A5102977821- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Cardiovascular Function and Risk Factors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Abdominal vascular conditions and treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Sodium Intake and Health
- Gout, Hyperuricemia, Uric Acid
- Vascular anomalies and interventions
- Peripheral Artery Disease Management
- Renal Diseases and Glomerulopathies
- Nutrition, Genetics, and Disease
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular and Diving-Related Complications
- Complement system in diseases
- Total Knee Arthroplasty Outcomes
- Aortic Thrombus and Embolism
- Cardiac Fibrosis and Remodeling
Shanghai Institute of Hypertension
2015-2024
Ruijin Hospital
2015-2024
First Affiliated Hospital of Zhengzhou University
2023
Shanghai Jiao Tong University
2009-2023
Southern University of Science and Technology
2019-2020
Jinan University
2019-2020
Shanghai Institutes for Biological Sciences
2016-2018
Chinese Academy of Sciences
2016-2018
Christie's
2016
Baker Heart and Diabetes Institute
2013-2015
Rationale: Inflammation and immunity play crucial roles in the development of hypertension. Complement activation-mediated innate immune response is involved regulation hypertension target-organ damage. However, whether complement-mediated T-cell functions could regulate blood pressure elevation still unclear. Objective: We aim to determine C3aR (complement component 3a receptor) C5aR 5a via modulating regulatory T cells (Tregs). Methods Results: showed that angiotensin II (Ang II)-induced...
Obstructive sleep apnea (OSA) is a risk factor of several cardiovascular diseases. We investigated the association between aortic root diameter and hypoxia-related parameters in hypertensive patients with OSA.Our study included 242 OSA (52 mild, 71 moderate, 119 severe). All underwent echocardiography for measuring polysomnography apnea-hypopnea index (AHI), oxygen desaturation index, time spent less than 90%.The 19.8% women had mean (±SD) age 49.9 ± 12.9 years, 33.4 2.6 mm, prevalence...
In our series of patients with primary aldosteronism, we compared diagnostic concordance and clinical outcomes after adrenalectomy between adrenal venous sampling (AVS) computed tomography (CT) imaging. Our retrospective analysis included 886 aldosteronism diagnosed in hospital 2005 2014. Of them, 269 CT unilateral disease were the on 126 follow-up data adrenalectomy. Hypertension was considered cured if systolic/diastolic blood pressure (BP) controlled (<140/90 mm Hg) without medication...
// Mo-Na Hong 1,2,* , Xiao-Dong Li 1,2,3,* Dong-Rui Chen 1,2 Cheng-Chao Ruan 1,2,3 Jian-Zhong Xu Jing Yong-Jie Wu Yu Ma Ding-Liang Zhu and Ping-Jin Gao 1 Department of Hypertension, State Key Laboratory Medical Genomics, Shanghai Ruijin Hospital, Jiao Tong University School Medicine, Shanghai, China 2 Institute 3 Vascular Biology Stem Cell Biology, Health Sciences, Institutes for Biological Chinese Academy Sciences * These authors have contributed equally as first to this article...
Objectives: We found impaired brachial flow-mediated dilation (FMD) was associated with the number of target organ damage (TOD) in 2007. The present study investigated whether FMD predicted TOD progression essential hypertension. Methods and results: Endothelium-dependent measured 280 adults At third year examination, 199 patients (mean age 62.5 ± 9.5, men 59.3%) were approached for participation our study. Patients divided into two groups: normal group (FMD ≥10) <10). In 0–1 at baseline, (n...
Adrenal venous sampling (AVS) is considered the gold standard for differentiating unilateral and bilateral forms of primary aldosteronism. Currently, almost all AVS procedures are performed via femoral vein access.The aim this study was to evaluate success rate safety an antecubital approach.In a retrospective multicenter involving 7 Chinese medical centers, patients with aldosteronism who underwent approach between January 2012 December 2018 were analyzed. Successful determined by...
Objective: The surgical technique, safety, efficacy, and clinical application value of the intra-neuroendoscopic technique (INET) for treatment subacute-chronic chronic septal subdural hematoma was investigated based on structure pathological features wall, critical factors growth recurrence were determined, in order to provide reference drug treatment. Methods: This non-randomized concurrent control study. A total 94 patients who met inclusion criteria recruited between May 2015 February...
