A5056063942- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related gene regulation
- Esophageal and GI Pathology
- RNA Interference and Gene Delivery
- Pleural and Pulmonary Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- RNA Research and Splicing
- Medical Imaging and Pathology Studies
- Wnt/β-catenin signaling in development and cancer
- Nanoplatforms for cancer theranostics
- RNA regulation and disease
Ningbo University
2018-2024
Wuxi People's Hospital
2023-2024
Ningbo Medical Center Lihuili Hospital
2013-2024
Nanjing Medical University
2022-2024
Peking University
2023
Jiangsu Province Hospital
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
1999-2023
Fudan University
2023
Academy of Medical Sciences
2023
Shanghai Chest Hospital
2023
MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well established, but the involvement of long noncoding RNAs (lncRNAs) Twist1-mediated signaling remains largely unknown.RT-qPCR western blotting were conducted to detect expression levels lncRNA JPX Twist1 lung lines tissues. The impact on expression, growth, invasion, apoptosis, vivo tumor growth investigated cells by blotting, rescue experiments, colony formation assay, flow...
Circular RNAs (circRNAs) have been demonstrated to contribute esophageal cancer progression. CircBCAR3 (hsa_circ_0007624) is predicted be differentially expressed in by bioinformatics analysis. We investigated the oncogenic roles and biogenesis of circBCAR3 carcinogenesis.Functions on cell proliferation, migration, invasion, ferroptosis were explored using loss-of-function assays. A xenograft mouse model was used reveal effects growth lung metastasis. The upstream downstream mechanisms...
MicroRNAs (MiRNAs) have been found to be dysregulated in lung cancer tissues compared their matched paracancerous tissues. However, the roles of miRNAs peripheral blood as potential biomarkers for early diagnosis remain poorly understood. Here we that miR-33a-5p and miR-128-3p were down-regulated cell lines. The expression levels significantly correlated TNM stages. MiR-128-3p was also remarkably related smoking tumor size. relative positively Notably, whole patients or early-stage (TNM...
Background and aims: The complex process of cancer metastasis remains the least understood. Tumor cells alter their protein expression profile to survive from tumor metastasis. Fibronectin 1 (FN1 gene coding protein) is a member glycoprotein family that has been shown play an important role in However, its effects on melanoma are still unclear. Methods: We detected FN1 between metastatic primary by using Western blot RT-qPCR assays. And, we analyzed expressed feature different tissues...
Abstract Circulation tumor cells (CTCs) in the bloodstream of early-stage cancer patients carry important information about valuable biomarkers and biological properties primary tumor. However, detection capture CTCs are challenging owing to their low concentrations. Traditional technologies have limited sensitivity efficiency. We, herein, report an effective approach specifically bind colon HT29 by using multiple Sialyl Lewis X antibodies (aSlex)-conjugated PAMAM dendrimers. The conjugation...
Specifically capturing and restraining residual circulating tumor cells (CTCs) in cancer patients are the sine qua non for safely effectively preventing metastasis, to which current chemotherapy has been limited due its toxicity. Moreover, because of CTCs’ rarity low activity, technology CTCs based solely on a single surface biomarker capacity is used mainly vitro diagnosis. Here, it possible sequentially conjugate two antibodies (aEpCAM aSlex) functionalized dendrimers specifically capture...
Although tumor-derived exosomes play an important role in the process of metastasis, differences secreted by same cells at different stages or conditions have not been noticed most relevant researchers.Here we developed a lung cancer model nude mice, and phenotype inclusions early advanced tumors were analysed.The size distribution surface topography these two significantly different, but expression CD63 tumor exosome (E-exosome) was lower than that (A-exosome).α-SMA on HELF treated with...
Objective This study aims to develop a predictive model for identifying lung cancer patients at elevated risk bone metastases, utilizing the Unified Immunoinflammatory Index and various tumor markers. is expected facilitate timely effective therapeutic interventions, especially in context of growing significance immunotherapy treatment. Methods A retrospective analysis was conducted on 324 treated between January 2019 2021. After meeting inclusion criteria, 241 were selected, with 56...
The effective treatment of acute lung injury (ALI) remains a significant challenge. Patients with ALI demonstrate an abundance proinflammatory mediators in both bronchoalveolar lavage fluid (BALF) and circulating plasma. Bardoxolone methyl (BM) is semi-synthetic triterpenoid derived from oleanolic acid, natural product known for its ability to inhibit signaling. GSDMD signaling protein involved pyroptosis, form programmed cell death. It has been reported that upstream proteins play role the...
Background Studies on the prognostic factors for patients with brain oligo-metastasis treated fractionated stereotactic radiotherapy (FSRT) usually focus size of metastatic tumor and radiation dose. Some inflammatory indicators have predictive value in non-small cell lung cancer (NSCLC) metastasis receiving radiotherapy. However, NSCLC FSRT, their effect dose is unknown. Methods A total 95 advanced who had undergone FSRT treatment at Ningbo Medical Center Lihuili Hospital between January...
Endoscopic therapies for T1 esophageal carcinoma have been increasingly used around the world. However, procedures are limited by without lymph nodes harvested. The risk of node metastasis (LNM) should established. Our objective was to construct a nomogram model predict risks LNM in patients with pT1 squamous cell (ESCC).We reviewed records 221 ESCC who underwent surgical resection and radical lymphadenectomy. Clinicopathological variables were analyzed univariate multivariate logistic...
Background: Circular RNAs (circRNAs) are crucial regulators in human cancers, including non-small cell lung cancer (NSCLC). In this study, we explore the biological functions and molecular mechanisms of circ_0074027 NSCLC. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to determine expression circ_0074027, paired like homeodomain 1 (PITX1) mRNA, microRNA-335-5p (miR-335-5p), cullin 4B (CUL4B) mRNA. The features were analyzed by RNase R digestion assay. Flow...
Esophageal squamous cell carcinoma (ESCC) has become a major health risk to human health. Although significant clinical progress been made in the treatment of ESCC, prognosis patients still needs be improved. Therefore, it is important screen effective molecular indicators for ESCC. In this study, intersection up-regulated genes, down-regulated and Wnt signaling pathway-related genes ESCC was taken, 47 overlapping were found. PRICKLE1 determined an independent prognostic factor based on...