A5063583435- Proteins in Food Systems
- Microencapsulation and Drying Processes
- Cutaneous Melanoma Detection and Management
- Streptococcal Infections and Treatments
- Bone health and osteoporosis research
- Neurological Disease Mechanisms and Treatments
- Antioxidant Activity and Oxidative Stress
- Toxin Mechanisms and Immunotoxins
- Meat and Animal Product Quality
- Nonmelanoma Skin Cancer Studies
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects of Natural Compounds
- Vitamin D Research Studies
- Microbial Inactivation Methods
- Neurological Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- Psoriasis: Treatment and Pathogenesis
- Genetic and rare skin diseases.
- Cerebrovascular and Carotid Artery Diseases
- Dermatological diseases and infestations
- melanin and skin pigmentation
- Cancer and Skin Lesions
- Pharmaceutical and Antibiotic Environmental Impacts
- Cardiovascular Health and Disease Prevention
- Protein Interaction Studies and Fluorescence Analysis
Jilin University
2016-2025
Jinzhou Medical University
2024
Chengdu Second People's Hospital
2019-2023
China Tobacco
2023
Institute of High Energy Physics
2022
First Affiliated Hospital of Anhui Medical University
2017-2020
Anhui Medical University
2017-2020
First Hospital of Jilin University
2018-2019
Shandong Provincial QianFoShan Hospital
2015-2019
Shandong University of Traditional Chinese Medicine
2015-2019
Pre-heated whey protein isolate (WPI) solution (10% w/v, 85°C for 30min) was prepared and subjected to high-intensity ultrasound (HUS, 20kHz) at different durations (5-40min) before acidification determine the effects of HUS on glucono-δ-lactone (GDL)-induced gelation properties gel. Results showed that reduced particle size increased surface free sulfhydryl groups pre-heated solution. Free (-SH) content acid-induced WPI gels (GIWG) solubility in presence 8M urea were significantly (P<0.05)...
A solution (10%, w/v) of whey protein soluble aggregates (WPISA) was pretreated with high-intensity ultrasound (HUS, 20 kHz) for different durations (10-40 min) before incubation transglutaminase (TGase) to investigate the effect HUS on structural, physicochemical, rheological, and gelation properties TGase cross-linked WPISA. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) results showed that increased amounts high-molecular-weight polymers/aggregates in WPISA after...
Summary Use of high‐intensity ultrasound to modify certain functional properties whey proteins is an alternative traditional method in food industry. Whey protein isolate ( WPI ) solutions were treated with probe (20 kHz) at different intensities (20% or 30% amplitude) and durations (10 20 min). Results showed that treatment changed physical several including decreased particle size (from 190.4 nm 138.0 nm), increased surface hydrophobicity 5.13 × 10 5 5.77 ), free sulphydryl groups 52.64...
Lutein is a hydrophobic carotenoid that has multiple health functions. However, the application of lutein limited due to its poor solubility in water and instability under certain conditions during storage. Hereby we generated loaded nano-emulsions using whey protein isolate (WPI) or polymerized (PWP) with assistance high intensity ultrasound evaluate their stability storage at different conditions. We measured particle size, zeta-potential, physical content change. Results showed PWP based...
Astaxanthin nanodispersion was prepared using whey protein isolate (WPI) and polymerized (PWP) through an emulsification–evaporation technique. The physicochemical properties of the astaxanthin were evaluated, transport assessed a Caco-2 cell monolayer model. nanodispersions stabilized by WPI PWP (2.5%, w/w) had small particle size (121 ± 4.9 80.4 5.9 nm, respectively), negative ζ potential (−19.3 1.5 −35.0 2.2 mV, high encapsulation efficiency (92.1 2.9 93.5 2.4%, respectively)....
Abstract Biofilm formation mediated by sortase A (srtA) is important for bacterial colonisation and resistance to antibiotics. Thus, the inhibitor of SrtA may represent a promising agent infection. The structure Streptococcus pneumoniae D39 srtA has been characterised crystallisation. Site‐directed mutagenesis was used determination key residues activity S. srtA. An effective inhibitor, quercetin, its mechanism further identified using inhibition assay molecular modelling. In this study,...
