A5078599028- Advanced Photocatalysis Techniques
- Advanced Sensor and Energy Harvesting Materials
- Pancreatic function and diabetes
- Metal-Organic Frameworks: Synthesis and Applications
- Neuroscience and Neural Engineering
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Conducting polymers and applications
- Advanced Memory and Neural Computing
- Covalent Organic Framework Applications
- Nanomaterials for catalytic reactions
- Photonic Crystal and Fiber Optics
- Erythrocyte Function and Pathophysiology
- Metabolism, Diabetes, and Cancer
- Ammonia Synthesis and Nitrogen Reduction
- Advanced Fiber Laser Technologies
- Photoreceptor and optogenetics research
- Hydrogen Storage and Materials
- Supercapacitor Materials and Fabrication
- Advanced Fiber Optic Sensors
- Semiconductor Lasers and Optical Devices
- Solar-Powered Water Purification Methods
- Muscle activation and electromyography studies
- Thermal Radiation and Cooling Technologies
- Cholesterol and Lipid Metabolism
Ningbo Medical Center Lihuili Hospital
2022-2025
Ningbo University
2022-2025
Suzhou Institute of Nano-tech and Nano-bionics
2018-2025
Chinese Academy of Sciences
2011-2025
Guangdong University of Technology
2017-2024
Henan Normal University
2024
University of Chinese Academy of Sciences
2011-2024
Research Center for Eco-Environmental Sciences
2023-2024
Beijing Institute of Fashion Technology
2024
Weill Cornell Medicine
2019-2023
Type 2 diabetes is often accompanied by abnormal blood lipid and lipoprotein levels, but most studies on the link between hyperlipidemia have focused free fatty acids (FFAs). In this study, we examined relationship cholesterol insulin secretion from pancreatic beta-cells that independent of effects FFAs.Several methods were used to modulate levels in intact islets cultured beta-cells, including a recently developed mouse model exhibits elevated normal FFA levels. Acute metabolic alteration...
Plasma membrane phosphatidylinositol (PI) 4-phosphate (PtdIns4P) has critical functions via both direct interactions and metabolic conversion to PI 4,5-bisphosphate (PtdIns(4,5)P2) other downstream metabolites. However, mechanisms that control this PtdIns4P pool in cells of higher eukaryotes remain elusive. PI4KIIIα, the enzyme thought synthesize pool, is reported localize ER, contrary plasma localization its yeast homologue, Stt4. In paper, we show PI4KIIIα was targeted as part an...
Restricted ambient temperature and slow heat replenishment in the phase transition of water molecules severely limit performance evaporation-induced hydrovoltaic generators. Here we demonstrate a conduction effect enhanced power generator by integrating flexible ionic thermoelectric gelatin material with porous dual-size Al
Abstract Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for treatment under the stimulation of light/ultrasound, which have characteristics broad‐spectrum properties, low drug‐resistance, effective targeting infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers sensitizers. They enhance stability permeability...
We examined the intracellular transport of sterol in living cells using a naturally fluorescent cholesterol analog, dehydroergosterol (DHE), which has been shown to mimic many properties cholesterol. By DHE loaded on methyl-β-cyclodextrin, we followed this analog pulse-chase studies. At steady state, co-localizes extensively with transferrin (Tf), marker for endocytic recycling compartment (ERC), and redistributes Tf altered ERC morphology. Expression dominant-negative mutation an...
Local inhomogeneities in lipid composition play a crucial role regulation of signal transduction and membrane traffic. Nevertheless, most evidence for microdomains cells remains indirect, the nature has been difficult to characterize. We used analogs lipid-anchored proteins with varying fluidity preferences examine effect modulating cellular cholesterol on domain formation. show that lowering levels induces formation visible micrometer-scale domains plasma several mammalian cell types...
Lipids and other membrane constituents recycle between the plasma intracellular endocytic compartments. In CHO cells, approximately half of internalized C<sub>6</sub>-NBD-SM, a fluorescent lipid analogue widely used as maker, recycles via recycling compartment with <i>t</i> <mml:math><mml:mrow><mml:mn>1</mml:mn></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:math> ∼12 min (Mayor, S., Presley, J. F., Maxfield, F. R. (1993) <i>J. Cell Biol.</i> 121, 1257–1269). Surprisingly, rest...
