A5033615913- Esophageal Cancer Research and Treatment
- Optimal Power Flow Distribution
- Gastric Cancer Management and Outcomes
- Power System Reliability and Maintenance
- Cancer Immunotherapy and Biomarkers
- Smart Grid Security and Resilience
- Esophageal and GI Pathology
- Smart Grid and Power Systems
- Electric Power System Optimization
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Power System Optimization and Stability
- Smart Grid Energy Management
- Microgrid Control and Optimization
- Head and Neck Cancer Studies
- CAR-T cell therapy research
- Diet and metabolism studies
- Cancer-related Molecular Pathways
- Liver Disease Diagnosis and Treatment
- Complex Network Analysis Techniques
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- HVDC Systems and Fault Protection
- Wireless Signal Modulation Classification
- Metabolomics and Mass Spectrometry Studies
Zhongshan Hospital
2022-2025
The First Affiliated Hospital, Sun Yat-sen University
2023-2025
Fudan University
2022-2025
Sun Yat-sen University
2023-2025
Zhongshan Hospital of Xiamen University
2025
Shanghai Medical College of Fudan University
2023-2024
Tianjin University
2021-2024
Harbin Engineering University
2019
North China Electric Power University
2018
Abstract Overall survival (OS) benefits of neoadjuvant immunotherapy remain elusive in locally advanced esophageal squamous cell carcinomas (ESCC). Here, we reported the results a phase 1b trial PD-L1 blockade with adebrelimab resectable ESCC. Patients received two doses followed by surgery. The primary endpoints were safety and feasibility; secondary included pathologic complete response (pCR) OS. Our data showed feasibility had been met. Common treatment-related adverse events anorexia...
Esophageal cancer (EC) remains highly lethal due to tumor microenvironment (TME)-mediated immune evasion. While natural killer (NK) cells are central antitumor immunity, their functional states in EC poorly characterized. We integrated bulk RNA-seq (TCGA/GEO) and single-cell data construct an NK cell-derived prognostic signature (NK score) via LASSO-Cox regression. Immunofluorescence was applied assess the clinical relevance of SAMD3 + EC. Using both xenograft mouse models vitro co-culture...
Although neoadjuvant chemotherapy and immunotherapy show promise in treating oesophageal squamous cell carcinoma (OSCC), long-term survival data are limited. This randomized, multicenter phase 2 study evaluated the efficacy of perioperative Nivolumab with chemotherapy, followed by surgery adjuvant immunotherapy, patients locally advanced resectable OSCC, explored prognostic role circulating tumor DNA (ctDNA) status. In this trial, participants recruited from five centers were randomly...
Background: Existing models do poorly when it comes to quantifying the risk of Lymph node metastases (LNM). This study aimed develop a machine learning model for LNM in patients with T1 esophageal squamous cell carcinoma (ESCC). Methods and Results: The is multicenter, population based. Elastic net regression (ELR), random forest (RF), extreme gradient boosting (XGB), combined (ensemble) these was generated. contribution each factor calculated. all exhibited potent discriminating power....
Neoadjuvant chemotherapy (nCT) has been the recommended treatment for locally advanced esophageal squamous cell carcinoma (ESCC). The addition of programmed death protein 1 (PD-1) inhibitor to nCT may improve oncologic outcome and survival. However, high-level evidence neoadjuvant immunotherapy (nIT) combined with in resectable ESCC patients are still lacking. Hence, we describe this randomized controlled trial order assess efficacy safety nivolumab combination (stage II-III) patients.This...
Abstract Targeted therapy has fundamentally altered the diagnosis and treatment of clinical cancers. By focusing on chromosomal abnormalities various indications cancer, these medications have paved way for precise malignant tumors. In addition to markedly reversing status quo reliance radiotherapy, chemotherapy, surgery, drugs radically transformed advanced tumors became leading candidates in fight against cancer. Significant advancements new targeted medications, including small molecules...
Objective This study aimed to develop and validate robust predictive models for patients with oesophageal cancer who achieved a pathological complete response (pCR) those did not (non-pCR) after neoadjuvant therapy oesophagectomy. Design Clinicopathological data of 6517 primary underwent oesophagectomy were obtained from the National Cancer Database training cohort. An independent cohort 444 Chinese served as validation set. Two distinct multivariable Cox overall survival (OS) constructed...
Abstract Backgroud Oesophageal cancer ranks among the most prevalent malignant tumours globally, primarily consisting of oesophageal squamous cell carcinoma (ESCC). Cancer stem cells (CSCs) accelerate progression ESCC via their strong self‐renewal and tumourigenic capabilities, presenting significant clinical challenges due to increased risks recurrence drug resistance. Methods Our previous study has reported WYC‐209, which is capable inducing apoptosis CSCs in melanoma hepatoma, but...
Background: Carbon dioxide gas-induced pneumoperitoneum might be the reason for shorter postoperative survival of patients with malignant tumors. Whether CO 2 pneumothorax has unfavorable impacts on surgical and oncological outcomes minimally invasive esophagectomy remains unclear. Methods: Between 2010 2016, a total 998 squamous cell carcinoma esophagus who received video-assisted surgery were registered from three large-volume medical centers. The overall (OS) disease-free (DFS) compared...
Abstract Background Neoadjuvant chemoradiotherapy (nCRT) combined with surgery has been suggested as the standard treatment for locally advanced ESCC. Meanwhile, CHECKMATE-577 that immunotherapy may be effective in controlling tumor recurrence and metastasis. According to PALACE-1, radiotherapy chemotherapy immunity more beneficial patients. Therefore, it is meaningful further study whether combination of nCRT better effects Methods NCT04973306 designed a multicenter, prospective,...
Abstract Background The prognostic significance of lymph nodes with pathological complete treatment response (pcr-LN) has not been well investigated in esophageal squamous cell carcinoma (ESCC). We aimed to determine the impact pcr-LNs ESCC after either neoadjuvant chemoradiotherapy (nCRT) or chemotherapy (nCT). Methods 578 patients from two medical facilities were analyzed retrospectively, 303 receiving nCRT and 275 nCT. Pcr-LNs defined as LNs exhibiting regression changes, such fibrosis,...