Artificial intelligence (AI) had been first coined at a famous Dartmouth College conference in 1956. AI is gradually interrelated with all disciplines, and also permeates aspects of the medical field. In early 1970s, researchers discovered applicability life sciences.[1] can play role many aspects, such as image recognition auxiliary diagnosis,[2] biotechnology,[3] drug research development,[4] etc. Currently, most widely used. Dermatology subject that relies on morphological features,...
Lactoferrin is widely found in milk and has the ability to bind iron. Previous studies have reported that lactoferrin was effective prevention treatment of acute alcohol-induced liver injury (AALI). Ferroptosis a recently discovered cell death involved development AALI. However, potential role ferroptosis still unclear. In this study, we observed (10, 20, 40 μg/mL) significantly mitigated alcohol (300 mM)-induced vitro. Additionally, (100 200 mg/kg BW) alleviated (4.8 g/kg BW)-induced vivo....
Astaxanthin, a natural pigment carotenoid, is well known for its potential benefits to human health. However, applications in the food industry are limited, due poor water-solubility and chemical instability. Six different emulsifiers were used prepare astaxanthin-loaded emulsions, including whey protein isolate (WPI), polymerized (PWP), WPI-lecithin, PWP-lecithin, lecithin, Tween20. The droplet size, zeta potential, storage stability, cytotoxicity, astaxanthin uptake by Caco-2 cells all...
Streptococcus suis, an important zoonotic pathogen, has caused considerable economic losses in the swine industry and severe public health issues worldwide. The development of a novel effective strategy for prevention therapy S. suis is urgently needed. Here, amentoflavone, natural biflavonoid compound isolated from Chinese herbs that negligible anti-S. activity, was identified as potent antagonist suilysin (SLY)-mediated hemolysis without interfering with expression SLY. Amentoflavone...
Background: Artificial intelligence (AI) has become a powerful tool and is attracting more attention in the field of medicine. There are number AI studies focusing on skin diseases, there many products that have been applied dermatology. However, attitudes dermatologists, specifically those from China, towards AI, not clear as few, if any focused this issue. Methods: A web-based questionnaire was designed by experts Chinese Skin Image Database (CSID) published UMER Doctor platform (an online...
Abstract Context Bone mineral density (BMD) T-score references may be updated when the peak BMD of population is unclear and warrants reevaluation. Objective To update using from most recent National Health Nutrition Examination Survey (NHANES) data. Methods This cross-sectional study used NHANES data 2005 to 2014. Non-Hispanic White females between ages 10 40 years (N = 1549) were our target estimate (SD). Individuals aged ≥ 50 5523) compare percentages osteoporosis low bone mass based on...
The usage of food-derived polyphenols with different polarities has been limited by their instability and incompatibility. Therefore, a biocarrier was developed co-assembly whey protein isolate (WPI) hydrophilic proanthocyanidin (PC) for loading hydrophobic pterostilbene (PTE). Such superior affinity PTE than WPI alone, as determined encapsulation efficiency capacity assay, fluorescence quenching analysis, molecular docking, whereas the assembly process characterized particle size zeta...
Protein-stabilized high internal phase Pickering emulsions (HIPPEs) as edible 3D food printing materials have various applications within the industry. Herein, whey protein-based nanoparticles with Curcumin (Cur) and different amount of Proanthocyanins (PC) incorporated exerted reduced surface tension, enhanced particle size, Cur loading efficiency, 3-phase contact angle, interfacial protein adsorption, load increasing PC content, making them excellent stabilizers for HIPPEs. The formed...
This study investigated the effect of ultrasound and enzymatic cross-linking on freeze-thaw (FT) stability release properties whey protein isolate hydrogels. We evaluated FT by changes in microstructure, riboflavin retention, syneresis, water holding capacity (WHC), texture gels subjected to 3 cycles. High-intensity (HUS) transglutaminase (TGase)-mediated improved hydrogels loaded with (WPISAR), as demonstrated a more uniform denser porous structure, significantly higher WHC, textural...
Diabetic nephropathy is the primary cause of end-stage renal disease. Apoptosis tubule epithelial cells a major feature diabetic nephropathy. The mechanisms high glucose (HG) induced apoptosis are not fully understood. Here we demonstrated that, HG via upregulating expression proapoptotic Bcl-2 homology domain 3 (BH3)-only protein Bim protein, but bring significant change in baseline level autophagy HK2 cells. increase was caused by ugregulation transcription factors, FOXO1 and FOXO3a....