A5087559454- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Epilepsy research and treatment
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Mast cells and histamine
- Cannabis and Cannabinoid Research
- Tryptophan and brain disorders
- Pharmaceutical industry and healthcare
- Botulinum Toxin and Related Neurological Disorders
- Nicotinic Acetylcholine Receptors Study
- Veterinary Pharmacology and Anesthesia
- Advanced MRI Techniques and Applications
- Neuroendocrine regulation and behavior
- Cardiac electrophysiology and arrhythmias
- Electroconvulsive Therapy Studies
- Attention Deficit Hyperactivity Disorder
- Ion channel regulation and function
- Olfactory and Sensory Function Studies
- Intellectual Property and Patents
Temple University
2024-2025
Wolters Kluwer (Netherlands)
2006-2016
Duquesne University
2016
Mylan (United States)
2016
University of Groningen
2002-2012
Grünenthal Group (Germany)
2008
Microdialysis was used to assess the involvement of postsynaptic 5‐hydroxytryptamine 1A (5‐HT ) receptors in regulation extracellular 5‐HT amygdala. Local infusion receptor agonist flesinoxan (0.3, 1, 3 µ m for 30 min into amygdala maximally decreased 50% basal level. Systemic administration citalopram (10 µmol/kg) increased 175% 1 antagonist WAY 100.635 augmented effect more than 500% responsiveness after chronic treatment determined two ways. First, by local amygdala, which showed a...
In microdialysis studies, neither exocytotic release of gamma-aminobutyric acid (GABA), nor the presence GABA type B (GABA(B)) autoreceptors, have been clearly established. It was investigated whether chromatographic separation may contributed to discrepancies in literature. After extending profile HPLC chromatogram a retention time 60 min, it observed that various unknown compounds biological origin co-eluted near peak. The appeared be extremely sensitive pH; even at around min there only...
Administration of bupropion [(±)-2-(<i>tert</i>-butylamino)-1-(3-chlorophenyl)propan-1-one] and its preformed active metabolite, hydroxybupropion [(±)-1-(3-chlorophenyl)-2-[(1-hydroxy-2-methyl-2-propanyl)amino]-1-propanone], to rats with measurement unbound concentrations by quantitative microdialysis sampling plasma brain extracellular fluid was used develop a compartmental pharmacokinetics model describe the blood–brain barrier transport both substances. The population revealed rapid...
A microdialysis method was developed to sample norepinephrine and acetylcholine from the heart of freely moving rats. flexible dialysis fiber (length 14 mm), with a copper wire inserted inside, implanted into heart. Extracellular detectable for at least 72 h after implantation. Basal output levels 24 surgery were 140 pg/ml when corrected in vitro recovery. Evidence provided that major part dialysates is derived local neurotransmission. Acetylcholine only cardiac an esterase inhibitor...