A5071616200- Phytoestrogen effects and research
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Cancer Risks and Factors
- Alcohol Consumption and Health Effects
- Cancer, Lipids, and Metabolism
- Pharmacogenetics and Drug Metabolism
- Dietetics, Nutrition, and Education
- Gut microbiota and health
- Nutrition and Health in Aging
- Cardiovascular Disease and Adiposity
- Diabetes Management and Education
- Folate and B Vitamins Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Child Nutrition and Feeding Issues
- Food Security and Health in Diverse Populations
- Obesity and Health Practices
- Metabolomics and Mass Spectrometry Studies
- Protein Hydrolysis and Bioactive Peptides
University of Arkansas for Medical Sciences
2015-2024
Arkansas Children's Hospital
2015-2024
East Carolina University
2019
University of Arkansas at Fayetteville
2019
College of New Jersey
2018
Universidad Autónoma de Nuevo León
2018
California State University, Long Beach
2018
Heidelberg University
2018
University Hospital Heidelberg
2018
Arkansas Department of Education
2017
Butyrate, an intestinal microbiota metabolite of dietary fiber, exhibits chemoprevention effects on colon cancer development. However, the mechanistic action butyrate remains to be determined. We hypothesize that inhibits cancerous cell proliferation but a lesser extent in noncancerous cells through regulating apoptosis and cellular-signaling pathways. tested this hypothesis by exposing HCT116 or non-cancerous NCM460 physiologically relevant doses butyrate. Cellular responses were...
Nutritional status is a primary factor in the effects of xenobiotics and may be an important consideration development safety standards assessment risk. One xenobiotic consumed daily by millions people worldwide alcohol. Some adverse ethanol, such as alcohol liver disease, have been linked to diet. For example, ethanol-induced hepatotoxicity animal models requires diets that high percentage total calories unsaturated fat. However, little attention has given role carbohydrates (or...
Abstract Introduction High body mass index has been associated with increased risk for various cancers, including breast cancer. Here we describe studies using 7,12-dimethylbenz( a )anthracene (DMBA) to investigate the role of obesity in DMBA-induced mammary tumor susceptibility female Zucker rat ( fa/fa ), which is most widely used model genetic obesity. Method Fifty-day-old obese n = 25) and lean 28) rats were orally gavaged 65 mg/kg DMBA. Rats weighed palpated twice weekly detection...
Continuous intragastric infusion of ethanol has been reported to result in episodic daily blood alcohol concentrations male rats (Tsukamoto et al., 1985). We have used a total enteral nutrition (TEN) model study the effects chronic exposure on and urine adult Sprague Dawley (300 g). Two TEN models were studied: 1) continuous which complete diet was infused i.g. for 24 h/day; or 2) cyclic intragastrically 12 h/day (i.e., only during dark phase lighting cycle). In model, (BACs) determined at...
Non-alcoholic fatty liver disease is a common disorder worldwide and associated with obesity. We investigated effects of obesity short-term intake soy protein isoflavones (SPI) on body weight change, energy intake, steatosis, serum aspartate aminotransferase (AST), alanine (ALT), leptin levels. Seventeen lean seventeen obese (fa/fa) female Zucker rats were randomly assigned to either casein or SPI diet for 8 weeks. Body was recorded twice weekly; feed measured weekly. Livers examined...
Obesity has been on the rise in US and worldwide for last several decades. associated with chronic disease development, such as certain types of cancer, type 2 diabetes, cardiovascular disease, liver diseases. Previously, we reported that obesity promotes DMBA-induced mammary tumor development using obese Zucker rat model. The intestinal microbiota is composed a diverse population obligate facultative anaerobic microorganisms, these organisms carry out broad range metabolic activities....
Dietary factors other than the traditional nutrients are found in so-called functional foods. They becoming increasingly recognized as potentially important for maintaining good health. Soybeans rich such thought to help prevent certain chronic diseases. Soy protein isolate (SPI) is one of three major proteins used infant formulas sold United States, with casein (CAS) and whey (WPH) being others. We have been studying health effects these proteins. Safety concerns developed over consumption...
Chronic alcohol abuse decreases bone mass, inhibits osteoblast differentiation and function, increases fracture incidence, delays healing. Four studies were designed to use intragastric ethanol delivery as part of a total enteral nutrition (TEN) system determine the negative systemic effects chronic on 1) rat skeleton 2) local rapid formation during limb lengthening (distraction osteogenesis, DO). In study 1, three-point bending tests demonstrated that after 75 days exposure, tibiae had...
The intragastric administration of ethanol as part a lowcarbohydrate diet results in alcohol hepatotoxicity. We aimed to investigate whether comparable liver injury can be achieved by oral intake. Male Sprague-Dawley rats were fed low-carbohydrate diets for 36–42 days either intragastrically or orally. Liver pathology, blood concentration, serum alanine amino transferase (ALT), endotoxin level, hepatic CYP2E1 induction, and cytokine profiles assessed. Both resulted marked steatosis with...
Non-alcoholic fatty liver disease (NAFLD), is one of the main diseases in US and world which often related to obesity. Previously, we reported short- long-term consumption soy protein isolate diet with high isoflavones can reduce steatosis male female obese Zucker rat model. However, effects vs. low on NAFLD less known. The objectives present study were examine role levels concentrate diets protection against an Forty-two 6-week old lean (L, n = 21) (O, rats randomly assigned 1 3 dietary...
Obesity is associated with increased risk for postmenopausal, but not premenopausal breast cancer. Recently, we reported that intact obese Zucker rats had susceptibility to DMBA-induced mammary tumors compared lean rats. In the present study, investigated whether excessive adipose tissue would promote tumor induction in absence of ovarian estrogen. Lean and were sham-operated or ovariectomized at 40 days old gavaged 50 65 mg/kg DMBA. Rats weighed palpated twice weekly detection sacrificed...