A5101782029- Plant Diversity and Evolution
- Plant and Fungal Species Descriptions
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Phytochemistry and Bioactive Compounds
- Cancer-related molecular mechanisms research
- Olfactory and Sensory Function Studies
- Phytochemistry and Biological Activities
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer Treatment and Pharmacology
- Prenatal Substance Exposure Effects
- Cancer, Hypoxia, and Metabolism
- Enzyme Catalysis and Immobilization
- Genetic Syndromes and Imprinting
- Pharmacological Effects of Natural Compounds
- Meat and Animal Product Quality
- Plant Pathogens and Fungal Diseases
- Advanced Chemical Sensor Technologies
- Galectins and Cancer Biology
- Signaling Pathways in Disease
- Genomics, phytochemicals, and oxidative stress
- Biological Control of Invasive Species
Fudan University
2020-2024
Tianjin Chest Hospital
2020-2024
Tianjin Medical University
2019-2024
Tibet Academy of Agricultural and Animal Husbandry Sciences
2018-2024
Dalian University
2018-2024
National Health and Family Planning Commission
2024
National Institute for Parasitic Diseases
2024
Yangzhou University
2024
State Key Laboratory of Biotherapy
2023
Sichuan University
2023
Evidence suggests that fasting exerts extensive antitumor effects in various cancers, including colorectal cancer (CRC). However, the mechanism behind this response is unclear. We investigate effect of on glucose metabolism and malignancy CRC. find upregulates expression a cholesterogenic gene, Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1), during inhibition CRC cell aerobic glycolysis proliferation. In addition, downregulation FDFT1 correlated with malignant progression poor prognosis...
Postmenopausal osteoporosis (PMOP) has long been a pervasive public health concern. With the aging Chinese population, prevention, assessment and management of postmenopausal were particularly important. During breastfeeding, large amount Calcium loss from maternal bone for infants' growth. However, whether this is completely reversible remains controversial. As relationship between breastfeeding different society to not clear literature, purpose study was determine an independent factor...
Abdominal aortic aneurysm (AAA) is characterized as dilation of the wall. Dysregulation vascular smooth muscle cells (VSMCs) can contribute to development this phenotype. Circular RNAs and microRNAs (miRNAs) regulate proliferation apoptosis VSMCs. This present study aimed identify mechanisms action behind regulation cerebellar degeneration‑related protein 1 antisense RNA (CDR1as)/miRNA (miR)‑7 in The expression levels miR‑7 were upregulated, whereas CDR1as cytoskeleton‑associated 4 (CKAP4)...
Abstract The great saphenous vein is the most commonly used vessel for coronary artery bypass grafting (CABG), but its use has been associated with a high restenosis rate at 10-year follow-up. This study sought to determine key genes graft that could serve as novel therapeutic targets. A total of 3075 upregulated and 1404 downregulated were identified after transcriptome sequencing three pairs restenosed grafts intraoperative spare veins. Weighted gene co-expression network analysis showed...
Prostate cancer is the most common illness affecting men worldwide. Although much progress has been made in study of prostate prevention and treatment, less attention paid to molecular mechanism disease. The arrangement by which atractylenolide II (ATR II) induces human cytotoxicity was comprehensively examined present study. As indicated results, ATR could inhibit cell proliferation promote DU145 LNCaP apoptosis through induced G2/M cycle arrest. process both cells associated with its...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces direct cytopathic effects, complicating the establishment of low-cytotoxicity cell culture models for studying its replication. We initially developed a DNA vector-based replicon system utilizing CMV promoter to generate recombinant viral genome bearing reporter genes. However, this frequently resulted in drug resistance and cytotoxicity, impeding model establishment. Herein, we present novel with SARS-CoV-2 replication...
Although paternal ethanol (EtOH) abuse has been shown to affect the growth and behavior of offspring, exact molecular mechanistic basis remains largely unclear. Methylation alterations in imprinted genes may be related well-documented teratogenic effects ethanol. Here we show that chronic exposure increases susceptibility abnormal offspring through male game epigenetic alteration. In our study, different doses (0, 1.1, 3.3 g kg-1 ) were administered intra-gastrically mice decreased sperm...
Olfactory dysfunctions, including hyposmia and anosmia, affect ~100 million people around the world underlying causes are not fully understood. Degeneration of olfactory sensory neurons incapacity globose basal cells to generate found in elder patients with smell disorders. Thus, stem cell may function as a promising tool replace inactivated neurons. Methods: We established clonal expansion from murine epithelium well colony growth human mucosa using Matrigel-based three-dimensional system....
Cell proliferation and casein synthesis of dairy cow mammary epithelial cells (DCMECs) are regulated by many factors. This research aimed to investigate the effect 14-3-3ε on cell in DCMECs reveal underlying mechanism. Overexpressing or inhibiting demonstrated that proliferation; synthesis; expression mTOR, p-mTOR, S6K1, p-S6K1; lysosomal localization mTOR were all up-regulated overexpressing down-regulated inhibiting. In addition, up-regulation response was removed mTOR. Furthermore,...
Rationale: Dyschromatosis universalis hereditaria (DUH) is an uncommon form of pigmented genodermatosis that typically inherited autosomally and dominantly. In the previous study, pathogenic genes DUH have been identified in ATP-binding cassette subfamily B, member 6 SASH1 . However, mutational screening causative gene remains incomplete still lacks sufficient proof etiology. Patient concerns: A 2-generation Chinese family clinically diagnosed with were enrolled. They showed spots from their...
Hypoxia is an important characteristic of Tibetan plateau environment. It can lead to apoptosis, but the mechanism apoptosis caused by hypoxic stress needs further clarification. Here, cattle kidney cell MDBK were used as model. The effect on and its molecular explored. cells treated with stress, mitochondrial apoptotic pathway significantly increased, expression B-cell lymphoma 6 (BCL6) was decreased. Overexpressing or inhibiting BCL6 demonstrated that inhibited apoptosis. And increase...
MicroRNAs (miRNAs) serve an important role in the regulation of gene expression. In present study, differential expressions miRNAs were compared between esophageal squamous cell carcinoma (ESCC) tissues and normal tissues. combination with miRNA target prediction databases, a significantly increased expression miR‑612 was discovered ESCC. The relationship TP53 their roles ESCC invasion metastasis further studied by reverse transcription‑quantitative polymerase chain reaction western blotting...
As a continuous work to find more epothilone congeners produced by the epothilones A and B producing Sorangium cellulosum strain So0157-2 in large-scale fermentation (5000 L), we reinvestigated chemical compositions of broth. Consequently, two new variants (1-2) one natural derivative (3) were isolated from Their structures established as 16-ethyl (1), 6-desmethyl-16-hydroxymethyl C (2) 20-ethyl (3), respectively, an extensive NMR analysis.
Although 19p13.13 microdeletion syndrome has been consistently associated with intellectual disability, overgrowth, and macrocephaly, the underlying mechanisms remain unclear. MAST1, a member of microtubule‐associated serine/threonine kinase family, suggested as potential candidate gene responsible for neurologic abnormalities in syndrome, but its role nervous system development remains to be elucidated. Here, we investigated how MAST1 contributes neuronal development. We report that is...