A5026582749- Meat and Animal Product Quality
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Advanced Chemical Sensor Technologies
- Fermentation and Sensory Analysis
- Trace Elements in Health
- Exercise and Physiological Responses
- Cardiac electrophysiology and arrhythmias
- Ion Channels and Receptors
- Bee Products Chemical Analysis
- Identification and Quantification in Food
- Consumer Behavior in Brand Consumption and Identification
- Insect Utilization and Effects
- Gut microbiota and health
- Nanoparticle-Based Drug Delivery
- Iron Metabolism and Disorders
- Collagen: Extraction and Characterization
- Probiotics and Fermented Foods
- Neuroscience and Neuropharmacology Research
- RNA Interference and Gene Delivery
- Nuclear Structure and Function
- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Dietary Effects on Health
- biodegradable polymer synthesis and properties
Baylor College of Medicine
2024
Chinese Academy of Agricultural Sciences
2021-2022
Ministry of Agriculture and Rural Affairs
2021-2022
Institute of Food Science and Technology
2021-2022
Hebei Medical University
2016-2022
China Institute of Sport Science
2022
Institute of Agro-Products Processing Science and Technology
2021
Hebei Agricultural University
2021
Virginia Commonwealth University
2019
This study was aimed to compare the physicochemical properties and bacterial community structure of tray-packaged fresh lamb meat under different storage temperatures, such as 4°C (chilling), −1.5°C (supercooling), −4°C (superchilling) −9°C (sub-freezing). The total viable counts (TVC), volatile base nitrogen (TVB-N), diversity metabolic pathways were investigated. results indicated that shelf life superchilling sub-freezing over 70 d, which significantly longer than chilling supercooling...
Small interfering RNA (siRNA) is utilized as a potent agent for cancer therapy through regulating the expression of genes associated with tumors. While widely application siRNAs in treatment severely limited by their insufficient biological stability and its poor ability to penetrate cell membranes. Targeted delivery systems hold great promise selectively deliver loaded drug tumor site reduce toxic side effect. However, elevated interstitial fluid pressure efficient cytoplasmic release are...
Significance M-type (Kv7, KCNQ) potassium channels are powerful regulators of neuronal and muscular excitability validated drug targets for the treatment disorders. The plasma membrane phosphoinositide phosphatidylinositol 4,5-bisphosphate (PIP 2 ) is required to maintain M channel activity. We report that intracellular free zinc directly reversibly augments activity recombinant native by reducing or virtually abolishing requirement PIP , thereby permitting a -gated ion operate independently...
The freshness and microbial community composition of lamb carcasses were evaluated under three chilling rates treatments: conventional (chilling rate was 1.76 °C/h), very fast chilling-I (VFC-I, 12.52 chilling-II (VFC-II, 14.52 °C/h). results showed that the indicator including total viable counts (TVC), volatile basic nitrogen (TVB-N), thiobarbituric acid reactive substance (TBARS) values VFC-II treatment lower than VFC-I treatments, bacterial species richness treatments increased with...
Key points Rat somatosensory neurons express a junctional protein, junctophilin‐4 (JPH4) JPH4 is necessary for the formation of store operated Ca 2+ entry (SOCE) complex at junctions between plasma membrane and endoplasmic reticulum in these neurons. Knockdown impairs refill signalling sensory In vivo knockdown dorsal root ganglion (DRG) significantly attenuated experimentally induced inflammatory pain rats. Junctional nanodomain maintained by an important contributor to mechanisms. Abstract...
The aim of this study was to investigate the effect chilling rate (1.44, 22.2, and 32.4 °C/h) on evolution volatile non-volatile compounds in raw lamb meat during refrigeration (1, 24, 72, 120 h). Through orthogonal projection latent structure-discriminant analysis, calculation odor activity values (OAV > 1) taste (TAV 1-octen-3-ol, (E, E)-2,4-decadienal, nonanal, hexanal, nona-3,5-dien-2-one, 2,3-octanedione, hexanoic acid, 1-nonen-4-ol, aspartate (Asp), Glutamic Acid (Glu), 5'-GMP, 5'-IMP,...
