A5101564701- Sperm and Testicular Function
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Reproductive Biology and Fertility
- Circadian rhythm and melatonin
- Viral Infections and Immunology Research
- Virtual Reality Applications and Impacts
- Effects and risks of endocrine disrupting chemicals
- CAR-T cell therapy research
- Stroke Rehabilitation and Recovery
- Meta-analysis and systematic reviews
- Toxic Organic Pollutants Impact
- Global Public Health Policies and Epidemiology
- Microbial infections and disease research
- Embedded Systems Design Techniques
- Food Security and Health in Diverse Populations
- Traumatic Brain Injury Research
- Mesenchymal stem cell research
- VLSI and FPGA Design Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Public Health and Nutrition
- Tissue Engineering and Regenerative Medicine
University of Arizona
2024-2025
OriginWater (China)
2024
Yuhuangding Hospital
2022-2023
Qingdao University
2022-2023
Guizhou University
2023
Weifang Medical University
2023
Army Medical University
2018
Japan International Cooperation Agency
2016
Henan Agricultural University
2007-2012
Zero-event counts are common in clinical studies, particularly when assessing rare adverse events. These occurrences can result from low event rates, short follow-up periods, and small sample sizes. When both intervention control groups report zero events a trial, the study is referred to as double-zero-event study, which presents methodological challenges for evidence synthesis. There has been ongoing debate about whether these studies should be excluded synthesis, traditional two-stage...
Abstract Chemotherapeutic drug of paclitaxel (PTX) has been shown to cause reproductive toxicity thus affecting male fertility, but its underlying molecular basis is unclear. Melatonin (MLT) can mitigate the damage caused by certain chemotherapy drugs. In this study, we aimed identify impact PTX on main biological processes and protective effect MLT PTX. Mice exposed mainly impaired spermatogenesis, such as decreased sperm counts, reduced motility increased abnormal sperm. Decreased...
Doxorubicin (DOX) is an effective chemotherapy drug, but its clinical use has adverse effects on male reproduction. However, there are few studies about the specific biological processes related to reproduction or strategies for improving fertility protection. In this paper, we examined of DOX spermatogenesis and sperm function, tested possible protective role melatonin (MLT) against DOX's reproductive toxicity. DOX-treated mice showed signs significantly impaired spermatogenesis, including...
Abstract Chemotherapeutic drugs can cause reproductive damage by affecting sperm quality and other aspects of male fertility. Stem cells are thought to alleviate the caused chemotherapy play roles in protection treatment. This study aimed explore effects human umbilical cord mesenchymal stem (hUC-MSCs) on alleviating paclitaxel (PTX)-induced spermatogenesis fertility defects. An vivo PTX-induced mice model was constructed evaluate toxicity protective hUC-MSCs improvement. A 14 day PTX...
6518 Background: Chimeric antigen receptor (CAR) T-cell therapy has shown promising efficacy in B-cell malignancies (Majzner RG, et al. Nat Med. 2019 Sep;25(9):1341-1355). However, its feasibility acute myeloid leukemia (AML) is not fully established. CD33 CAR relapsed or refractory (r/r) AML have reported limited no significant anti-leukemic effects (Tambaro FP, Leukemia. 2021 Nov;35(11):3282-3286; Wang QS, Mol Ther. 2015 Jan;23(1):184-91). CD123 weak proliferation and low CR rates (Wermke...
Bisphenol A (BPA) exposure is known to cause damage male fertility. Conversely, melatonin (MLT) has been shown offer protection against reproductive by acting as an antioxidant. Exploration into the molecular mechanisms behind how MLT alleviates BPA-induced fertility remains unclear. In this study, adult mice were divided four groups of control, BPA (intragastrically, 50 mg/kg/day), treatment (intraperitoneal injection, 10 mg/kg/day) and combined BPA+MLT group for comparative analysis after...
Melatonin is a powerful antioxidant regulating various biological functions, including alleviating male reproductive damage under pathological conditions. Here, we aim to analyse the effect of melatonin on normal reproduction in mice.Male mice received an intraperitoneal injection (10mg/kg body weight) for 35 consecutive days. The testis and epididymis morphology, epididymal sperm parameters were examined. PCNA, HSPA2, SYCP3, ZO-1 CYP11A1 expressions or detected by immunohistochemistry...
Smoking remains a main cause of preventable death worldwide. The World Health Organization strategizes the implementation tobacco control through primary care services. A community-based (COPC) service fully considering social, environmental and life style influence on health, combines individual medical population based intervention. COPC guided smoking cessation intervention program is introduced with safety, convenience cost-effectiveness, it an important approach to promote health among...
Combining virtual reality (VR) with rehabilitation robots has the potential to enhance training and neural functional recovery. However, there is limited research on designing VR scenes evaluating impact of such systems participants' cognitive experiential aspects when using robots. This study aimed examine effects different gaming modes (first-person perspective third-person perspective) robot involvement motivation, experience, task load, engagement. Thirty-two participants underwent gait...