A5115591531- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Bone and Joint Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacological Effects and Toxicity Studies
- Tuberculosis Research and Epidemiology
- Gut microbiota and health
- Cardiovascular Function and Risk Factors
- Advanced MIMO Systems Optimization
- Folate and B Vitamins Research
- Particle physics theoretical and experimental studies
- Syphilis Diagnosis and Treatment
- Natural Compounds in Disease Treatment
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Vitamin D Research Studies
- Cytomegalovirus and herpesvirus research
- Physiological and biochemical adaptations
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Lanzhou Jiaotong University
2025
Shougang (China)
2025
First Hospital of Lanzhou University
2022-2024
Lanzhou University
2022-2024
First Affiliated Hospital of Bengbu Medical College
2024
Capital Medical University
2023-2024
Chinese Academy of Fishery Sciences
2024
Beijing Anzhen Hospital
2024
Composition of the gut microbiota has been linked with human immunedeficiency virus (HIV)-infected patients on antiretroviral therapy (ART). Evidence suggests that ART-treated poor CD4+ T-cell recovery have higher levels microbial translocation and immune activation. However, association remains unclear. We performed a cross-sectional study 30 healthy controls (HC) 61 HIV-infected individuals, including 15 immunological ART responders (IRs), 20 non-responders (INRs) 26 untreated individuals...
The molecular epidemiology of the HIV-1 CRF01_AE subtype as a risk factor for fast progression remains poorly understood. We analyzed tropism by utilizing samples from 201 treatment-naive patients in our multicenter cohort (12 research centers different provinces China). Tropism was determined V3 loop sequencing. Data 235 infected sexually (including aforementioned patients) this with date estimated seroconversion (EDS) were retrospectively evaluated. Median time EDS to AIDS Kaplan-Meier...
Introduction Liver disease related to hepatitis B (HBV) and C (HCV) may temper the success of antiretroviral therapy (ART) in China. Limited data exist on their prevalence HIV‐positive Chinese. A multi‐centre, cross‐sectional study was carried out determine characteristics HBV HCV co‐infection patients across 12 provinces. Methods ART‐naïve were recruited from two parent cohorts established during November 2008–January 2010 August 2012–September 2014. Hepatitis surface antigen (HBsAg), e...
BackgroundTherapeutic approaches to HIV-suppressed immunological non-responders (INRs) remain unsettled. We previously reported efficacy of Chinese herbal Tripterygium wilfordii Hook F in INRs. Its derivative (5R)-5-hydroxytriptolide (LLDT-8) on CD4 T cell recovery was assessed.MethodsThe phase II, double-blind, randomized, placebo-controlled trial conducted adults patients with long-term suppressed HIV infection and suboptimal recovery, at nine hospitals China. The were 1:1:1 assigned...
This study aims to analyze the efficacy of anti-syphilis treatment and impact syphilis events on HIV virology immunology in HIV/syphilis co-infected patients long-term antiretroviral therapy (ART) investigate incidence factors recurrence/re-infection/serofast state. The insights derived from this investigation can potentially guide strategies for preventing managing AIDS. A retrospective case-control was conducted at AIDS clinic Peking Union Medical College Hospital January 2003 December...
ABSTRACT Channel state information (CSI) plays a critical role for beamforming technology in frequency division duplex (FDD) massive multiple‐input and multiple‐output (MIMO) systems. In order to improve the accuracy, we present novel codebook based CSI reconstruction algorithm enhance feedback performance, thereby improving communication quality. Based on existing mechanism, initially, leverage channel temporal correlation smooth precoding matrix using sliding window approach, where both...
With the development of entertainment industry and widespread use electronic devices, worship celebrities has become increasingly prevalent fervent, accompanied by a rise in cyberbullying. Applying general aggression model, our focus this study was on role fans’ reactive anger maternal rejection link between celebrity The participants were 847 college students. Analysis data from survey showed that both moderated relationship That is, when level high, predictive effect cyberbullying...
Abstract Introduction With the global scale-up of antiretroviral therapy (ART) and improved life expectancy, people living with HIV (PLWH) increasingly face non-infectious comorbidities, metabolic syndrome (MetS) is one most prevalent. MetS associated unfavorable health outcomes, including cardiovascular disease, chronic kidney dysfunction-associated fatty liver disease. However, data on prevalence risk factors among treatment-naïve PLWH in China are limited. The aim was to investigate...
Objective Bone mineral density (BMD) monitoring, primarily relying on dual-energy X-ray absorptiometry (DEXA), remains inaccessible in resource-limited regions, making it difficult to promptly address bone loss people with HIV (PWH) long-term ART-containing TDF regimens and assess the prevalence of loss. Our objective is identify frequency PWH experiencing after ART a regimen develop predictive model HIV-infected high-risk populations containing long-time ART, for providing more appropriate...
Rainbow trout (Oncorhynchus mykiss) was recognized as typical “glucose-intolerant” fish and poor dietary carbohydrate user. Our first objective to test the effect of carbohydrates itself (without modification protein intake) on hepatic glucose gene expression (taking into account paralogs. The second aim research if two isogenic lines had different responds intake, showing one with a better use carbohydrates. Thus, we used rainbow (named A32h AB1h) fed either high diet or low for 12 weeks....