T-type Ca2+ channels are important regulators of peripheral sensory neuron excitability. Accordingly, currents often increased in various pathological pain conditions, such as inflammation or nerve injury. Here we investigated effects on functional expression small-diameter cultured dorsal root ganglion (DRG) neurons. We found that overnight treatment DRG cultures with a cocktail inflammatory mediators bradykinin (BK), adenosine triphosphate (ATP), norepinephrine (NE) and prostaglandin E2...
To investigate the effect of postmortem phases on lamb meat quality, physicochemical microstructure and water mobility oyster cut, short loin, knuckle silverside muscles from Small-Tail Han sheep were evaluated in pre-rigor, rigor mortis post-rigor phases. Pre-rigor had higher pH holding capacity (WHC), whereas lower CIE L*, b*, hue angle values than (p<0.05). The Warner-Bratzler shear force (WBSF) loin their pre-rigor counterparts, WBSF value its counterpart Muscle fibers shrank laterally...
Deboning methods are vital during fresh meat processing, influencing the evolution of spoilage. In this study, we examined effects deboning (including hot boning (HB), conventional chilling and (CCB) very fast (VFCB)) on freshness bacterial changes lamb cuts stored at 4 °C. The was evaluated by total volatile basic nitrogen (TVB-N), thiobarbituric acid reactive substances (TBARS), viable count mesophilic (TVCm) psychrophilic (TVCp), community determined 16S rRNA high-throughput sequencing....
T-type (Cav3) Ca2+ channels are important regulators of excitability and rhythmic activity excitable cells. Among other voltage-gated channels, Cav3 uniquely sensitive to oxidation zinc. Using recombinant protein expression in HEK293 cells, patch clamp electrophysiology, site-directed mutagenesis, homology modeling, we report here that modulation Cav3.2 by redox agents zinc is mediated a unique extracellular module containing high-affinity metal-binding site formed the IS1-IS2 IS3-IS4 loops...
Summary The objective of this study was to investigate the effect chilling rate on heat shock proteins (HSP) abundance, myofibrillar degradation and caspase‐3 activity lamb muscle in postmortem. Eighteen longissimus dorsi (LD) muscles from were treated under three different rates—very fast I (VFC‐I, 22.2 °C h −1 ), very II (VFC‐II, 32.4 ) control (1.44 )—and stored at °C, 4 for 120 postmortem, respectively. results showed that myofibril fragmentation index (MFI), abundance αβ‐crystallin...
Abstract Junctions of endoplasmic reticulum and plasma membrane (ER-PM junctions) serve as signaling hubs in prokaryotic cells. ER-PM junctions are present peripheral sensory neurons necessary for pro-inflammatory G protein coupled receptor signalling inflammatory pain generation. Yet, the principles assembly maintenance, well their role only beginning to emerge. Here we discovered that a member junctophilin family proteins, JPH4, is abundantly expressed rat dorsal root ganglion (DRG)...
The soaring prevalence of obesity and its complications presents a significant health care burden, there is currently lack effective sustainable treatment methods. Time-restricted eating (TRE) specific intermittent fasting (IF) protocol involving consistent periods within 24-hour cycle. can restore robust circadian rhythms improve metabolic health, providing an emerging dietary strategy for the prevention related diseases. Previous TRE trials laid groundwork, indicate need further clinical...
Microorganisms proliferate, consume nutrients, and produce many undesired metabolites, which are the main reason for spoilage of fresh meat. Screening markers is great significance characterizing freshness At present, there few studies on volatile lamb their relationship with bacteria. In this study, evolution was evaluated by multiple indicators. The changes bacteria organic compounds (VOCs) aerobic-packaged (AP) vacuum-packaged (VP) were measured 16S next-generation sequencing (NGS)...