The growing worldwide obesity epidemic is frequently linked to an increased risk of developing diseases such as diabetes, cardiovascular disease, and cancer. These are associated with the infiltration macrophages in white adipose tissue (WAT), artery wall, tumors, respectively; these likely contribute disease progression pathogenesis. Abdominal WAT, surrounding heart well carcinoma cells, secrete many factors that could induce macrophage infiltration. Leptin adipocyte-secreted hormone,...
Abstract Fast progress in material science has led to the development of flexible and stretchable wearable sensing electronics. However, mechanical mismatches between devices soft human tissue usually impact performance. An effective way solve this problem is develop mechanically superelastic compatible sensors that have high sensitivity whole workable strain range. Here, a buckled sheath–core fiber‐based ultrastretchable sensor with enormous stain gauge enhancement reported. Owing its...
Flexible self-powered multifunctional sensing systems provide a promising direction for the development of wearable electronics. Although increased efforts have been devoted to developing integrated devices, flexible and adaptable with miniaturized stable power supplies is highly desirable yet greatly challenging. Herein, an ambient moisture-induced system was fabricated by integrating porous polydopamine layer hydroxy group gradient (called g-PDA) based moisture-enabled generator pressure...
Abstract A 2D boron nanosheet that exhibits high theoretical capacitance, around four times of graphene, is a significant supercapacitor electrode. However, its bulk structure with low interlaminar conduction and porosity restricts the charge transfer, ion diffusion, energy density. Herein, we develop new hetero‐nanosheet made anisotropic boron–carbon nanosheets (ABCNs) by B−C chemical bonds via gas‐phase exfoliation condensation bottom‐up strategy. The ABCNs are constructed into flexible...
Articular cartilage, which exhibits toughness and ultralow friction even under high squeezing pressures, plays an important role in the daily movement of joints. However, joint soft tissue lesions or injuries caused by diseases, trauma, human functional decline are inevitable. Poly(vinyl alcohol) (PVA) hydrogels, have a water content compressive strength similar to those many tissues organs, potential replace tough connective tissues, including cartilage. currently, PVA hydrogels not...
Abstract The neural signals produced by varying electrical stimulation parameters lead to characteristic circuit responses. However, the characteristics of circuits reconstructed remain poorly understood, which greatly limits application such neuromodulation techniques for treatment spinal cord injury. Here, we develop a dual system that combines epidural and muscle mimic feedforward feedback in sensorimotor circuits. We demonstrate stimulus frequency 10−20 Hz under conditions is required...
Liver X receptor/retinoid receptor (LXR/RXR) transcription factors have been found to induce a number of genes involved in the regulation cellular cholesterol efflux, including ATP-binding cassette transporter A1 (ABCA1), which mediates active efflux and phospholipids extracellular acceptors, such as apolipoprotein A-I (apoA-I). In screen for macrophage LXR/RXR target genes, we identified stearoyl-CoA desaturases 1 2 (Scd1 Scd2), subsequently tested hypothesis that SCD activity might...
The formation of mature secretory granules is essential for proper storage and regulated release hormones neuropeptides. In pancreatic β cells, cholesterol accumulation causes defects in insulin secretion may participate the pathogenesis type 2 diabetes. Using a novel analog, we show first time that are major sites intracellular live cells. This distinct from other, non-secretory cell types, which concentrated recycling endosomes trans-Golgi network. Excess was delivered specifically to...
Abstract A prominent challenge for artificial synaptic devices toward perception systems is hardware redundancy, which demands neuromorphic that integrate both sensing and processing functions. Inspired by the biological visual nervous systems, a novel flexible, dual‐modulation field‐effect transistor (SFET) demonstrated in this work. The flexible SFET constructed with zinc oxide nanowires sodium alginate, acts as semiconductor layer gate dielectric, respectively. An excitatory postsynaptic...