Purpose The incomplete immune reconstitution is a complex phenomenon among human immunodeficiency virus (HIV)-infected patients despite the fact that they have achieved persistent viral suppression under combined antiretroviral therapy. This study aims to screen and verify immunological characteristics underlying mechanisms of non-responders (INRs). Methods RNA-seq differentially expressed genes (DEGs) analysis were used explore potential INRs. Gene Ontology (GO) enrichment, ingenuity...
Chronic metabolic changes relevant to human immunodeficiency virus type 1 (HIV-1) infection and in response antiretroviral therapy (ART) remain undetermined. Moreover, links between dysfunction caused by HIV immunological inflammation long-term treated individuals have been poorly studied.Untargeted metabolomics inflammatory cytokine levels were assessed 47 HIV-infected including 22 responders (IRs) 25 non-responders (INRs) before after ART. The IRs INRs matched age, gender, baseline viral...
Abstract Background The aim of this study was to investigate the impact a tenofovir disoproxil fumarate (TDF) plus ritonavir-boosted protease inhibitor (PI/r) regimen on renal function in Chinese HIV-infected patients. Methods Seventy-five HIV-1 infected patients failing first-line antiretroviral therapy (ART) comprised TDF+PI/r group. matched for gender, age, and made up control. All subjects completed follow-up visits over 48 weeks. CD4 cell count, plasma viral load, urine protein level...
The HIV-1 DNA reservoir is an important marker that reflects viro-immunological status and can be affected by multiple viral or cellular factors. Determining the potential factors associated with size of benefits surveillance disease progression antiretroviral treatments.We conducted a case control study to explore may affect level DNA. total in peripheral blood at 5 time points was quantified quantitative PCR. Chronically HIV-1-infected patients whose cell-associated levels were below...
The HIV-1 infected immunological non-responders (INRs) are characterized by poor immune reconstitution after long-term treatment. Tripterygium Wilfordii Hook F (TwHF) pill is a traditional Chinese patent drug with extensive immunosuppressive effects and has been clinically proven efficacy in treating INRs.The therapeutic mechanism of TwHF pills the treatment INRs was investigated combined multi-omics analysis on clinical samples network pharmacology approach.Clinically, peripheral blood...
Persons living with human immunodeficiency virus (HIV) are at increased risk of developing cardiovascular disease. Few studies have focused on echocardiographic abnormalities in this population.China AIDS Clinical Trial 0810 is a prospective, multicenter cohort study persons HIV (PLWH). We performed an echocardiography substudy 325 PLWH. examined the prevalence left ventricular systolic dysfunction (LVSD), diastolic (DD), pulmonary arterial hypertension (PAH), and mass (ILVM) antiretroviral...
Abstract Aim The aim of the study was to evaluate prevalence and risk factors chronic kidney disease ( CKD ) among HIV ‐infected antiretroviral therapy ART )‐naïve patients in M ainland C hina. Methods In this multicenter cross‐sectional study, glomerular filtration rate GFR calculated using odification D iet R enal isease MDRD equation. defined as < 60 mL/min per 1.73 m 2 and/or isolated proteinuria (≥1 + on urine dipstick) that persisted at month 3 after baseline assessment. Risk...
Background:Despite combination antiretroviral therapy (cART), 20% of HIV-infected patients are unable to achieve adequate immunologic recovery, in which immune activation plays a crucial role. We hypothesize that extract Tripterygium wilfordii Hook F (TwHF), Chinese medication used treat autoimmune diseases, has immunomodulatory effects may help CD4 cell recovery.Methods:Eighteen cART-treated virally suppressed for over 12 months with suboptimal recovery were enrolled. TwHF was administered...
Cardiovascular disease (CVD) is an important cause of mortality among HIV-infected patients, however little known about the burden CVD this population in Asia. We sought to quantify prevalence risk factors, 10-year risk, and patterns factor treatment a group individuals with HIV China. retrospectively analyzed baseline data from treatment-naïve adults enrolled two multicenter clinical trials Data regarding factors such as smoking, hypertension, diabetes, dyslipidemia obesity were assessed....
Although combination antiretroviral therapy (cART) including tenofovir (TDF)+lamivudine (3TC) or emtricitabine (FTC) is recommended for treatment of HIV/HBV coinfected patients, TDF unavailable in some resource-limited areas. Some data suggest that 3TC monotherapy-based cART may be effective patients with low pretreatment HBV DNA.Prospective study 151 Chinese subjects whom 60 received 3TC-based and 91 TDF+3TC-based cART. Factors associated DNA suppression at 24 48 weeks, anti-HBV drugs,...
Abstract Background Antiretroviral therapy (ART) improved the prognosis of people living with human immunodeficiency virus (HIV) (PLWH). Life-long treatment is required in PLWH and accompanied by various metabolic abnormalities disease course. Data about epidemiology dynamic changes dyslipidemia receiving antiretroviral were scarce Asian countries. This study aimed to explore risk factors analyze longitudinal among Chinese HAART. Methods We conducted a analysis enrolled two large multicenter...
Vaccination is an essential measure to stop the coronavirus disease 2019 (COVID-19) pandemic. We report a case of viral activation and CD4+ T cell loss in treatment-naïve HIV-positive patient after receiving inactivated COVID-19 vaccine (Sinopharm). The should probably be given only people living with HIV antiretroviral therapy.