A5074486459- Selenium in Biological Systems
- Trace Elements in Health
- DNA Repair Mechanisms
- Heavy Metal Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Telomeres, Telomerase, and Senescence
- Glutathione Transferases and Polymorphisms
- Gut microbiota and health
- Birth, Development, and Health
- Organoselenium and organotellurium chemistry
- Phytase and its Applications
- Food Industry and Aquatic Biology
- Medical and Biological Ozone Research
- Redox biology and oxidative stress
- Mycotoxins in Agriculture and Food
- Genomics and Chromatin Dynamics
- Cancer, Lipids, and Metabolism
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Genomics, phytochemicals, and oxidative stress
- Diet and metabolism studies
- Plant Genetic and Mutation Studies
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
Texas Woman's University
2025
Mississippi State University
2015-2024
University of Maryland, College Park
2008-2019
Jiangnan University
2018-2019
University of Hong Kong
2018
Center for Nutrition Policy and Promotion
2017
Alexandra Institute (Denmark)
2010
Vestergaard (Switzerland)
2010
National Institute on Aging
2003-2008
National Institutes of Health
2003-2008
Werner syndrome (WS) is an inherited disorder characterized by premature onset of aging, genomic instability, and increased cancer incidence. The disease caused loss function mutations the WRN gene, a RecQ family member with both helicase exonuclease activities. However, despite its putative tumor-suppressor function, little known about contribution to human sporadic malignancies. Here, we report that abrogated in cells transcriptional silencing associated CpG island-promoter...
A defect in the Werner syndrome protein (WRN) leads to premature aging disease (WS). Hallmark features of cells derived from WS patients include genomic instability and hypersensitivity certain DNA-damaging agents. WRN contains a highly conserved region, RecQ domain, that plays central role interactions. We searched for proteins bound this most prominent direct interaction was with poly(ADP-ribose) polymerase 1 (PARP-1), nuclear enzyme protects genome by responding DNA damage facilitating...
Gut microbiota represent an important bridge between environmental substances and host metabolism. Here we reported a comprehensive study of gut interaction with ochratoxin A (OTA), major food-contaminating mycotoxin, using the combination metagenomics culture-based methods. Rats were given OTA (0, 70, or 210 μg/kg body weight) by gavage fecal samples collected at day 0 28. Bacterial genomic DNA was extracted from both 16S rRNA shotgun sequencing (two main methods metagenomics) performed....
Abstract The mycotoxin ochratoxin A (OTA) is found widely in agricultural commodities. OTA can induce various toxicities. In this study, rats were gavaged with for different weeks. Then, the expression of microRNAs, mRNAs and proteins measured rat livers treated 13 Our sequencing data suggests that medial high doses exert effects on livers. Five distinctive pathways induced after treatment as collectively demonstrated at miRNA, mRNA protein levels. Two (primary bile acid biosynthesis...
Campylobacter is one of the main bacterial pathogens that cause campylobacteriosis in United States. Poultry considered a major reservoir for transmission to humans. This study aimed determine prevalence and molecular characteristics no-antibiotics-ever (NAE) broilers. A total 414 samples were collected, among which 160 retail chicken purchased from grocery stores 254 collected broiler farms located Mississippi State. The overall was 25.4%, significantly higher observed than farm (36.3%...
The Werner syndrome and the Nijmegen breakage are recessive genetic disorders that show increased genomic instability, cancer predisposition, hypersensitivity to mitomycin C γ-irradiation, shortened telomeres, cell cycle defects. protein mutated in premature aging disease known as is designated WRN a member of RecQ helicase family. Nbs1 individuals part mammalian Mre11 complex together with Rad50 proteins. Here, we associates via binding vitro vivo. In response γ-irradiation or C, leaves...
Werner syndrome (WS) is a human genetic disorder characterized by extensive clinical features of premature aging. Ataxia-telengiectasia (A-T) multisystem genomic instability that includes aging in some the patients. WRN and ATM, proteins defective WS A-T, respectively, play significant roles maintenance stability are involved several DNA metabolic pathways. A role for repair has been proposed; however, this study provides evidence also ATM pathway activation S-phase checkpoint cells exposed...
Selenium chemoprevention by apoptosis has been well studied, but it is not clear whether selenium can activate early barriers of tumorigenesis, namely senescence and DNA damage response. To test this hypothesis, we treated normal cancerous cells with a gradient concentration sodium selenite, methylseleninic acid methylselenocysteine for 48 h, followed recovery 1-7 days. Here show that compounds at doses </=LD(50) induce cellular senescence, as evidenced the expression senescence-associated...
Ochratoxin A (OTA) and Zearalenone (ZEA) are widespread mycotoxins that contaminate foodstuffs simultaneously, but sufficient data regarding their mixed toxicities lacking. This study aims to analyze the style of combined effects OTA ZEA on cells target organs. For this purpose, cytotoxicity was determined in HepG2 KK-1 treated with single forms ZEA. Furthermore, we have analyzed using two mathematical models based concepts concentration addition (CA) independent (IA). By analyzing nonlinear...
Nephrotoxicity is the most prominent one among various toxicities of ochratoxin A (OTA). MicroRNAs (miRNAs) are small non-coding RNAs that have an impact on a wide range biological processes by regulating gene expression at post-transcriptional level or protein systhesis level. The objective this study to analyze miRNA profiling in kidneys rats gavaged with OTA.To profile miRNAs OTA nephrotoxicity, high-throughput sequencing and bioinformatics approaches were applied kidney following...
Butyrate, an intestinal microbiota metabolite of dietary fiber, exhibits chemoprevention effects on colon cancer development. However, the mechanistic action butyrate remains to be determined. We hypothesize that inhibits cancerous cell proliferation but a lesser extent in noncancerous cells through regulating apoptosis and cellular-signaling pathways. tested this hypothesis by exposing HCT116 or non-cancerous NCM460 physiologically relevant doses butyrate. Cellular responses were...