A5101808027- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Multimodal Machine Learning Applications
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Biosensors and Analytical Detection
- Photodynamic Therapy Research Studies
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Advanced Image and Video Retrieval Techniques
- Intraperitoneal and Appendiceal Malignancies
- Ferroptosis and cancer prognosis
- Dendrimers and Hyperbranched Polymers
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Radiomics and Machine Learning in Medical Imaging
Nanjing Tech University
2025
Guangdong Province Women and Children Hospital
2025
Northwest Normal University
2025
Shandong First Medical University
2021-2024
Anhui Polytechnic University
2024
University of California, Davis
2022-2024
Xiamen University
2017-2024
Shandong Tumor Hospital
2021-2024
Nanfang Hospital
2018-2020
Southern Medical University
2018-2020
Purpose: Current tumor-node-metastasis (TNM) staging system cannot provide adequate information for prediction of prognosis and chemotherapeutic benefits. We constructed a classifier to predict identify subset patients who can benefit from adjuvant chemotherapy.Experimental Design: detected expression 15 immunohistochemistry (IHC) features in tumors 251 gastric cancer (GC) evaluated the association their level with overall survival (OS) disease-free (DFS). Then, integrating multiple...
Current gastric cancer staging alone cannot predict prognosis and adjuvant chemotherapy benefits in stage II III cancer. Tumor immune microenvironment biomarkers tumor-cell chemosensitivity might add predictive value to staging. This study aimed construct a signature integrating tumor chemosensitivity-related features improve the prediction of survival patients with We used IHC assess 26 related tumor, stroma, tumors from 223 evaluated association disease-free (DFS) overall (OS). Support...
Adhesion of circulating tumor cells (CTCs) to vascular endothelial bed becomes a crucial starting point in metastatic cascade. We hypothesized that nitric oxide (NO) may prevent cancer metastasis from happening by its direct vasodilation and inhibition cell adhesion molecules (CAMs). Here we show S-nitrosocaptopril (CAP-NO, typical NO donor) produced vasorelaxation can be antagonized scavenger hemoglobin guanylate cyclase inhibitor. Cytokines significantly stimulated production CAMs the...
BACKGROUND This study was aimed at establishing a sensitive and specific isolation, characterization, enumeration method for living circulating tumor cells (CTCs) in patients with colorectal carcinoma. METHODS Quantitative isolation characterization of CTCs were performed through combination immunomagnetic negative enrichment fluorescence‐activated cell sorting. Isolated identified by immunofluorescence staining. The viability purity the sorted determined flow cytometry. Blood samples spiked...
Abstract Circulation tumor cells (CTCs) in the bloodstream of early-stage cancer patients carry important information about valuable biomarkers and biological properties primary tumor. However, detection capture CTCs are challenging owing to their low concentrations. Traditional technologies have limited sensitivity efficiency. We, herein, report an effective approach specifically bind colon HT29 by using multiple Sialyl Lewis X antibodies (aSlex)-conjugated PAMAM dendrimers. The conjugation...
// Liyuan Wan 1,* , Haiyan Dong Huo Xu 1 Ji Ma Yewei Zhu Yusheng Lu Jichuang Wang Ting Zhang Tao Li Jingjing Xie Bo 2 Fangwei 3 Yu Gao Jingwei Shao Xiaohuang Tu 4 and Lee Jia Cancer Metastasis Alert Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory on Energy Environment, College Chemistry, Fuzhou University, Fuzhou, China Obstetrics Gynecology, General Hospital, Department Medicine Oncology, East Hospital Xiamen Surgery, * These authors have contributed equally to this...
Specifically capturing and restraining residual circulating tumor cells (CTCs) in cancer patients are the sine qua non for safely effectively preventing metastasis, to which current chemotherapy has been limited due its toxicity. Moreover, because of CTCs’ rarity low activity, technology CTCs based solely on a single surface biomarker capacity is used mainly vitro diagnosis. Here, it possible sequentially conjugate two antibodies (aEpCAM aSlex) functionalized dendrimers specifically capture...
Dissemination of circulating tumor cells (CTCs) in blood and their hetero-adhesion to vascular endothelial bed distant metastatic secondary organs are the critical steps initiate cancer metastasis.The rarity CTCs made vivo capture technically challenging.Current techniques by virtue nanostructured scaffolds monovalently conjugated with a single antibody and/or drug seem less efficient specific capturing CTCs.Here, we report novel platform developed re-engineer nanoscale dendrimers for...
Background Gestational diabetes mellitus (GDM) patients are one of the important high-risk groups for development pre-eclampsia (PE). The pathogenesis PE in GDM is not fully understood. This study aims to identify hub genes and pathways associated with co-occurrence PE.
Despite the efficiency of prompt learning in transferring vision-language models (VLMs) to downstream tasks, existing methods mainly learn prompts a coarse-grained manner where learned vectors are shared across all categories. Consequently, tailored often fail discern class-specific visual concepts, thereby hindering transferred performance for classes that share similar or complex attributes. Recent advances mitigate this challenge by leveraging external knowledge from Large Language Models...
We constructed a gold-spiked nanosphere nanozyme-based paper platform for non-invasive detection of glucose.
Cancer metastatic spread is life-threatening and caused by circulating tumor cells (CTCs) that are very difficult to precisely capture in vivo. Here we show two aptamer rings targeting different CTC biomarker epitopes conjugated on dendrimers CTCs with enhanced precision even the presence of 108 interfering cells, or blood mice patient samples when compared their single counterparts. The aptamer-conjugate inhibited vivo metastasis demonstrated biostability resisting biodegradation endogenous...
Population-based estimates for prognosis among patients with liver metastases in newly diagnosed breast cancer are not generally available.Within the Surveillance, Epidemiology and End Results (SEER) database, we identified 298,370 4,285 initial between 2010 2014. Data were stratified according to subtype, age, race. Multivariate logistic Cox regression used identify predictors presence of prognostic factors, respectively. Kaplan-Meier procedure was survival analysis.A total (1.4% entire...
Objective: The aim of this study is to evaluate whether radiomic imaging signatures based on computed tomography (CT) could predict peritoneal metastasis (PM) in gastric cancer (GC) and develop a nomogram for preoperative prediction PM status. Methods: We collected CT images pathological T4 955 consecutive patients two centers analyzing the radiomics features retrospectively then developed validated model built from 292 quantitative image training cohort validation cohorts. Lasso regression...