A5023601668- Genetically Modified Organisms Research
- Mycotoxins in Agriculture and Food
- Gut microbiota and health
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Animal Genetics and Reproduction
- Insect Resistance and Genetics
- Advanced Nanomaterials in Catalysis
- Transgenic Plants and Applications
- Diet and metabolism studies
- RNA Interference and Gene Delivery
- Electrochemical sensors and biosensors
- Molecular Biology Techniques and Applications
- Dietary Effects on Health
- Selenium in Biological Systems
- Liver Disease Diagnosis and Treatment
- Plant Disease Resistance and Genetics
- Carcinogens and Genotoxicity Assessment
- Biosensors and Analytical Detection
- Nanocluster Synthesis and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related molecular mechanisms research
- Microbial Inactivation Methods
China Agricultural University
2016-2025
Ministry of Agriculture and Rural Affairs
2020-2025
Guangxi Academy of Agricultural Science
2025
Chambroad Chemical Industry Research Institute (China)
2025
National Synchrotron Radiation Laboratory
2024
University of Science and Technology of China
2024
Xiangya Hospital Central South University
2017-2023
Central South University
2017-2023
Jiangxi College of Applied Technology
2022
Fujian Academy of Agricultural Sciences
2022
Background and Aims: NAFLD has become a major metabolic disease worldwide. A few studies have reported the potential relationship between mitochondrial pyruvate carrier 1 (MPC1) inflammation, fibrosis, insulin sensitivity in obese or NASH mouse models. However, impact of MPC1 on NAFLD-related liver lipid metabolism its role progression require further investigation. Approach Results: expression was measured tissues from normal controls patients with NAFLD. We characterized phenotypes genes...
Scope Curcumin is a natural polyphenol compound with multiple pharmacologic activities. The present study aims to explore the potential therapeutic properties of curcumin on intestinal inflammatory diseases, including its anti‐inflammatory, antioxidant, and anti‐apoptotic properties, as well their associations altered microbiome. Methods Results DSS, i.e., Dextran Sulfate Sodium, (3%) administered C57BL/6J mice in drinking water daily for 6 days DSS groups. Then, groups are orally 50 or 150...
Abstract Nanozyme, characterized by outstanding and inherent enzyme-mimicking properties, have emerged as highly promising alternatives to natural enzymes owning their exceptional attributes such regulation of oxidative stress, convenient storage, adjustable catalytic activities, remarkable stability, effortless scalability for large-scale production. Given the potent regulatory function nanozymes on stress coupled with fact that reactive oxygen species (ROS) play a vital role in occurrence...
Increasing planting density is one of the most important strategies for generating higher maize yields. Moderate leaf rolling decreases mutual shading leaves and increases photosynthesis population hence tolerance high-density planting. Few genes that control in have been identified, however, their applicability breeding programs remains unclear. Here we identified a abaxially rolled leaf1 (arl1) mutant with extreme found size bulliform cells within adaxial blade surface increased arl1...
Gut microbiota represent an important bridge between environmental substances and host metabolism. Here we reported a comprehensive study of gut interaction with ochratoxin A (OTA), major food-contaminating mycotoxin, using the combination metagenomics culture-based methods. Rats were given OTA (0, 70, or 210 μg/kg body weight) by gavage fecal samples collected at day 0 28. Bacterial genomic DNA was extracted from both 16S rRNA shotgun sequencing (two main methods metagenomics) performed....
Improvement of hyperglycemia through dietotherapy/herbal remedy is an effective approach to treating diabetes. In this study, mulberry leaf, famous for silkworm's special food and therapeutic value without any side effects, alleviated diabetes by attenuating NEFA signaling modulating intestinal microflora. Mulberry leaf treatment significantly reduce fasting blood-glucose HbA1c, ameliorate the blood lipid profile improve insulin resistance in streptozotocin-induced diabetic rats....
Abstract The mycotoxin ochratoxin A (OTA) is found widely in agricultural commodities. OTA can induce various toxicities. In this study, rats were gavaged with for different weeks. Then, the expression of microRNAs, mRNAs and proteins measured rat livers treated 13 Our sequencing data suggests that medial high doses exert effects on livers. Five distinctive pathways induced after treatment as collectively demonstrated at miRNA, mRNA protein levels. Two (primary bile acid biosynthesis...
The increased prevalence of obesity significantly affects human health worldwide. Improvement glycometabolism by dietotherapy/herbal remedy is an effective approach to ameliorate obesity. In this study, high-fat-diet induced obese (DIO) mice were treated with mulberry leaves for 13 weeks. results showed that alleviated adiposity DIO including reducing body weight gain, fat accumulation and fasting blood glucose, improving insulin sensitivity. addition, had protective effects on liver...
The Soybean (Glycine max) leghemoglobin c2 (LegHb) gene was introduced into Pichia pastoris yeast for sustainable production of a heme-carrying protein, organoleptic use in plant-based meat. potential allergenicity and toxicity LegHb 17 host-proteins each representing ≥1% total protein batches are evaluated by literature review, bioinformatics sequence comparisons to known allergens or toxins, vitro pepsin digestion.
Abstract BACKGROUND Chlorogenic acid is a type of phenolic found in many plants. has an anti‐obesity effect with unclear mechanism. The present study aimed to investigate the regulatory chlorogenic on energy balance high‐fat diet (HFD) induced obese C57BL/6J mice administrated 100 mg kg –1 for 13 weeks. RESULTS consumption ameliorated HFD obesity. did not change physical activity but significantly decreased food intake and increased body temperature, thermal dissipation brown adipose tissue...
Caffeic acid (CFA), a natural polyphenolic compound which exists in coffee, fruits and certain traditional Chinese medicine, is one promising anti-obesity agent with variety of pharmacological activities. The objective the current study was to determine mechanism effect CFA, relationship between its gut microbiota change high fat diet induced obese (DIO) mice. DIO mice were administrated CFA by daily gavage at 50 mg/kg body weight for 12 weeks. results showed that significantly ameliorated...
Abstract Background Microbial fermentation significantly affects the flavor and efficacy of tea. It is generally believed that fermented tea more effective in lowering lipids, while unfermented can effectively inhibit inflammation. However, there not sufficient evidence to support this claim. To systematically compare hypolipidemic, anti‐inflammatory, anti‐atherosclerotic effects before after microbial fermentation, hyperlipidemic rats inflammatory injury cells were treated with Monascus...
Nanoscale cerium oxide has excellent catalytic performance due to its unique surface properties and very important applications in various fields. In this paper, the synthesis methods, mechanism activity regulation of nanoscale recent years are reviewed. Secondly, application detection organic inorganic molecules is summarized, latest progress antibacterial, antioxidant anticancer discussed. Finally, future development prospect summarized prospected.
Pleurotus ostreatus (PO), a common edible mushroom, contains rich nutritional components with medicinal properties. To explore the effect of PO on ameliorating obesity and modulating gut microbiota, we administered mice low-fat diet or high-fat containing different dosages (mass fraction: 0%, 2.5%, 5% 10%). The body weight, adipose tissue GTT, ITT, blood lipids, serum biomarkers liver/kidney function, microbiota function were measured analyzed after 6 weeks treatment. results showed...