A5075764384- Asymmetric Hydrogenation and Catalysis
- Geomechanics and Mining Engineering
- Iron Metabolism and Disorders
- Chemical Synthesis and Analysis
- Rock Mechanics and Modeling
- Geoscience and Mining Technology
- Pregnancy and preeclampsia studies
- Trace Elements in Health
- Climate change and permafrost
- Organoboron and organosilicon chemistry
- Thermal Radiation and Cooling Technologies
- Coal Properties and Utilization
- Advanced Battery Materials and Technologies
- Drug Transport and Resistance Mechanisms
- Asymmetric Synthesis and Catalysis
- Hemoglobinopathies and Related Disorders
- MicroRNA in disease regulation
- Advancements in Battery Materials
- Organophosphorus compounds synthesis
- Solar-Powered Water Purification Methods
- Catalytic C–H Functionalization Methods
- Solar Thermal and Photovoltaic Systems
- Cryospheric studies and observations
- Erythropoietin and Anemia Treatment
- Catalytic Alkyne Reactions
First Affiliated Hospital of Bengbu Medical College
2025
Chinese Academy of Sciences
2008-2024
University of Chinese Academy of Sciences
2022-2024
State Grid Corporation of China (China)
2024
Research Center for Eco-Environmental Sciences
2022-2024
Heilongjiang Electric Power Workers University
2024
University of Science and Technology of China
2021-2023
Institute of Genetics and Developmental Biology
2023
Suzhou Institute of Nano-tech and Nano-bionics
2022
Qingdao Institute of Bioenergy and Bioprocess Technology
2022
Restricted ambient temperature and slow heat replenishment in the phase transition of water molecules severely limit performance evaporation-induced hydrovoltaic generators. Here we demonstrate a conduction effect enhanced power generator by integrating flexible ionic thermoelectric gelatin material with porous dual-size Al
The practical synthesis of P-stereogenic tertiary phosphines, which have wide applications in asymmetric catalysis, materials, and pharmaceutical chemistry, represents a significant challenge. A regio- enantioselective hydrophosphination using cheap ubiquitous alkynes catalyzed by nickel complex was designed, the toxic air-sensitive secondary phosphines were prepared situ from bench-stable phosphine oxides. This methodology has been demonstrated with unprecedented substrate scope functional...
The catalytic asymmetric synthesis of
A mechanism-inspired, reaction mode-controlled enantio- and regioselective anti-Markovnikov hydrophosphination of unactivated alkynes was accomplished by NiII catalysis. Alkenyl phosphine products could be obtained with high regio- enantioselectivity easily derivatized to structurally diverse chiral compounds. Mechanistic studies on both Ni0-catalyzed Markovnikov addition NiII-catalyzed have been carried out combining experimental computational methods. In the Ni0 system, an allyl nickel...
The asymmetric synthesis of P-stereogenic phosphinates through allylic alkylation H-phosphinates has been developed. With and acetates as the starting materials, a variety P-chiral were accessed in high enantioselectivities up to 92% ee generally yields. In addition, further study demonstrated applicability this protocol, including scale-up facile transformation chiral products from phosphine oxides with organolithium reagents under mild reaction conditions.
Background: Histone lactylation, a novel epigenetic modification induced by hypoxia and lactate, plays an important role in regulating gene expression. However, the of histone lactylation pathogenesis preeclampsia remains unknown. Methods: Placentas from preeclamptic patients control pregnant women were collected for protein immunoassay to detect expression level two trophoblast cell lines used simulate effect on genes. Results: We found that lactate levels increased placentas. In vitro, was...
Abstract The development of solid‐state electrolytes with high ionic conductivity, broad electrochemical stability, and air stability is the key to realizing practical application all‐solid‐state batteries. Herein, Sb‐ O‐cosubstituted Li 10 SnP 2 S 12 sulfide are prepared for first time. An appropriate amount Sb O substitution provides optimized 1.84 0.16 11.6 0.4 electrolyte highest conductivity 2.58 mS ⋅ cm −1 at RT. Furthermore, cyclic voltammetry analysis results demonstrate that...
