A5101670333- Berberine and alkaloids research
- Alkaloids: synthesis and pharmacology
- Ginseng Biological Effects and Applications
- Magnolia and Illicium research
- Gout, Hyperuricemia, Uric Acid
- Cancer Mechanisms and Therapy
- Spinal Cord Injury Research
- Animal Diversity and Health Studies
- Wnt/β-catenin signaling in development and cancer
- Viral gastroenteritis research and epidemiology
- MicroRNA in disease regulation
- Orthopedic Infections and Treatments
- Medical Research and Treatments
- Healthcare Education and Workforce Issues
- Health and Wellbeing Research
- Pressure Ulcer Prevention and Management
- Phytochemical compounds biological activities
- Amoebic Infections and Treatments
- Traditional Chinese Medicine Studies
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Genomics, phytochemicals, and oxidative stress
- Acupuncture Treatment Research Studies
- Cerebral Palsy and Movement Disorders
- Pharmacological Effects of Natural Compounds
Lanzhou University
2023
Guangzhou University of Chinese Medicine
2019-2021
Lishui Central Hospital
2019-2021
Zhejiang University
2019
Berberine (BBR) is a promising anti-diabetic isoquinoline alkaloid from Rhizoma coptidis, while its bioavailability was extremely low. Here, the existing form and pharmacokinetics of BBR were comparatively characterized in conventional antibiotic-induced pseudo germ-free (PGF) rats. Furthermore, we investigated antidiabetic effect potential mechanism intestinal oxidative metabolite oxyberberine (OBB) STZ-induced diabetic Results showed that OBB existed mainly as protein-bound blood,...
Honokiol (HO) exerts neuroprotective effects in several animal models of Alzheimer's disease (AD), but the poor dissolution hampers its bioavailability and therapeutic efficacy.A novel honokiol nanoscale drug delivery system (Nano-HO) with smaller size excellent stability was developed this study to improve solubility HO. The anti-AD Nano-HO determined.Male TgCRND8 mice were daily orally administered or HO at same dosage (20 mg/kg) for 17 consecutive weeks, followed by assessment spatial...
Phellodendri Chinese Cortex has long been used to treat hyperuricemia and gout. Berberine (BBR), its characteristic ingredient, also shown be effective in alleviating monosodium urate crystals-triggered gout inflammation vitro vivo . Dihydroberberine (DHB) is a hydrogenated derivative of BBR that showed improved efficacy on many metabolic disorders. However, anti-hyperuricemia effect remains underexplored. In the present work, hypouricemic renoprotective effects DHB hyperuricemic mice were...
Berberine (BBR) is an active component of Phellodendri Cortex (PC), which a traditional Chinese medicine that has been prescribed clinically for hyperuricemia (HUA) hundreds years. Many studies reported the anti-inflammatory and nephroprotective properties BBR PC; however, therapeutic effects on HUA have not explored. This study aims to investigate efficacy mechanism treating HUA.The in treatment were predicted by network pharmacology. A mouse model established potassium oxonate hypoxanthine...
Brucea javanica oil (BJO), one of the main products javanica, has been widely used in treating different kinds malignant tumors. Quassinoids are major category anticancer phytochemicals B. javanica. However, current researches on anti-cancer effect BJO mainly focused oleic acid and linoleic acid, common components dietary edible oils, essential characteristic like quassinoids potentially involved remained unexplored. In investigation, we developed an efficient HPLC method to detect brusatol,...
To investigate the employment status, readiness, and other factors affecting ease or difficulty with which breast cancer patients effect their return to work (RTW). This study adopted a mixed-method design, recruiting participants from among in hospital Hunan December 2018 June 2019. We approached 300 individuals, 192 of whom ultimately participated this study. The quantitative part involved several scales: Patient Health Questionnaire-9 (PHQ-9), Brief Fatigue Inventory (BFI), Work Ability...
Brucea javanica is an important Chinese folk medicine traditionally used for the treatment of dysentery (also known as inflammatory bowel diseases). oil emulsion (BJOE), most common preparation javanica, has a variety pharmacological activities. In this follow-up investigation, we endeavored to illuminate potential benefit BJOE on 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced Crohn's disease (CD) in rats and decipher mechanism action. The result illustrated that significantly reduced...
The study aim was to analyse the effect of participatory continuous nursing using WeChat platform on complications, family function and compliance patients with spinal cord injuries.
This study aims to explore the effects of an online home nursing care model application on patients with traumatic spinal cord injury (TSCI).Eighty TSCI discharged from hospital between January 2015 and 2018 were included in study. The randomly divided into two groups: control group observation (n = 40, each). given routine discharge guidance, while care. Oswestry Disability Index (ODI), Medical Outcomes Study 36-item short-form health survey (MOS SF-36), complication-incidence rate used...
Hepatocellular carcinoma (HCC) has high mortality and incidence worldwide. The molecular mechanism associated with HCC is largely unexplored.To investigate the impact of CD44 knock-down on proliferation, migration, invasiveness in cells.Colony formation MTT assay were used to observe cellular proliferation viability. In addition, invasion migration studied by Transwell wound healing assays respectively. Finally, western blotting was utilized check protein expression levels.The metastasis...
SUMMARY OBJECTIVE: We describe the case of a diabetic patient who developed vertebral osteomyelitis and bilateral psoas abscess with gas formation due to klebsiella pneumoniae. METHODS: A 64-year-old woman 4-year history type-2 diabetes mellitus was admitted Emergency Department. The subject had 2-day high-grade fever associated chills 5-hour consciousness. She received empirical treatment febrifuge, after which her decreased. RESULTS: Her recurred an interval three hours. computed...
Abstract Background Honokiol (HO) exerts neuroprotective effects in several animal models of Alzheimer’s disease (AD), but the poor dissolution hampers its bioavailability and therapeutic efficacy. A novel honokiol nanoscale drug delivery system (Nano-HO) with smaller size excellent stability was developed this study to improve solubility HO. Methods Male TgCRND8 mice were administered Nano-HO or HO at same dosage (20 mg/kg) by oral gavage daily for 17 consecutive weeks, followed assessment...
Objective To observe the analgesic effect of warming and scraping in treatment patients with shoulder neck pain qi stagnation blood stasis type. Methods 120 type treated at our hospital form December, 2017 to August, 2018 were randomly divided into a blank group, moxibustion 30 cases for each group. The group did not use external traditional Chinese medicine. moxibustion, scraping, warming, scraping. effects 4 groups observed. Results The total effective rate was 92.9% 57.1%...
Objective To observe the short-term efficacy of warming and clearing scrapping therapy for patients with cervical headache. Methods Eighty outpatients headache were randomly divided into bullhorn board group group, 40 cases in each Department Orthopedics Third Affiliated Hospital Guangzhou University Chinese Medicine from June 2017 to October 2018. The treated by horn scraping plate (BS group) according meridians, while (WS moxibustion, scraping, thermotherapy massage. VAS...