A5052165147- Gut microbiota and health
- Probiotics and Fermented Foods
- Proteins in Food Systems
- Protein Hydrolysis and Bioactive Peptides
- Phytochemicals and Antioxidant Activities
- Selenium in Biological Systems
- Infant Nutrition and Health
- Tea Polyphenols and Effects
- Fungal Biology and Applications
- Diet and metabolism studies
- Microencapsulation and Drying Processes
- Diet, Metabolism, and Disease
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Phytoestrogen effects and research
- Trace Elements in Health
- Clostridium difficile and Clostridium perfringens research
- Biochemical Analysis and Sensing Techniques
- CRISPR and Genetic Engineering
- Microbial Metabolites in Food Biotechnology
- Food Chemistry and Fat Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Nanomaterials in Catalysis
- Polysaccharides and Plant Cell Walls
Jilin University
2016-2025
China Pharmaceutical University
2024
Hunan University of Science and Engineering
2013-2023
Yunnan University
2023
Shandong University
2021
Central South University
2020
Seascape Consultants (United Kingdom)
2020
Caterpillar (United States)
2020
Jilin Medical University
2017
University of Maryland, College Park
2014-2016
Abstract Alliin (S-allyl cysteine sulfoxide) is a bioactive sulfoxide compound derived from garlic. To evaluate the preventive effect of alliin against metabolic risk factors in diet induced obese (DIO) mice, we treated C57BL/6J DIO mice with drinking water or without (0.1 mg/ml) for 8 weeks. Results showed that had no significant on body weight, adiposity energy balance. However, treatment enhanced glucose homeostasis, increased insulin sensitivity and improved lipid profile mice. This was,...
Pre-heated whey protein isolate (WPI) solution (10% w/v, 85°C for 30min) was prepared and subjected to high-intensity ultrasound (HUS, 20kHz) at different durations (5-40min) before acidification determine the effects of HUS on glucono-δ-lactone (GDL)-induced gelation properties gel. Results showed that reduced particle size increased surface free sulfhydryl groups pre-heated solution. Free (-SH) content acid-induced WPI gels (GIWG) solubility in presence 8M urea were significantly (P<0.05)...
Amyloid-like assembly is not only associated with pathological events, but also leads to the development of novel nanomaterials unique properties. Herein, using Fmoc diphenylalanine peptide (Fmoc-F-F) as a minimalistic model, we found that histidine can modulate behavior Fmoc-F-F and induce enzyme-like catalysis. Specifically, presence rearranges β structure assemble nanofilaments, resulting in formation active site mimic peroxidase-like activity catalyzes ROS generation. A similar catalytic...
Abstract The challenge in treating diabetic foot infections caused by drug‐resistant bacteria is rapidly eradicating and accelerating wound healing. NIR‐II‐induced photothermal therapy (PTT) offers notable advantages over conventional treatments, such as broad‐spectrum bactericidal efficacy, better penetration depth biological tissues, higher skin tolerance thresholds, making it particularly suitable for addressing infections. Herein, found that NIR‐II dye IR26 exhibited good effects but...
Lutein is a hydrophobic carotenoid that has multiple health functions. However, the application of lutein limited due to its poor solubility in water and instability under certain conditions during storage. Hereby we generated loaded nano-emulsions using whey protein isolate (WPI) or polymerized (PWP) with assistance high intensity ultrasound evaluate their stability storage at different conditions. We measured particle size, zeta-potential, physical content change. Results showed PWP based...
Probiotics are considered to be a potential treatment for ulcerative colitis (UC). The aim of this study was compare the preventive effect space flight-induced mutant L. reuteri F-9-35 and its wild type on UC in vivo. Female mice were randomly assigned five groups: one normal four colitic. Mice from groups daily gavaged with 0.2 mL 12% (w/v) skim milk containing or (1 × 1011 CFU/mL), alone distilled water whole experiment period, starting 7 days before induction. induced by administrating...
Astaxanthin nanodispersion was prepared using whey protein isolate (WPI) and polymerized (PWP) through an emulsification–evaporation technique. The physicochemical properties of the astaxanthin were evaluated, transport assessed a Caco-2 cell monolayer model. nanodispersions stabilized by WPI PWP (2.5%, w/w) had small particle size (121 ± 4.9 80.4 5.9 nm, respectively), negative ζ potential (−19.3 1.5 −35.0 2.2 mV, high encapsulation efficiency (92.1 2.9 93.5 2.4%, respectively)....
Abstract BACKGROUND Chlorogenic acid is a type of phenolic found in many plants. has an anti‐obesity effect with unclear mechanism. The present study aimed to investigate the regulatory chlorogenic on energy balance high‐fat diet (HFD) induced obese C57BL/6J mice administrated 100 mg kg –1 for 13 weeks. RESULTS consumption ameliorated HFD obesity. did not change physical activity but significantly decreased food intake and increased body temperature, thermal dissipation brown adipose tissue...
Whey protein is a fraction of milk that has both nutritional and health boosting effects. Hydrolyzation whey by enzyme or fermentation can generate bioactive peptides are beneficial to the life activities and/or regulate physiological functions. Though been widely applied in food industry, many newly developed peptide products with multiple bioactivities come up commercial market from research labs. In this paper, we systematically discussed general production flow peptides, found their...
The gut barrier plays an important role in health maintenance by preventing the invasion of dietary pathogens and toxins. Disruption can cause severe intestinal inflammation. As a natural source, milk is enriched with many active constituents that contribute to numerous beneficial functions, including immune regulation. These components collectively serve as shield for barrier, protecting against various threats such biological, chemical, mechanical, immunological threats. This comprehensive...
Abstract Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase (MAPKKK, MAP3K) family member that plays an important role oxidative stress-induced cell apoptosis. In this study, we performed RNA interference of ASK1 HEK293 cells employed iTRAQ-based quantitative proteomics approach to globally investigate the regulatory mechanism OTA-induced Our results showed knockdown...
Obesity has become one of the most important health problems worldwide requiring urgent need for efficient control. Pleurotuscitrinopileatus (P. citrinopileatus)-a type edible mushroom with abundant bioactive molecules-is a promising source achieving this goal. In present study, we evaluated anti-obesity and hypolipidemic effect P. citrinopileatus water extract (PWE) using series biochemical assays in randomized high-fat diet-induced obese (DIO) C57BL/6J mice, which were gavaged daily low or...
Abstract The nonalcoholic fatty liver disease (NAFLD) is a progressive that affects the health of people in an increasing rate. In current research, we investigated beneficial effect novel probiotic strain L. paracasei Jlus66 (Jlus66) on rats with high‐fat diet (HFD)‐induced NAFLD. intestinal flora was analyzed based V3‐V4 region 16S rDNA sequencing. Moreover, measured oxidative stress and inflammation factors using commercial ELISA kit, lipopolysaccharide (LPS) serum chromogenic end‐point...