Current iron overload therapeutics have inherent drawbacks including perpetuated low hepcidin. Here, we unveiled that lactate, a potent hepcidin agonist, effectively reduced serum and hepatic levels in mouse models of with an improved erythropoiesis β-thalassemic mice.
Chiral ionic liquids (CILs) are widely used solvents and materials with prominent properties. Carbohydrate-derived imidazolium-based CILs represent a distinctive type of possessing multiple chiral centers from natural pool. Herein, series glucopyranoside-substituted (Glu-imi-CILs) were synthesized evaluated as ligands for Pd-catalyzed homo-coupling reactions arylboronic acids in water. The glucopyranoside substituent was instrumental improving the catalytic activity resulting catalysts....
A mathematical models for the coupled problem is established by considering heat and mass transfer phase change rock at low temperature, according to theory of porous media. It considered influences fluid on conduction temperature gradient seepage. By adopting finite element method, numerical simulation done study range frost-thaw surrounding effects insulation material in cold regions, which analysis influence tunnel depth class frost-thaw, law area different relationship between thickness material.
Increasing evidence reveals that iron deficiency during pregnancy causes adverse outcomes. Thus far, the mechanisms underlying deficiency-associated preterm birth are mostly limited to animal studies. Whether suggested exist in human requires further investigation. The goal of this study was characterize metabolism both maternal side and fetal pregnant women with birth. Serum placenta samples were collected from 42 divided into four groups according gestational week. Indicators metabolism,...
Abstract Addition reaction to alkynes is an efficient strategy for constructing valuable alkenyl compounds. However, the elusive regioselectivity has been a persistent challenge. In context of hydrophosphination which could afford P-stereogenic phosphines, control enantioselectivity as well were especially tricky. Here, we highlighted our recent work on nickel-catalyzed regio- and enantioselective unactivated with in situ generated secondary phosphines. 1 Introduction 2 Hydrophosphination...
The interaction between the structure and soil is key factor for infrastructure stabilization in permafrost engineering. In this study, shear mechanical behavior of interface concrete under different normal stiffness, temperature water content investigated by using direct test temperature-controlled conditions. results show that with increase content, initial stiffness stress-shear displacement curve gradually increases, strength increases. Different stiffnesses have a small effect on...
Abstract Background and Aims Disorders in liver lipid metabolism have been implicated a range of metabolic conditions, including fatty cancer. Altered distribution within the liver, shifting from pericentral to periportal zone under pathological circumstances, has observed; however, underlying mechanism remains elusive. Iron, an essential metal, exhibits zonal similar that lipids. Nevertheless, precise relationship between iron distribution, especially zones, poorly understood. Methods We...
Considering the influence of phase change and temperature variation on physical mechanical properties low-temperature rock in cold regions, mathematical model for Thermo-Hydro(TH) coupled problem is proposed based theory convective heat transfer porous medium. In this model, moisture migration conduction taken into account, as well gradient seepage. The involved parameters are determined according to related equations given paper. Then finite element a gas transmission pipeline region...
The Cover Feature shows an all-solid-state battery based on Sb, O cosubstituted high-performance sulfide electrolyte with stored energy from renewable such as wind and solar to drive rail transit. More information can be found in the Research Article by J. Gao et al.
Abstract Background Copper is an essential but also toxic heavy metal. As a crucial micronutrient, copper required for various enzymes in physiology and pathology. Meanwhile, overload has currently raised serious public health concerns. can perturb intracellular homeostasis induce oxidative stress even cell death. More recently, cuproptosis been identified as copper-dependent form of death induced by mitochondria. This mitochondrial characterized lipoylated protein aggregation loss...
Based on the developed low permeability test instrument, gas transport properties of typical Jin-Ping marbles are studied under steady flow nitrogen. A instrument and its tri-axial cell structure were introduced in detail, this was used to study dense rocks different temperatures stress conditions, Test results showed that intrinsic marble is about 10－20 m2. Comparisons made between an exact method which considers Klinkenberg effect equation. Fitting using show better agreement with...