A5100359472- CRISPR and Genetic Engineering
- Brucella: diagnosis, epidemiology, treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Gastric Cancer Management and Outcomes
- Animal Diversity and Health Studies
- TGF-β signaling in diseases
- Crystal structures of chemical compounds
- Reproductive biology and impacts on aquatic species
- Aquaculture Nutrition and Growth
- Synthesis and biological activity
- Metastasis and carcinoma case studies
- Bacteriophages and microbial interactions
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Escherichia coli research studies
- Microbial Natural Products and Biosynthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Antifungal resistance and susceptibility
- Traditional Chinese Medicine Analysis
- Adipose Tissue and Metabolism
- Electrochemical Analysis and Applications
- Phytochemistry and Biological Activities
Hunan Normal University
2018-2025
Model Animal Research Center
2024-2025
Nanjing University
2024-2025
Henan Polytechnic University
2020-2024
Guangdong Medical College
2024
Guangdong University of Petrochemical Technology
2024
Guilin University of Electronic Technology
2024
State Key Laboratory of Pharmaceutical Biotechnology
2024
Northwest A&F University
2023-2024
Guiyang College of Traditional Chinese Medicine
2024
Abstract Heat removal and thermal management are critical for the safe efficient operation of lithium-ion batteries packs. Effective dynamically generated heat from cells presents a substantial challenge optimization. This study introduces novel liquid cooling method aimed at improving temperature uniformity in battery pack. A complex nonlinear hybrid model is established through traditional full-factor design back propagation neural network (BPNN) approximation. links input parameters such...
Abstract This study proposes a stepped-channel liquid-cooled battery thermal management system based on lightweight. The impact of channel width, cell-to-cell lateral spacing, contact height, and angle the effectiveness control (TCS) is investigated using numerical simulation. weight sensitivity factor adopted to evaluate effect TCS (mTCS) maximum temperature (Tmax) pack. Results suggest that width plays most critical role, followed by spacing angle, while height has minimal influence. Four...
Abstract We describe here a CRISPR simultaneous and wide-editing induced by single system (SWISS), in which RNA aptamers engineered crRNA scaffold recruit their cognate binding proteins fused with cytidine deaminase adenosine to Cas9 nickase target sites generate multiplexed base editing. By using paired sgRNAs, SWISS can produce insertions/deletions addition Rice mutants are generated the efficiencies of cytosine conversion 25.5%, adenine 16.4%, indels 52.7%, triple mutations 7.3%. The...
Acute kidney injury is a common complication of major surgery. However, acute occurring within the first 48 hours after surgery (early injury) and therefore likely related to itself possibly different from (late injury). The aim this study was describe epidemiology identify differences in risk factors outcomes between early late following surgery.Retrospective cohort study.Academic Medical Center.Patients admitted ICU noncardiac surgery.None.We analyzed data 3,499 patients defined according...
Abstract. Proglacial lakes are rapidly expanding due to climate change and glacier retreat. Eukaryotic microorganisms play a crucial role in the biogeochemical cycles of these lakes. However, there is limited understanding formation processes eukaryotic microbial communities their responses material cycling proglacial lakes, which land reservoirs new habitats for biological evolution meltwater, particularly at different developmental stages. This study investigates distribution patterns...
This study aimed to investigate the associations between chrononutrition profile, social jet lag (SJL) with obesity-related indicators (body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHTR), and percentage of body fat (PBF)). cross-sectional was conducted among college students in a university Hunan Province, China, from 14 September 2023 8 June 2024. employed Chrononutrition Profile – Questionnaire (CP-Q) along physical examinations. SJL defined as time difference...
Armillaria gallica establish a unique symbiotic relationship with Gastrodia elata, which is valuable Chinese herbal plant that relies on this symbiosis. High temperature (HT) seriously affected the growth of both A. and G. elata. However, molecular mechanisms gene networks involved in response to HT are not well understood. In study, transcriptomic analyses at multiple time point were conducted using rhizomorph from two strains, GZ1 (tolerance HT) SX8 (sensitive under normal (NT) conditions....
Loss of function parkin leads to the mitochondrial dysfunction, which is closely related Parkinson's disease. However, in vivo mechanism far from clear. One dogmas that impaired Parkin causes dysfunction mitophagy mediated by Pink1-Parkin axis. The other Mfn accumulation dysfunction. Surprisingly, Drosophila muscles, as reported, first dogma not applicable; for second dogma, our study suggests mediates through modulating morphology, determined synergy both Marf and protein mRpL18 got...
Systemic fungal infections contribute to at least 10% of deaths in hospital settings. Most antifungal drugs target ergosterol (polyenes) or its biosynthetic pathway (azoles and allylamines), beta-glucan synthesis (echinocandins). Antifungal that proteins are prone the emergence resistant strains. Identification genes whose mutations lead targeted resistance can provide new information on those pathways. We used Aspergillus nidulans as a model system exploit tractable sexual cycle calcofluor...
Preadipocyte determination expanding the pool of preadipocytes is a vital process in adipocyte hyperplasia, but molecular mechanisms underlying this are yet to be elucidated. Herein, SRY-related HMG box transcription factor 4 (SOX4) was identified as critical target response BMP4- and TGFβ-regulated preadipocyte determination. SOX4 deficiency sufficient promote mesenchymal stem cells (MSCs) acquisition properties nonadipogenic lineages, while its overexpression impairs adipogenic capacity...
A Gram-stain-negative, rod-shaped, strictly aerobic, motile bacterial strain, designated YM319T, was isolated from a seamount near the Yap Trench in tropical western Pacific. Phylogenetic analysis based on 16S rRNA gene sequence showed that strain YM319T related to genus Oceanisphaera and had highest similarities with type strains profunda SM1222T (97.4 %), sediminis TW92T (97.3 %) ostreae T-w6T (97.1 %). The predominant cellular fatty acids were summed feature 3 (composed of iso-C15 : 0...