Objective: The current study aimed to evaluate the role of Küpers’ score in predicting unilateral aldosteronism, and develop a modified Chinese patients with primary aldosteronism. Methods: retrospective included 406 aldosteronism who underwent successful adrenal venous sampling (AVS) were divided into (n = 211) bilateral 195) groups according AVS results. Normokalemia was noted both 64) 84) when plasma urinary aldosterone measured. Results: We evaluated prediction score, which had best...
Abstract BACKGROUND Performance of electrocardiographic (ECG) criteria for echocardiographically diagnosed left ventricular hypertrophy (LVH) in Chinese hypertensive patients is not well known. We investigated the accuracy various ECG diagnosis echocardiographic LVH according to new cutoff values mass (LVM) index (&gt;115 g/m2 men and &gt;95 women) patients. METHODS Our study included 702 consecutive inpatients including 92 (13.1%) concentric 121 (17.2%) eccentric on standard...
Minimally invasive endoscopic hematoma evacuation is widely used in the treatment of intracerebral hemorrhage. However, this technique still has room for improvement. The intra-neuroendoscopic (INET) a modified minimally technique, and we report its safety efficacy evacuating brain parenchyma hematomas by comparing it with cranial puncture drainage operation (CPDO). frontal, temporal, or occipital approaches were according to site bleeding. preoperative postoperative volumes, Glasgow Coma...
We investigated the left atrial myocardial deformation in patients with primary aldosteronism using speckle-tracking echocardiographic (STE) strain imaging technique.Our study included 107 [52 aldosterone-producing adenoma (APA) and 55 idiopathic hyperaldosteronism (IHA)] 50 hypertensive patients. performed conventional echocardiography to measure volume ejection fraction, STE estimate including peak velocity, rate calculate ratio of E/e' during ventricular systole as stiffness...
Primary aldosteronism (PA) may cause myocardial injury. We investigated dysfunction using speckle-tracking echocardiographic (STE) layer-specific strain in patients with PA.Our study included 62 PA (33 aldosterone-producing adenoma [APA] and 29 idiopathic hyperaldosteronism [IHA]) 30 primary hypertension. STE was acquired the GE Vivid E9 equipment. The longitudinal (LS) circumferential (CS) strains of endocardium, midmyocardium, epicardium (LSendo, LSmid, LSepi, CSendo, CSmid, CSepi) were...
The 2016 guideline on the work-up of primary aldosteronism recommended that patients with obstructive sleep apnea–hypopnea syndrome (OSAS) be screened. This study aimed to identify clinical characteristics snoring (PA) complicated by OSAS. Sixty-eight self-reported or witnessed and 609 non-snoring diagnosed PA between 2010 2015 were recruited in this retrospective study. Compared patients, had significantly (P < 0.05) higher body mass index (BMI), diastolic blood pressure (DBP), serum...
Objective: To analyze the clinicopathological characteristics of renal lesions in type 2 diabetic patients and to differentiate nephropathy (DN) from non-diabetic diseases(NDRD). Methods: Type who received biopsy Ruijin Hospital January 2011 December 2015 were recruited this study. Clinical history, laboratory results pathological data retrospectively collected. According findings, divided into 3 groups: DN, NDRD, DN+NDRD. Logistic model was applied explore independent clinical predictive...
Objective: We investigated right ventricular function using speckle tracking echocardiography (STE) in patients with primary aldosteronism. Methods: Our study included 51 aldosteronism and 50 age sex-matched hypertensive patients. performed two-dimensional to measure cardiac structure function. STE offline analysis on four-chamber (RV4CLS) free wall longitudinal strains (RVFWLS). Results: Primary patients, compared had a significantly ( P ≤ 0.045) greater left mass index (112.0 ± 22.6 vs....
Abstract Primary aldosteronism (PA) with unilateral adrenal disease can be cured or improved by adrenalectomy. Adrenal venous sampling (AVS) is recommended to identify patients for surgical management. However, surgeries based on computed tomography (CT) images are only advocated PA aged <35 visible adenoma. Herein, we aimed compare CT‐based and AVS‐based surgery outcomes adenomas different age groups. A total of 178 who underwent adrenalectomy between June 2018 January 2021 were included...
To investigate the relationship between common carotid artery diameter (CCA-D) and target organ damage (TOD) in essential hypertension.A total of 200 hypertensive patients were enrolled (mean age 62.5 ± 9.5, men 59.0%) classified into two groups by height-adjusted mean median CCA-D: with CCA-D/height less than 3.905 mm/m (n = 100, 50%) more 50%). Patients have higher left ventricular mass index (LVMI) (P < 0.001) prevalence hypertrophy (LVH) 0.001), intima-media thickness 0.008) sclerosis...