms
- Pharmaceutical studies and practices
- Sexuality, Behavior, and Technology
- Neonatal Respiratory Health Research
- Alcohol Consumption and Health Effects
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Animal testing and alternatives
- Gut microbiota and health
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Urinary Bladder and Prostate Research
University of Groningen
2016-2025
Utrecht University
2007-2024
Yale University
2002-2024
Amsterdam University Medical Centers
2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2023
Pharmo Institute
2021
Technical University of Denmark
2021
Severtsov Institute of Ecology and Evolution
2021
Dialyse Centrum Groningen
2015-2020
Uppsala University
2013-2019
The transcription factor cAMP response element (CRE)-binding protein (CREB) has been shown to regulate neural plasticity. Drugs of abuse activate CREB in the nucleus accumbens, an important part brain's reward pathways, and local manipulations activity have affect cocaine reward, suggesting active role adaptive processes that follow exposure drugs abuse. Using CRE-LacZ reporter mice, we show not only rewarding stimuli such as morphine, but also aversive stress, CRE-mediated accumbens shell....
Previous work has shown that tree turnover, biomass and large liana densities have increased in mature tropical forest plots the late twentieth century. These results point to a concerted shift ecological processes may already be having significant impacts on terrestrial carbon stocks, fluxes biodiversity. However, findings proved controversial, partly because rather limited number of permanent been monitored for short periods. The aim this paper is characterize regional–scale patterns ‘tree...
The DSM-IV diagnostic criteria for premature ejaculation remain to be investigated by a clinical study. A prospective study was therefore conducted investigate the definition and provide an empirical operationalization of ejaculation. In this 140 men suffering from lifelong were interviewed separately their partners. Various means assessing intravaginal latency time (IELT) compared: assessment spontaneous answer, questionnaire, imagining foreplay intercourse estimating without clock or with...
The rat is one of the most important model organisms for biomedical and pharmacological research. However, generation novel models studying specific aspects human diseases largely depends on selection traits using existing strains, thereby solely depending naturally occurring variation. This study aims to provide tools manipulate genome in a more directed way.We developed robust, automated, scaleable reverse genetic methodology based ENU (N-ethyl-N-nitrosourea)-driven target-selected...
While individual differences in vulnerability to psychostimulants have been largely attributed dopaminergic neurotransmission, the role of serotonin is not fully understood. To study rewarding and motivational properties cocaine transporter knockout (SERT−/−) rat involvement compensatory changes 5-HT1A receptor function are objectives study. The SERT−/− was tested for cocaine-induced locomotor activity, conditioned place preference, intravenous self-administration. In addition, expression...
It has been estimated that 20% of pregnant women suffer from depression and it is well documented maternal can have long-lasting effects on the child. Currently, common treatment for selective serotonin reuptake inhibitor medications (SSRIs) which are used by 2-3% in Nordic countries up to 10% United States. Antidepressants cross placenta transferred fetus, thus, question arises as whether children taking antidepressants at risk altered neurodevelopmental outcomes and, if so, risks due SSRI...
The selective serotonin reuptake inhibitor (SSRI) Prozac® (fluoxetine) is the only registered antidepressant to treat depression in children and adolescents. Yet, while safety of SSRIs has been well established adults, exerts neurotrophic actions developing brain thereby may have harmful effects Here we treated adolescent adult rats chronically with fluoxetine (12 mg/kg) at postnatal day (PND) 25 46 from PND 67 88, respectively, tested animals 7-14 days after last injection when...
The neurotransmitter serotonin (5-HT) plays a vital regulatory role in both the brain and gut. 5-HT is crucial for regulating mood as well gastrointestinal motility secretion peripherally. Alterations transmission have been linked to pathological symptoms intestinal psychiatric disorders selective transporter (5-HTT) inhibitors, affecting system by blocking successfully used treat CNS- disorders. Humans that carry short allele of 5-HTT-linked polymorphic region (5-HTTLPR) are more vulnerable...
Antidepressant medication is often associated with sexual side effects. A double-blind, placebo-controlled study in men lifelong rapid ejaculation was performed to assess the effects of two selective serotonin (5-HT) reuptake inhibitors—paroxetine and sertraline—and 5-HT 2 antagonist 5-HT/noradrenaline inhibitor nefazodone on latency ejaculate. Forty-eight an intravaginal time (IELT) a maximum 1 minute were randomly assigned receive paroxetine (20 mg/day), sertraline (50 (400 or placebo for...
Selective serotonin reuptake inhibitors (SSRIs) are known to induce delayed orgasm and ejaculation. However, different SSRIs may differentially delay A double-blind, fixed-dose study in healthy men with lifelong rapid ejaculation was performed evaluate potential differences between clinically relevant doses of two selective inhibitors, paroxetine citalopram, their effects on Thirty an intravaginal latency time (IELT) less than 1 minute were randomly assigned receive (20 mg/day) citalopram...