A5100641437- Pancreatic function and diabetes
- Lipoproteins and Cardiovascular Health
- Metabolism, Diabetes, and Cancer
- Pharmaceutical Economics and Policy
- MicroRNA in disease regulation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes, Cardiovascular Risks, and Lipoproteins
- X-ray Diffraction in Crystallography
- Reproductive Biology and Fertility
- Chromium effects and bioremediation
- Orthopedic Surgery and Rehabilitation
- Birth, Development, and Health
- Crystallization and Solubility Studies
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Elbow and Forearm Trauma Treatment
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Cancer survivorship and care
- Renal function and acid-base balance
- Ocular Surface and Contact Lens
- Biosimilars and Bioanalytical Methods
- Sperm and Testicular Function
- Childhood Cancer Survivors' Quality of Life
Beijing Jishuitan Hospital
2013-2025
Capital Medical University
2023-2025
Peking University
2013-2025
Qinghai University
2021-2025
Inner Mongolia Agricultural University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
Institute of Hematology & Blood Diseases Hospital
2023-2024
Southwest University of Science and Technology
2024
University of Alabama at Birmingham
2018-2024
Zhongyuan University of Technology
2024
An increased risk of cardiovascular and metabolic diseases (CVMDs) among patients with cancer suggests a potential link between CVMD cancer. The impact on the survival time esophageal gastric remains unknown. We aimed to determine incidence its longterm outcomes in patients.A total 2074 were enrolled from January 1, 2007 December 31, 2017 two hospitals, including 1205 cases 869 cancer, who followed up for median 79.8 79.3 months, respectively. Survival was analyzed using Kaplan-Meier method...
Maternal dietary modifications determine the susceptibility to metabolic diseases in adult life. However, whether maternal high-fat feeding can modulate glucose and lipid metabolism early life of offspring is less understood. Furthermore, we explored underlying mechanisms that influence phenotype. Using C57BL/6J mice, examined effects on at weaning from dams fed with a diet or normal chow throughout pregnancy lactation. Gene array experiments quantitative real-time PCR were performed liver...
MicroRNAs (miRNAs) are non-coding RNA molecules involved in the post-transcriptional regulation of a large number genes, including those glucose metabolism. Acarbose is an α-glucosidase inhibitor that improves glycemic control by decreasing intestinal absorption glucose, thereby elevation postprandial blood glucose. However, acarbose poorly absorbed into stream from gut. Therefore, exact mechanisms which affects metabolism unclear. This study investigated effect on diabetic rats and tested...
ABSTRACT Background Previous studies on Activities of Daily Living (ADL) suggest that the wrist demonstrates different ranges motion and frequencies in various directions. However, specific directional characteristics activities remain unexplored. This study aims to investigate motions during ADL with optical capture technology. Method is a basic science study. Twenty‐six right‐handed subjects executed 22 ADLs, angular positions tracked via retroreflective markers dominant limb. The...
Introduction The molecular mechanisms underlying intramuscular fat (IMF) deposition are crucial for enhancing lamb meat quality. This process is regulated by a network of transcription factors. Exploring the role non-coding RNAs, particularly lncRNAs and miRNAs, in IMF can clarify its complex genetics offer resources breeding Inner Mongolian local breeds. Methods We evaluated carcass quality parameters using 60 six-month-old Ujumqin sheep with similar body weights. To investigate RNA’s...
Berberine is known to improve glucose and lipid metabolism disorders, but it poorly absorbed into the blood stream from gut. Therefore, exact underlying mechanism for berberine still unknown. In this study, we investigated effect of on in diabetic rats tested hypothesis that acts directly terminal ileums.Rats were divided a control group, group (DM), low dose (BerL) high (BerH). Ileum samples analyzed using Roche NimbleGen mRNA array, qPCR immunohistochemistry.We found 8 weeks treatment with...
Abstract Chemotherapeutic drug of paclitaxel (PTX) has been shown to cause reproductive toxicity thus affecting male fertility, but its underlying molecular basis is unclear. Melatonin (MLT) can mitigate the damage caused by certain chemotherapy drugs. In this study, we aimed identify impact PTX on main biological processes and protective effect MLT PTX. Mice exposed mainly impaired spermatogenesis, such as decreased sperm counts, reduced motility increased abnormal sperm. Decreased...
