A5075051424- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- COVID-19 Clinical Research Studies
- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- COVID-19 and Mental Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Natural Antidiabetic Agents Studies
- Sepsis Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- COVID-19 and healthcare impacts
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cytomegalovirus and herpesvirus research
- Dermatological and COVID-19 studies
- Parathyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Immunotherapy and Immune Responses
- Thyroid Cancer Diagnosis and Treatment
Ruijin Hospital
2020-2025
Shanghai Jiao Tong University
2025
Chongqing University of Technology
2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2025
University of Electronic Science and Technology of China
2025
Renmin Hospital of Wuhan University
2020-2024
Wuhan University
2011-2024
Hefei University of Technology
2024
Chiba University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2023
Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in patients with hypertension. Objective: To determine the association between in-hospital use ACEI/ARB all-cause mortality hypertension hospitalized due to COVID-19. Methods Results: This retrospective, multi-center study included 1128 adult diagnosed COVID-19, including 188 taking (ACEI/ARB group;...
The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a series of clinical symptoms and severe illnesses, including acute respiratory distress syndrome (ARDS) fatal organ failure. We report the fundamental pathological investigation in lungs other organs cases for mechanistic understanding development specific therapy these cases.
Severe acute respiratory syndrome (SARS) is caused by a coronavirus (SARS-CoV) and has the potential to threaten global public health socioeconomic stability. Evidence of antibody-dependent enhancement (ADE) SARS-CoV infection in vitro non-human primates clouds prospects for safe vaccine. Using antibodies from SARS patients, we identified characterized B-cell peptide epitopes with disparate functions. In rhesus macaques, spike glycoprotein peptides S471-503, S604-625, S1164-1191 elicited...
Abstract Background COVID-19 is a viral respiratory disease caused by the severe acute syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this may be more prone to venous or arterial thrombosis because of activation many factors involved in it, including inflammation, platelet and endothelial dysfunction. Interferon gamma inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) macrophage inflammatory protein 1-alpha (MIP1α) are cytokines related thrombosis. Therefore,...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spread mainly through droplets or direct contact. However, the infection condition of genital system unknown. Our aim in this study was to determine if SARS-CoV-2 present vaginal fluid women with disease 2019 (COVID-19). Methods Ten confirmed severe COVID-19 pneumonia admitted Tongji Zhongfa Hospital intensive care unit from 4 February 2020 24 were included. Clinical records, laboratory results, and computed...
Objective Coagulopathy is one of the characteristics observed in critically ill patients with coronavirus disease 2019 (COVID‐19). Antiphospholipid antibodies (aPLs) contribute to coagulopathy, though their role COVID‐19 remains unclear. This study was undertaken determine prevalence and aPLs COVID‐19. Methods Sera collected from 66 who were 13 not tested by chemiluminescence immunoassay for anticardiolipin (aCLs), anti–β 2 ‐glycoprotein I (anti‐β GPI) (IgG, IgM, IgA), IgG anti‐β GPI–domain...
The prognostic power of circulating cardiac biomarkers, their utility, and pattern release in coronavirus disease 2019 (COVID-19) patients have not been clearly defined. In this multicentered retrospective study, we enrolled 3219 with diagnosed COVID-19 admitted to 9 hospitals from December 31, March 4, 2020, estimate the associations injury markers poor outcomes COVID-19. mixed-effects Cox model, after adjusting for age, sex, comorbidities, adjusted hazard ratio 28-day mortality hs-cTnI...
This report demonstrates that a rapid decrease of peripheral T cell subsets is unique characteristic in patients with SARS during acute infection, although total white blood counts, red and platelet counts remain relatively normal. In recovering patients, dramatic restoration was seen the periphery. Although underlying mechanism observed stage remains unknown, this clinical can facilitate an earlier more accurate diagnosis SARS.
Aging is a major risk factor for several conditions including neurodegenerative, cardiovascular diseases and cancer. Functional impairments in cellular pathways controlling genomic stability, immune control have been identified. Biomarker of senescence needed to improve vaccine response develop therapy control. To identify phenotypic signature circulating cells with aging, we enrolled 1068 Chinese healthy volunteers ranging from 18 80 years old. The decreased naïve CD4+ CD8+ T cells,...
Antigenic peptides recognized by virus-specific cytotoxic T lymphocytes (CTLs) are presented major histocompatibility complex (MHC; or human leukocyte antigen [HLA] in humans) molecules, and the peptide selection presentation strategy of host has been studied to guide our understanding cellular immunity vaccine development. Here, a severe acute respiratory syndrome coronavirus (SARS-CoV) nucleocapsid (N) protein-derived CTL epitope, N1 (QFKDNVILL), restricted HLA-A*2402 was identified series...
