A5044477809- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Inflammasome and immune disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chronic Kidney Disease and Diabetes
- Fuel Cells and Related Materials
- Protein Structure and Dynamics
- Heart Rate Variability and Autonomic Control
- Synthesis and properties of polymers
- Synthesis of Tetrazole Derivatives
- MRI in cancer diagnosis
- Synthesis and Characterization of Heterocyclic Compounds
- Liver Disease and Transplantation
- Machine Learning in Bioinformatics
- Gait Recognition and Analysis
- Advanced Glycation End Products research
- Radiology practices and education
- Curcumin's Biomedical Applications
- Ultrasound and Hyperthermia Applications
- Dendrimers and Hyperbranched Polymers
- Photoacoustic and Ultrasonic Imaging
Ruijin Hospital
2011-2025
Shanghai Jiao Tong University
2023-2025
Zhejiang Lab
2023-2024
Shanghai Institute of Hypertension
2010-2024
XinHua Hospital
2023-2024
Nanjing University of Science and Technology
2024
Fudan University
1998-2023
Zhongshan Hospital
2022-2023
Shanghai Public Health Clinical Center
2023
The First Affiliated Hospital, Sun Yat-sen University
2022
Advanced liver cancer is the most fatal malignant cancer, and clinical outcomes of treatment are not very satisfactory due to complexity heterogeneity tumor. Combination therapy can efficiently enhance tumor by stimulating multiple pathways regulating immune microenvironment. Nanodrug delivery systems have become attractive candidates for combined strategies treatment. This study reports a nano ultrasound contrast agent (arsenic trioxide (ATO)/PFH NPs@Au-cRGD) integrate diagnosis efficient...
Abstract Context and Objective Parathyroid carcinoma (PCa) is a rare endocrine neoplasm known for its high recurrence. The specific molecular properties influencing the prognosis of PCa remain largely elusive. present study was designed to explore significance PI3K/AKT/mTOR activation in PCa. Methods Over 10-year period, 64 patients were recruited from dual centers. We analyzed mTORC1 activity 29 controls, comprising atypical parathyroid tumor (APT), adenoma (PAd) normal (PaN) tissues. A...
The dynamic assessment of disease activity during the follow-up patients with Crohn's (CD) remains a significant challenge. In this study, we aimed to identify role contrast-enhanced ultrasound (DCE-US) in evaluation CD.
Malignant focal liver lesions (FLLs) represent various kinds of epithelial and mesenchymal tumors. In pediatric patients, the understanding diseases associated imaging manifestations is essential for making accurate diagnosis differential diagnosis. This paper will discuss latest knowledge common malignant FLLs, including undifferentiated embryonal sarcoma, rhabdomyosarcoma, epithelioid hemangioendothelioma, angiosarcoma, rhabdoid tumor. Medical features are not only helpful clinical...
To investigate the diagnostic value of resistance index (RI) in differentiating focal liver lesions.In this retrospective study, a total 576 patients with histologically confirmed lesions were included. Each patient underwent B-mode ultrasound examination and color Doppler examination. The RI values different recorded compared.The mean benign was significantly lower than that malignant (0.54 ± 0.10 vs. 0.71 0.12) (p <0.05). In lesions, intrahepatic cholangiocarcinoma hepatocellular carcinoma...
Objective: To evaluate the value of dynamic contrast-enhanced ultrasound (DCE-US) and quantitative parameters in early prediction tumor response to chemoradiotherapy (CRT) patients with locally advanced pancreatic ductal adenocarcinoma (LAPC). Patients Methods: In this prospective study, biopsy-proved histopathologically proved LAPC who underwent regular CRT were recruited. DCE-US evaluations performed before four months after CRT. SonoVue-enhanced (CEUS) was by an system (ACUSON Sequoia;...
Portal hypertension (PH) is a clinical syndrome, characterized by elevated pressure gradient between portal vein and inferior vena cava. These pressures due to increased vascular resistance and/or volume of blood flowing through the circulation, results in outflow difficulty from hepatic veins cava, eventually cause life-threatening complications including ascites, gastroesophageal varices, encephalopathy. In spite severity PH, it hard early diagnosis, as no liver-related symptom appears...
Objective: We investigated whether the long-half time dihydropyridine calcium-channel blocker amlodipine was more efficacious than gastrointestinal therapeutic system (GITS) formulation of nifedipine in lowering morning blood pressure ambulatory hypertension. Design and method: The study designed as a multicentre, randomized, parallel-group comparison trial patients with stages 1 2 clinic (mean 6 readings on occasions off antihypertensive medication, systolic 140–179 mm Hg and/or diastolic...
To investigate the Sonazoid-enhanced contrast-enhanced ultrasound (CEUS) features of hepatocellular carcinoma (HCC) in a non-cirrhosis liver background, comparison to those cirrhosis.In this retrospective study, 19 patients with surgery and histopathologically proven HCC lesions background were included regarding CEUS characteristics. Two radiologists evaluated according WFUMB (World Federation Societies for Ultrasound Medicine Biology) guidelines criteria. Thirty-six cirrhosis as control...
Fibrosis is the main pathological feature of aortic stiffness, which a common extracardiac comorbidity heart failure with preserved ejection fraction (HFpEF) and contributor to left ventricular (LV) diastolic dysfunction. Systemic low-grade inflammation plays crucial role in pathogenesis HFpEF development vascular fibrosis. In this study, we investigate inflammatory mechanism fibrosis using novel mouse model. LV dysfunction induced by high-fat diet (HFD) combined subcutaneous aldosterone...
Polyethylene oxide (PEO) with 4-amino-N-(2-pyrimidinyl) benzene sulfonamide (APBS; PEOas) at one end was used as a carrier polymer for attachment (via the hydroxyl group) of drugs such mustard. For this purpose, amine group PEOas protected first by formation Schiff's base; then PEOasBr and PEOasNH2 were prepared. In order to attach N,N-dichloroethyl (DCEA) PEOasNH2, DCEA hydrogen chloride salt reacted maleic anhydride first, resulting maleinamic acid (DCEMA) could react continuously in...
Objective: To investigate the comorbidity rate of diabetes or hypertension in cardiology outpatients with endocrinology diabetes. Design and method: A multi-center, cross-sectional, non-interventional disease registry study has been conducted a sample 2,510 enrolled from 20 departments, respectively. The demographic data, medical history physical examination results were recorded questionnaire on illness perception conducted. Diagnosis determined by measured blood pressure HbA1c (or FBG)....
Objective: Patients with peripheral arterial disease (PAD) may have elongated upstroke time in pulse waves the lower extremities. We investigated this measure as a diagnostic tool of PAD and predictor mortality elderly Chinese. Design method: In population-based prospective study (>=60 years), we recorded at left right ankles by pneumoplethysmography, calculated percentage per cardiac cycle. Diagnostic accuracy was compared conventional ankle-brachial index (ABI) method CT angiography....