A5101623349- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Plant Virus Research Studies
- Genetic Mapping and Diversity in Plants and Animals
- Viral Infectious Diseases and Gene Expression in Insects
- Genomic variations and chromosomal abnormalities
- RNA Interference and Gene Delivery
- Autism Spectrum Disorder Research
- Hepatitis Viruses Studies and Epidemiology
- Soil Carbon and Nitrogen Dynamics
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Herpesvirus Infections and Treatments
- Genetic and phenotypic traits in livestock
- HIV Research and Treatment
- RNA and protein synthesis mechanisms
- Peatlands and Wetlands Ecology
Jilin Engineering Normal University
2024
Chinese Academy of Sciences
2023-2024
ZheJiang Academy of Agricultural Sciences
2012-2024
Hefei Institutes of Physical Science
2023-2024
University of Science and Technology of China
2023-2024
Iowa State University
2022-2023
University of Wisconsin–Madison
2019-2021
East China Normal University
2020
Animal Science Research Institute
2012-2019
Cornell University
2010
ABSTRACT RNA interference (RNAi) is a powerful tool to silence gene expression posttranscriptionally. In this study, we evaluated the antiviral potential of small interfering (siRNA) targeting VP1 foot-and-mouth disease virus (FMDV), which essential during life cycle and plays key role in attachment susceptible cells. We investigated vivo inhibitory effect VP1-specific siRNAs on FMDV replication BHK-21 cells suckling mice, commonly used animal model. The results showed that transfection...
Duck tembusu virus (DTMUV) is an emerging agent that causes a severe disease in ducks. We report herein the first complete genome sequences of duck strains YY5, ZJ-407, and GH-2, isolated from Shaoxing ducks, breeder geese, respectively, China. The genomes GH-2 are all 10,990 nucleotides (nt) length encode putative polyprotein 3,426 amino acids. It flanked by 5' 3' noncoding region (NCR) 94 618 nt, respectively. Knowledge whole sequence DTMUV will be useful for further studies mechanisms...
Driven by the good developmental potential and favorable environment at this stage, Ganoderma lucidum is recognized as a precious large fungus with medicinal nutritional health care values. Among them, polysaccharides, triterpenoids, oligosaccharides, trace elements, etc. are important bioactive components in G. . These will have an impact on gut flora, thus alleviating diseases such hyperglycemia, hyperlipidemia obesity caused flora disorder. While numerous studies demonstrated ability of...
ABSTRACT We report the full-genome sequence of a goose-origin reovirus (GRV) strain 03G from Zhejiang Province, China. This is first complete genomic (segments 1 to 10) GRV. Phylogenetic analyses suggest that GRV represents new species distinct other established within avian (ARV) group orthoreoviruses.
ABSTRACT We report the first full-length infectious clone of strain JX/CHA/97 rabbit hemorrhagic disease virus (RHDV). The transcripts from cDNA clones were when they directly injected into rabbits. sequence recovered rabbits was identical to that RNA transcripts. engineered contain one silent nucleotide change create an EcoRV site (A T at 2908). genetic marker retained in progeny virus. transfection RK-13 cells resulted synthesis viral antigens, indicating replication competent. This stable...
Fusarium asiaticum belongs to one of the phylogenetical subgroups F. graminearum species complex and is epidemically predominant in East Asia area. The life cycle significantly regulated by light. In this study, fungal blue light receptor white collar (WCC), including FaWC1 FaWC2, were characterized asiaticum. knockout mutants ΔFawc1 ΔFawc2 generated replacing target genes via homologous recombination events. two showed similar defects light-induced carotenoid biosynthesis, UV-C resistance,...
Rabbit hemorrhagic disease virus (RHDV), a member of the family Caliciviridae comprising positive-stranded RNA viruses, is highly virulent pathogen rabbits. Until recently, studies into molecular mechanisms RHDV replication and pathogenesis have been hindered by lack an in vitro culture system reverse genetics. This study describes generation DNA-based genetics for subsequent investigation biological role VP2 protein. The full-length genome was assembled as single cDNA clone placed under...
Recent advances in consortium-scale genome-wide association studies (GWAS) have highlighted the involvement of common genetic variants autism spectrum disorder (ASD), but our understanding their etiologic roles, especially interplay with rare variants, is incomplete. In this work, we introduce an analytical framework to quantify transmission disequilibrium genetically regulated gene expression from parents offspring. We applied conduct a transcriptome-wide study (TWAS) on 7,805 ASD...
Abstract Background Duck enteritis virus (DEV) is the causative agent of duck viral enteritis, which causes an acute, contagious and lethal disease many species waterfowl within order Anseriformes . In recent years, two laboratories have reported on successful construction DEV infectious clones in vectors to express exogenous genes. The obtained were either created with deletion genes based highly virulent strains or constructed using a traditional overlapping fosmid DNA system. Here, we...
Duck reovirus (DRV) is an typical aquatic bird pathogen belonging to the Orthoreovirus genus of Reoviridae family. Reovirus causes huge economic losses duck industry. Although DRV has been identified and isolated long ago, responses Cairna moschata classical/novel (CDRV/NDRV) infections are largely unknown. To investigate relationship pathogenesis immune response, proteomes C. liver cells under C/NDRV were analyzed, respectively. In total, 5571 proteins identified, among which 5015...
Rabbit hemorrhagic disease virus (RHDV) has two structural proteins: the major capsid protein VP60 and minor VP2. VP2 is speculated to play an important role in life cycle. To investigate effect of on expression, three types experiment (baculovirus-insect cell system, mammalian-luciferase assay system vitro coupled transcription/translation system) were used express alone or co-expressed with Both forms able form virus-like particles insect cells. Western blot analysis dual-luciferase assays...