A5083410699- Berberine and alkaloids research
- Gout, Hyperuricemia, Uric Acid
- Essential Oils and Antimicrobial Activity
- Ginger and Zingiberaceae research
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Genomics, phytochemicals, and oxidative stress
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Alcohol Consumption and Health Effects
- Inflammasome and immune disorders
- Phytochemistry and Biological Activities
- Advanced Fiber Laser Technologies
- Nonlinear Photonic Systems
- Plant biochemistry and biosynthesis
- Liver Disease Diagnosis and Treatment
- Alkaloids: synthesis and pharmacology
- Phytochemistry and Bioactive Compounds
- Orbital Angular Momentum in Optics
- Inflammatory Bowel Disease
- Phytochemical Studies and Bioactivities
- Cannabis and Cannabinoid Research
- Phytochemistry and biological activity of medicinal plants
- Diet, Metabolism, and Disease
- Tryptophan and brain disorders
Guangzhou University of Chinese Medicine
2016-2025
Shanxi Academy of Medical Sciences
2022-2025
Shanxi Medical University
2024-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2024
Sichuan Agricultural University
2020-2021
Wuhan University
2018-2019
Peking University
2017
Peking University People's Hospital
2017
The 180th Hospital of PLA
2010-2016
Berberine (BBR) is a promising anti-diabetic isoquinoline alkaloid from Rhizoma coptidis, while its bioavailability was extremely low. Here, the existing form and pharmacokinetics of BBR were comparatively characterized in conventional antibiotic-induced pseudo germ-free (PGF) rats. Furthermore, we investigated antidiabetic effect potential mechanism intestinal oxidative metabolite oxyberberine (OBB) STZ-induced diabetic Results showed that OBB existed mainly as protein-bound blood,...
Phellodendri Chinese Cortex has long been used to treat hyperuricemia and gout. Berberine (BBR), its characteristic ingredient, also shown be effective in alleviating monosodium urate crystals-triggered gout inflammation vitro vivo . Dihydroberberine (DHB) is a hydrogenated derivative of BBR that showed improved efficacy on many metabolic disorders. However, anti-hyperuricemia effect remains underexplored. In the present work, hypouricemic renoprotective effects DHB hyperuricemic mice were...
Purpose: Gouty arthritis could be triggered by the deposition of monosodium uric acid (MSU) crystals. Palmatine (PAL), a protoberberine alkaloid, has been proven to possess compelling health-beneficial activities. In this study, we aimed explore effect PAL on LPS plus MSU crystal-stimulated gouty in vitro and vivo. Methods: PMA-differentiated THP-1 macrophages were primed with then stimulated crystal presence or absence PAL. The expression pro-inflammatory cytokines oxidative stress-related...
Coptisine, one of the main active components Rhizoma Coptidis, possesses anti-inflammatory, antioxidant, anti-apoptosis and renoprotective effects. In this study, we investigated protective effect coptisine against hyperuricemia induced renal injury in vitro vivo, determined underlying mechanism. vivo experiment, a mouse model acute was established using potassium oxonate (PO)/ hypoxanthine (HX), HK-2 cells by uric acid (UA). Results showed that treatment significantly attenuated via...
Pogostemonis Herba has long been used in traditional Chinese medicine for the treatment of inflammation-related disorders. Patchouli alcohol (PA) isolated from is a tricyclic sesquiterpene that known to exert variety pharmacological activities. The present study aimed investigate anti-inflammatory effect PA on lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Pre-treatment with at concentrations 10, 20 or 40 μM dose-dependently decreased production tumor necrosis factor (TNF)-α,...
Excessive alcohol consumption leads to serious liver injury, associating with oxidative stress and inflammatory response. Previous study has demonstrated that polydatin (PD) exerted antioxidant anti-inflammatory effects attenuated ethanol-induced damage, but the research remained insufficient. Hence, this experiment aimed evaluate hepatoprotective effect potential mechanisms of PD on hepatotoxicity. Our results showed pretreatment dramatically decreased levels alanine aminotransferase (ALT),...
Patchouli alcohol (PA), a tricyclic sesquiterpene, is the major chemical component of patchouli oil. This study investigated antidepressant-like effect and mechanism PA in chronic unpredictable mild stress (CUMS). Our results showed that markedly attenuated CUMS-induced depressant-like behaviors, including an effective increase sucrose preference spontaneous exploratory capacity, as well reduction immobility time. In addition, mTOR, p70S6K, 4E-BP-1 phosphorylation hippocampus. Furthermore,...
Berberine (BBR) is an active component of Phellodendri Cortex (PC), which a traditional Chinese medicine that has been prescribed clinically for hyperuricemia (HUA) hundreds years. Many studies reported the anti-inflammatory and nephroprotective properties BBR PC; however, therapeutic effects on HUA have not explored. This study aims to investigate efficacy mechanism treating HUA.The in treatment were predicted by network pharmacology. A mouse model established potassium oxonate hypoxanthine...
Palmatine (PAL) and berberine are both classified as protoberberine alkaloids, derived from several traditional Chinese herbs such Coptis chinensis Franch. Phellodendron chinense Schneid. These compounds extensively used in treating dysentery colitis. PAL is one of the crucial quality markers for these plants Pharmacopoeia. A key metabolite PAL, 8-Oxypalmatine (OPAL), shows favorable anti-inflammatory activity better safety compared to though its mechanisms ulcerative colitis (UC) not fully...
Alterations in intestinal microbiota have been identified as a key risk factor rheumatoid arthritis (RA). This study presents multidimensional gut profile from large cohort of RA patients, stratified by disease stage and treatment regimens, compared to healthy controls. Our dataset comprises profiles 2,238 individuals, including 1,034 patients (Ascia Pacific cohort, APRAC) 1,204 is enriched with detailed clinical metadata, patient profiles, histories, environmental factors, providing...