Composition of the gut microbiota has been linked with human immunedeficiency virus (HIV)-infected patients on antiretroviral therapy (ART). Evidence suggests that ART-treated poor CD4+ T-cell recovery have higher levels microbial translocation and immune activation. However, association remains unclear. We performed a cross-sectional study 30 healthy controls (HC) 61 HIV-infected individuals, including 15 immunological ART responders (IRs), 20 non-responders (INRs) 26 untreated individuals...
Background: The complications of coronavirus disease 2019 (COVID-19) involved multiple organs or systems, especially in critically ill patients. We aim to investigate the neurological patients with COVID-19. Methods: This retrospective single-center case series analyzed COVID-19 at intensive care unit Tongji Hospital, Wuhan, China from February 5 April 2, 2020. Demographic data, clinical and laboratory findings, comorbidities treatments were collected analyzed. Results: Among 86 confirmed...
Background. Approximately 20% of human immunodeficiency virus type 1 (HIV-1)--infected adults do not normalize their CD4+ T lymphocytes after long-term effective highly active antiretroviral therapy (HAART). The mechanistic basis for this failure is unclear. Methods. Seventy-four patients were followed up regularly 3–7 years. Patients with undetectable plasma viral load (<50 copies/mL) over 12 months further classified into 2 groups: (1) immunological nonresponders, whose T-cell count was...
The molecular epidemiology of the HIV-1 CRF01_AE subtype as a risk factor for fast progression remains poorly understood. We analyzed tropism by utilizing samples from 201 treatment-naive patients in our multicenter cohort (12 research centers different provinces China). Tropism was determined V3 loop sequencing. Data 235 infected sexually (including aforementioned patients) this with date estimated seroconversion (EDS) were retrospectively evaluated. Median time EDS to AIDS Kaplan-Meier...
Abstract Kaempferol (kaem) is a dietary flavonoid found in variety of fruits and vegetables. The inhibitory effects kaem on primary tumour growth have been extensively investigated; however, its metastasis are largely unknown. In the present study, we that significantly suppresses both lung mouse breast model. Furthermore, decreased expression citrullinated histone H3 (H3‐cit), biomarker neutrophil extracellular traps (NETs), had founded metastatic upon treated with kaem. reduction H3‐cit...
Abstract Background We investigated the feasibility of two biomarkers endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), their association with inflammation, coagulopathy, mortality. Methods The records 49 COVID-19 patients who were admitted to an intensive care unit (ICU) Wuhan, China between February April 2020 examined. Demographic, clinical, laboratory data, outcomes compared survivors non-survivors patients, high low serum Syndecan-1 levels....
Ganoderma lucidum polysaccharide peptide (GLPP) is one of the most abundant constituents (G. lucidum), with a wide range functional activities. The present study investigated immunomodulatory effects GLPP in cyclophosphamide (CTX)-induced immunosuppressive mice. results showed that 100 mg/kg/day administration significantly alleviated CTX-induced immune damage by improving organ indexes, earlap swelling rate, index carbon phagocytosis and clearance value, secretion cytokines (TNF-α, IFN-γ,...
Introduction Liver disease related to hepatitis B (HBV) and C (HCV) may temper the success of antiretroviral therapy (ART) in China. Limited data exist on their prevalence HIV‐positive Chinese. A multi‐centre, cross‐sectional study was carried out determine characteristics HBV HCV co‐infection patients across 12 provinces. Methods ART‐naïve were recruited from two parent cohorts established during November 2008–January 2010 August 2012–September 2014. Hepatitis surface antigen (HBsAg), e...
Abstract Context and Objective Parathyroid carcinoma (PCa) is a rare endocrine neoplasm known for its high recurrence. The specific molecular properties influencing the prognosis of PCa remain largely elusive. present study was designed to explore significance PI3K/AKT/mTOR activation in PCa. Methods Over 10-year period, 64 patients were recruited from dual centers. We analyzed mTORC1 activity 29 controls, comprising atypical parathyroid tumor (APT), adenoma (PAd) normal (PaN) tissues. A...
Abstract Diabetes is now a global chronic disease, with the number of people diabetes expected to reach 643 million by end 2030. Semaglutide, human glucagon-like peptide-1 (GLP-1) analogue 94% similarity GLP-1, can promote insulin secretion and repress glucagon in glucose concentration-dependent manner, resulting substantial improvement blood levels reducing risk hypoglycemia patients type 2 diabetes. To improve absorption efficiency semaglutide oral delivery, we developed chitosan...