A5100726391- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Aquaculture Nutrition and Growth
- Cancer-related gene regulation
- Plant Virus Research Studies
- MicroRNA in disease regulation
- Aquaculture disease management and microbiota
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Aquatic life and conservation
- Plant tissue culture and regeneration
- Transgenic Plants and Applications
- Anesthesia and Pain Management
- HER2/EGFR in Cancer Research
- Plant-Microbe Interactions and Immunity
- Circular RNAs in diseases
- Multiferroics and related materials
- Plant Molecular Biology Research
- Advanced Condensed Matter Physics
- Toxin Mechanisms and Immunotoxins
- Insect-Plant Interactions and Control
Centre National de la Recherche Scientifique
2022-2025
Université Paris Cité
2022-2025
Epigénétique et Destin Cellulaire
2022-2025
Nanjing University
2025
Guangdong Academy of Agricultural Sciences
2020-2024
Ministry of Agriculture and Rural Affairs
2020-2024
Nanjing University of Chinese Medicine
2024
China-Japan Friendship Hospital
2024
Hunan Agricultural University
2023-2024
Guangxi Medical University
2014-2024
Antibiotic resistance genes (ARGs) are emerging contaminants, which have been frequently detected in different aquatic environments, posing potential risk to public health and ecosystem. A properly designed operated wastewater treatment process can be an effective final barrier for reducing the quantity of ARGs discharged into environment. In order control propagation antimicrobial environment, it is essential comprehensively understand elimination inactivation by various processes. This...
Chemotherapy-induced premature ovarian failure (POF) is a severe complication affecting tumor patients at childbearing age. Mesenchymal stem cells (MSCs) can partially restore the structure and function damaged by chemotherapy. miR-21 microRNA that regulate cell apoptosis. This study discusses repair effect mechanism of MSCs overexpressing on chemotherapy-induced POF. Rat granulosa (GCs) were isolated in vitro. transfected with lentiviral vector (LV-miR-21) to obtain stably expressing...
Abstract Background The small brown planthopper ( Laodelphax striatellus ) is an important agricultural pest that not only damages rice plants by sap-sucking, but also acts as a vector transmits stripe virus (RSV), which can cause even more serious yield loss. Despite being model organism for studying entomology, population biology, plant protection, molecular interactions among plants, viruses and insects, few genomic sequences are available this species. To investigate its transcriptome...
Abstract Gefitinib (Iressa, ZD-1839), a small molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) pathway, is currently under investigation in clinical trials for treatment colorectal cancer (CRC). However, as known, some patients develop resistance to TKIs and mechanisms mediating intrinsic EGFR-TKIs CRC have not been fully characterized. Resistance EGFR inhibitors reportedly involves activation signal transducer activator transcription 3 (STAT3) glioma...
Abstract DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It yet unclear if UHRF1 functions solely by stimulating DNMT1, or it has important additional functions. Using degron alleles, we show that depletion causes a much greater loss of than DNMT1 depletion. This not caused passive demethylation as UHRF1-depleted cells proliferate more slowly DNMT1-depleted cells. Instead, bioinformatics, proteomics genetics...
: The apoptosis of pulmonary artery endothelial cells (PAECs) is an important factor contributing to the development hypertension (PH), a serious cardio-pulmonary vascular disorder. Salidroside (SAL) bioactive compound derived from herb Rhodiola, but potential protective effects SAL on PAECs and underlying mechanisms remain elusive. objective this study was determine role in hypoxia-induced dissect mechanisms. Male Sprague-Dawley (SD) rats were subjected hypoxia (10% O2) for 4 weeks...
The intestinal tract plays an important role in digestion and absorption, nutrient metabolism, immune anti-stress. At the same time, intestine is also major site for pathogens various harmful substances to invade. Probiotics, as living microbial agents, improve animal health by maintaining microecological balance of host's flora. To explore protective effect Clostridium butyricum (CB) on gut, we investigated changes digestion, antioxidant, gut microbiota juvenile largemouth bass. fish were...
