A5066797487- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Testicular diseases and treatments
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Cardiac Structural Anomalies and Repair
- 14-3-3 protein interactions
- Plant and Fungal Interactions Research
- Urological Disorders and Treatments
- Infective Endocarditis Diagnosis and Management
- Colorectal Cancer Surgical Treatments
- Cancer Mechanisms and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
Lanzhou University
2018-2024
First Hospital of Lanzhou University
2018-2024
Jiangxi Agricultural University
2022
Lanzhou University Second Hospital
2021
Zero to Three
2020
Early gastric cancer (EGC), compared with advanced (AGC), has a higher 5-year survival rate. However, due to the lack of typical symptoms and difficulty in diagnosing EGC, no effective biomarkers exist for detection gastroscopy is only method.To provide new high specificity sensitivity through analyzed differentially expressed microRNAs (miRNAs) EGC AGC them those benign gastritis (BG).We examined miRNAs plasma 30 patients AGC, BG by miRNA chip analysis. Then, we selected significantly...
<h3>Importance</h3> Few studies have examined the clinicopathological characteristics and prognoses of patients with hepatoid adenocarcinoma stomach (HAS). <h3>Objective</h3> To explore HAS develop a nomogram to predict overall survival (OS). <h3>Design, Setting, Participants</h3> This prognostic study involved retrospective analysis data from 315 who received diagnosis primary between April 1, 2004, December 31, 2019, at 14 centers in China. <h3>Main Outcomes Measures</h3> OS factors....
Background and objectives Anastomotic leakage (AL) is one of the most serious complications after laparoscopic anus-preserving surgery for rectal cancer, which significantly prolongs patient’s hospital stay, leads to dysfunction, even increases perioperative morbidity mortality, little known about effectiveness anastomotic reinforcement sutures prevent AL. Thus, this study was conducted evaluate efficacy as a means AL during cancer. Methods A comprehensive systematic search performed in...
Gastric cancer most commonly occurs in East Asia, and China accounts for more than half the of world's gastric burden. Despite efficacy chemotherapy patients, this treatment leads to significant patient inconvenience, toxicity cost. The present study aimed assess a non-toxic agent, glabridin, as future chemotherapeutic approach treating cancer. Using cell proliferation, apoptosis, invasion, colony formation assays, it was determined that glabridin alone, or combination with 5-fluorouracil...
The human ubiquitin protein ligase E3 component N-recognin 5 (UBR5) gene, which is localized to chromosome 8q22, encodes an ~10 kb mRNA and a >300 kDa protein, can be detected in number of cell types. UBR5 implicated several types cancer, including ovarian gallbladder cancer lymphoma; however, its role gastric not completely understood. In the present study, expression levels tissues lines were examined via immunohistochemistry, reverse transcription-quantitative PCR analysis western...
RNA-binding proteins have been associated with cancer development. The overexpression of a well-known protein, insulin-like growth factor 2 messenger protein 3, has identified as an indicator poor prognosis in patients various types cancer. Although gastric is relatively frequent and potentially fatal malignancy, the mechanism by which 3 regulates development this remains unclear. This study aimed to investigate role regulatory An analysis IGF2BP3 expression patterns reported 4 public...
To develop a CT-based radiomics nomogram for the high-precision preoperative differentiation of gastric hepatoid adenocarcinoma (GHAC) patients from (GAC) patients.108 with GHAC 6 centers and 108 GAC matched by age, sex T stage undergoing pathological examination were retrospectively reviewed. Patients 5 divided into two cohorts (training internal validation) at 7:3 ratio, remaining external test cohort. Venous-phase CT images retrieved tumor segmentation feature extraction. A model was...
Long non‑coding RNA high expression in hepatocellular carcinoma (lncRNA HEIH) acts as an oncogene multiple tumors, including carcinoma, colorectal cancer, melanoma and non‑small cell lung cancer. However, the role of HEIH breast cancer remains unknown. The present study focused on clinical significance biological function Specifically, levels tissues lines were investigated. results indicated human tissues, its was positively associated with malignancy status poor disease prognosis. High...
Background Although Helicobacter pylori (Hp) as high risk factor for gastric cancer have been investigated from human trial, present data is inadequate to explain the effect of Hp on changes metabolic phenotype in different stages. Purpose Herein, plasma superficial gastritis (Hp negative and positive), early advanced analyzed by UPLC-HDMS metabolomics can not only reveal patients with degrees (30 negative, 30 positive, 20 patients, 10 patients), but also auxiliarily diagnose cancer. Results...
Background Cyclocybe chaxingu is an edible and medicinal fungal species commonly cultivated in China. The major problems currently facing by growers of C. the random labeling strains aging degeneration. Therefore, evaluation genetic diversity essential for conservation reproducing programs this species. Methods In present study, 24 widely were collected from main producing areas China, analysis was performed. DNA polymorphism among these Chinese analyzed using inter-simple sequence repeat...
Hepatocellular carcinoma (HCC) has high mortality and incidence worldwide. The molecular mechanism associated with HCC is largely unexplored.To investigate the impact of CD44 knock-down on proliferation, migration, invasiveness in cells.Colony formation MTT assay were used to observe cellular proliferation viability. In addition, invasion migration studied by Transwell wound healing assays respectively. Finally, western blotting was utilized check protein expression levels.The metastasis...
We report a case of patient with Stage IIIa Hepatocellular Carcinoma Complicated by Early Gastric Cancer. Although liver cancer can be treated surgery, the overall prognosis surgery is not ideal. Alternatively, conversion therapy reported different effectiveness towards stage cancer. Herein, this study shared successful and early gastric at Lanzhou University First Hospital, which hoped to engage clinicians in evaluation discussion.
The current TNM staging system for pancreatic ductal adenocarcinoma (PDAC) has revised the definitions of T and N categories as well stage groups. However, studies validating these modifications have yielded inconsistent results. existing in prognostic prediction remains unsatisfactory. prognosis PDAC is closely associated with pathological biological factors. Herein, we propose a new incorporating distant metastasis, postoperative serum levels CA19-9 CEA, tumor size, lymph node...
Background: The T and N categories stage groups are redefined in the current TNM staging system for pancreatic ductal adenocarcinoma (PDAC). Studies that validated these changes have yielded inconsistent results. This study aims to develop a new predict prognosis of PDAC.Methods: A total 693 patients who underwent pancreatectomy with curative intent PDAC were retrospectively enrolled. survival predictive model was developed by Cox proportional hazards analysis. An independent cohort used...