A5100331035- Endoplasmic Reticulum Stress and Disease
- Pregnancy and preeclampsia studies
- Aldose Reductase and Taurine
- RNA modifications and cancer
- Signaling Pathways in Disease
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Birth, Development, and Health
- Circular RNAs in diseases
- RNA Research and Splicing
- Cassava research and cyanide
- Marine Bivalve and Aquaculture Studies
- RNA Interference and Gene Delivery
- Total Knee Arthroplasty Outcomes
- Autophagy in Disease and Therapy
- Genomics, phytochemicals, and oxidative stress
- RNA regulation and disease
- PARP inhibition in cancer therapy
- Calcium signaling and nucleotide metabolism
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Ginseng Biological Effects and Applications
- Aquaculture Nutrition and Growth
- Orthopaedic implants and arthroplasty
First Affiliated Hospital of Bengbu Medical College
2022-2025
Dalian Ocean University
2024-2025
Anhui University of Finance and Economics
2025
Nanjing General Hospital of Nanjing Military Command
2024
Nanjing University
2024
SUNY Upstate Medical University
2023
Binzhou Medical University
2023
Binzhou University
2023
Henan Agricultural University
2023
Xuzhou Medical College
2020-2023
The construction of the Disease Ontology (DO) has helped promote investigation diseases and disease risk factors. DO enables researchers to analyse similarity by adopting semantic measures, expanded our understanding relationships between different classify them. Simultaneously, similarities genes can also be analysed their associations with similar diseases. As a result, heterogeneity is better understood insights into molecular pathogenesis have been gained. However, bioinformatics tools...
Background: Histone lactylation, a novel epigenetic modification induced by hypoxia and lactate, plays an important role in regulating gene expression. However, the of histone lactylation pathogenesis preeclampsia remains unknown. Methods: Placentas from preeclamptic patients control pregnant women were collected for protein immunoassay to detect expression level two trophoblast cell lines used simulate effect on genes. Results: We found that lactate levels increased placentas. In vitro, was...
Abstract Background The accumulation of reactive oxygen species (ROS) resulting from upregulated levels oxidative stress is commonly implicated in preeclampsia (PE). Ferroptosis a novel form iron-dependent cell death instigated by lipid peroxidation that likely plays an important role PE pathogenesis. This study aimed to investigate the expression profiles and functions ferroptosis-related genes (FRGs) early-onset (EOPE) late-onset (LOPE). Methods Gene data clinical information were...
Recent studies demonstrate that rapid translocation of the acid sphingomyelinase (ASM), a lysosomal hydrolase, to outer leaflet cell membrane and concomitant release ceramide constitute common cellular signaling cascade various stimuli including CD95 ligation, UV-irradiation, bacterial viral infections. Reactive oxygen species (ROS) were shown play crucial role in regulating this at least for some infections UV-irradiation. However, precise ROS regulation ASM is unknown. Here, by confocal...
To evaluate precise assessment methods for predicting the optimal acetabular cup size in total hip arthroplasty (THA). A clinical data of 73 patients (80 hips) who underwent primary THA between December 2022 and July 2024 met inclusion criteria was analyzed. There were 39 males 34 females with an average age 66.3 years (range, 56-78 years). Among them, 66 cases unilateral 7 bilateral THAs. 29 (34 osteoarthritis, 35 (35 femoral neck fractures, 9 (11 osteonecrosis head. Based on...
Na(V)1.5 is a cardiac voltage-gated Na(+) channel αsubunit and encoded by the SCN5a gene. The activity of this determines depolarization electrical conduction. Channel defects, including mutations decrease protein levels, have been linked to development arrhythmias. molecular mechanisms underlying regulation expression are largely unknown. Forkhead box O (Foxo) proteins transcriptional factors that bind consensus DNA sequences in their target gene promoters regulate these genes. Comparative...
Abstract Glioma is the most common primary malignant brain tumor in adults and remains an incurable disease at present. Thus, there urgent need for progress finding novel molecular mechanisms that control progression of glioma which could be used as therapeutic targets patients. The RNA binding protein cytoplasmic polyadenylate element-binding 2 (CPEB2) involved pathogenesis several tumors. However, role CPEB2 unknown. In this study, functional characterization mechanism were examined using...
The activation of NF-κB has emerged as an important mechanism for the modulation response to DNA double-strand breaks (DSBs). concomitant SUMOylation and phosphorylation IKKγ by PIASy ATM, respectively, is a key event in this mechanism. However, through which mammalian cells are able accomplish these modifications timely lesion-specific manner remains unclear. In study, we demonstrate that LRP16 constitutively interacts with PARP1 IKKγ. This interaction essential efficient interactions among...
Background: Early-onset preeclampsia (EOPE) is a serious pregnancy disorder with multisystem complications. Recently, circRNA was reported to participate in the progression of EOPE. However, role and mechanism circRNA_06354 pathophysiological development EOPE remain unclear. Methods: Blood samples from patients healthy pregnant controls (CTRL) were analyzed by RNA-seq. functions mechanisms investigated series experiments. An rat model constructed detect expression levels circRNA_06354....
Leukemia stem cells (LSC) require frequent adaptation to maintain their self-renewal ability in the face of longer exposure cell-intrinsic and cell-extrinsic stresses. However, mechanisms by which LSC leukemogenic activities, how individual respond stress, remain poorly understood. Here, we found that DNAJC10, a member HSP40 family, was frequently up-regulated various types acute myeloid leukemia (AML) LSC-enriched cells. Deficiency DNAJC10 leads dramatic increase apoptosis both human cell...
Summary We detected that Fas receptor (Fas) was expressed at transcriptional levels in oocytes/eggs and some granulosa cells of murine ovary, whereas, ligand (FasL) found to be strongly by means situ hybridisation. These results were supported an indirect immunofluorescence (IIF) test with anti-Fas monoclonal antibody (mAb)/FasL Ab. The lysates from precipitated anti-FasL Ab, exhibiting a specific band 40 kDa. When zona pellucida (ZP)-free eggs incubated vitro , apoptosis (DNA fragmentation)...