An adverse intrauterine environment, induced by a chromium-restricted diet, is potential cause of metabolic disease in adult life. Up to now, the relative mechanism has not been clear. C57BL female mice were time-mated and fed either control diet (CD), or (CR) throughout pregnancy lactation period. After weaning, some offspring continued diagram (CD-CD CR-CR), while other transferred another (CD-CR CR-CD). At 32 weeks age, glucose metabolism parameters measured, liver from CR-CD group CD-CD...
Maternal undernutrition is linked with an elevated risk of diabetes mellitus in offspring regardless the postnatal dietary status. This also found maternal micro-nutrition deficiency, especial chromium which a key glucose regulator. We investigated whether restriction contributes to development by affecting DNA methylation status liver tissue. After being mated control males, female weanling 8-week-old C57BL mice were fed diet (CON, 1.19 mg chromium/kg diet) or low (LC, 0.14 during pregnancy...
In China, TianMai Xiaoke tablet (TM) is used to treat type 2 diabetes. However, the exact mechanism of TM not clear. This study investigate effect on glucose metabolism in diabetic rats and identify whether takes a direct action through microRNAs islet. Rats were divided into control group, low dose group (TML), high (TMH). Pancreas samples analyzed using microRNA array Q-PCR. Eight-week treatment with significantly decreased fasting blood glucose. The was reduced TM-treated groups before...
We evaluated the effect of chewing on blood GLP-1 concentration by having volunteers to chew sugarless gum. Our intention was explore neural mechanisms regulating secretion glucagon-like peptide-1(GLP-1). After fasting for 12 h, healthy male, non-obese (18 < BMI 30), were asked gum at a frequency 80 times every 2 min total 30 min. Blood samples collected before start and 5, 10, 15, 20, 25, after chewing. Satiety hunger scale from 0 100 each time point. Compared with control group, test...
To investigate the clinical and genetic characteristics of Chinese patients with a phenotype consistent maturity-onset diabetes young type 2 explore pathogenic mechanism their hyperglycemia.We studied 12 probands extended families referred to our center for screening mutations in glucokinase gene (GCK). Clinical data were collected analysis was carried out. The recombinant wild-type mutant generated Escherichia coli. kinetic parameters thermal stability enzymes determined vitro.In families,...
Glucokinase-maturity onset diabetes of the young (GCK-MODY) represents a rare genetic disorder due to mutation in glucokinase (GCK) gene. The low incidence vascular complications GCK-MODY makes it natural paradigm for interrogating molecular mechanisms promoting health under prolonged hyperglycemia. Clinical rate misdiagnosis has remained high, and reliable serum lipid biomarker that precedes screening can facilitate correct diagnosis treatment. Herein, we comprehensively quantitated 565...
Abstract Cyclophosphamide (CP) is a clinical anticancer drug that can cause male reproductive abnormalities, but the underlying mechanisms for this remain unknown. The present study aimed to explore potential toxicity induced by CP in spermatogenesis events of germ cell proliferation, meiosis, and blood‐testis barrier integrity at molecular level. CP‐treated mice showed significantly reduced serum testosterone levels, sperm motility concentration. results immunohistochemistry Western blot...
The 2018 American Heart Association/American College of Cardiology (AHA/ACC) cholesterol guideline recommends a maximally-tolerated statin with add-on lipid-lowering therapy, ezetimibe and/or proprotein convertase subtilisin/kexin type 9 (PCSK9) for adults very-high atherosclerotic cardiovascular disease (ASCVD) risk to achieve low-density lipoprotein (LDL-C) <70 mg/dL. We estimated the percentage US ASCVD recommended, by AHA/ACC guideline, and receiving therapy.Cross-sectional study...
One-dimensional core–shell hollow carbon nanofibers are prepared by a coaxial electrospinning method, which exhibits multi-surface properties that enhance electrolyte infiltration and facilitate ion/electron transport in sodium-ion batteries.