Abstract Background Long non-coding RNAs (lncRNAs) have emerged as biomarkers and important regulators of tumor development progression. PANDAR (promoter CDKN1A antisense DNA damage activated RNA) is a novel long RNA that acts potential biomarker involves in multiple cancers. However, the clinical significance molecular mechanism bladder cancer still unknown. In this study, we aimed to figure out role cancer. Methods The relative expression level lncRNA was determined by Real-Time qPCR total...
CD3 bispecific antibody constructs recruit cytolytic T cells to kill tumor cells, offering a potent approach treat cancer. cell activation is driven by the formation of trimolecular complex (trimer) between drugs, and mimicking an immune synapse. A translational quantitative systems pharmacology (QSP) model proposed for molecules capable predicting trimer concentration linking it killing. The was used quantify pharmacokinetic (PK)/pharmacodynamic (PD) relationship targeting P-cadherin...
Insect vitellogenin (Vg) has been considered to be synthesized in the fat body. Here, we found that abundant Vg protein is Laodelphax striatellus hemocytes as well. We also determined only hemocyte-produced binds Rice stripe virus (RSV) vivo. Examination of subunit composition L. (LsVg) revealed LsVg was processed differently after its expression different tissues. The able bind RSV exist stably hemocytes, while body-produced lacks RSV-interacting subunit. Nymph and male individuals...
Abstract Objective The majority of individuals with femoral neck fractures opt for total hip replacement to enhance their quality life. However, this group frequently exhibits perioperative symptoms pain, anxiety, and sadness, which extends recovery time some extent. Esketamine, the right-handed monomer ketamine, is more popular these days due its sedative, analgesic, antidepressant properties. There are currently few domestic international research on use esketamine in elderly who have...
Plants have evolved multiple mechanisms to selectively suppress pathogens by production of secondary metabolites with antimicrobial activities. Therefore, direct selections for antiviral compounds from plants can be used identify new agents potent activity but not toxic hosts. Here, we provide evidence that a class compounds, seco-pregnane steroid glaucogenin C and its monosugar-glycoside cynatratoside A Strobilanthes cusia three pantasugar-glycosides Cynanchum paniculatum, are effective...
Antibody drug conjugates enable the targeted delivery of potent chemotherapeutic agents directly to cancerous cells. They are made by chemical conjugation cytotoxins monoclonal antibodies, which can be achieved first reducing interchain disulfide bonds followed resulting free thiols with drugs. This process yields a controlled, but heterogeneous, population conjugated products that contains species various numbers drugs linked different former cysteine residues on antibodies. We have...
Background/Aims: Several miRNAs have been reported to be involved in the pathogenesis of polycystic ovarian syndrome (PCOS). However, biological roles miR-16 and its molecular mechanisms PCOS development remain elucidated. Methods: qRT-PCR was performed detect expression levels programmed cell death protein 4 (PDCD4). GCs proliferation, cycle distribution apoptosis were examined by MTT assay flow cytometry analysis. Luciferase reporter RIP applied confirm regulatory relationship between...
Humantenine, an alkaloid isolated from the medicinal herb Gelsemium elegans (Gardner & Chapm.) Benth., has been reported to induce intestinal irritation, but underlying toxicological mechanisms remain unclear. The object of present study was investigate RNA N6-methyladenosine (m6A) modification and distinct mRNA transcriptome profiles in humantenine-treated HCT116 human colon cancer cells. High-throughput MeRIP-seq mRNA-seq were performed, bioinformatic analysis performed reveal role...
Corydalis saxicola , an endangered medicinal plant endemic to karst habitats, is widely used in Traditional Chinese Medicine treat hepatitis, abdominal pain, bleeding hemorrhoids and other conditions. However, date, the mitochondrial (mt) genome of C. has not been reported, which limits our understanding genetic biological mechanisms . Here, mt was assembled by combining Nanopore Illumina reads. The represented a circular chromosome 587,939 bp length, with overall GC content 46.50%. 40...