A5100393634- SARS-CoV-2 and COVID-19 Research
- Health Systems, Economic Evaluations, Quality of Life
- HIV/AIDS Research and Interventions
- Lung Cancer Treatments and Mutations
- Animal Virus Infections Studies
- Cancer Genomics and Diagnostics
- Pharmaceutical Economics and Policy
- vaccines and immunoinformatics approaches
- Physical Activity and Health
- Lung Cancer Research Studies
- Economic and Financial Impacts of Cancer
- Diabetes Management and Education
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Function and Risk Factors
- Lung Cancer Diagnosis and Treatment
- Nutritional Studies and Diet
- Mobile Health and mHealth Applications
- Cardiovascular Health and Risk Factors
- Obesity, Physical Activity, Diet
- Global Maternal and Child Health
- Cardiovascular Health and Disease Prevention
- HIV, Drug Use, Sexual Risk
- Research on Leishmaniasis Studies
- Colorectal Cancer Screening and Detection
- Metabolomics and Mass Spectrometry Studies
Texas Children's Hospital
2021-2025
Behavioral Tech Research, Inc.
2024-2025
Wenzhou Medical University
2021-2025
First Affiliated Hospital of Wenzhou Medical University
2024-2025
Jiangnan University
2025
University of Washington
2019-2025
Huashan Hospital
2024-2025
Fudan University
2024-2025
State Key Laboratory of Respiratory Disease
2021-2025
Baylor College of Medicine
2021-2025
Abstract Aims To investigate the joint association of accelerometer-measured physical activity (PA) and sleep duration with mortality risk. Methods results A 7-day accelerometer recording was performed on 92 221 participants (age 62.4 ± 7.8 years; 56.4% women) from UK Biobank between February 2013 December 2015. We divided into three groups (short, normal, long), total volume PA levels according to tertiles (high, intermediate, low), moderate-to-vigorous (MVPA) two based World Health...
Neuronal accumulation and spread of pathological α-synuclein (α-syn) fibrils are key events in Parkinson's disease (PD) pathophysiology. However, the neuronal mechanisms underlying uptake α-syn remain unclear. In this work, we identified FAM171A2 as a PD risk gene that affects aggregation. Overexpressing promotes fibril endocytosis exacerbates neurotoxicity pathology. Neuronal-specific knockdown expression shows protective effects. Mechanistically, extracellular domain 1 interacts with C...
Abstract STING, an endoplasmic reticulum (ER) transmembrane protein, mediates innate immune activation upon cGAMP stimulation and is degraded through autophagy. Here, we report that activated STING could be transferred between cells to promote antitumor immunity, a process triggered by RAB22A-mediated non-canonical Mechanistically, RAB22A engages PI4K2A generate PI4P recruits the Atg12–Atg5–Atg16L1 complex, inducing formation of ER-derived autophagosome, in which agonists or...
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The aim of the current study was to investigate association accelerometer-measured sleep duration and different intensities physical activity (PA) with risk incident type 2 diabetes in a population-based prospective cohort study. Altogether, 88,000 participants (mean age = 62.2 ± 7.9 years, mean SD) were included from UK Biobank. Sleep (short: <6 h/day; normal: 6–8 long: >8 h/day) PA measured using wrist-worn accelerometer over 7-day period between 2013 2015. classified according median or...
The purpose of this study was to conduct a preliminary assess knowledge, attitude, and practice (KAP) associated with antibiotic use among medical students (MS) non-medical (NMS) at Kathmandu University, Nepal. A self-administered questionnaire distributed 1223 for cross-sectional study. In total, 1222 questionnaires collected from 609 MS 613 NMS were regarded as effective. t-test Chi-square test applied analyze the data. total 25 out 39 questions in KAP survey found have statistical...
SARS-CoV-2 protein subunit vaccines are currently being evaluated by multiple manufacturers to address the global vaccine equity gap, and need for low-cost, easy scale, safe, effective COVID-19 vaccines. In this paper, we report on generation of receptor-binding domain RBD203-N1 yeast expression construct, which produces a recombinant capable eliciting robust immune response protection in mice against challenge infections. The antigen was expressed Pichia pastoris X33. After fermentation at...
Introduction The development of a yeast-expressed recombinant protein-based vaccine technology co-developed with LMIC producers and suitable as COVID-19 for global access is described. proof-of-concept developing SARS-CoV-2 spike protein receptor-binding domain (RBD) antigen yeast-derived described.Areas Covered Genetic Engineering: strategy presented the design genetic modification used during cloning expression in yeast system. Process Assay Development: A summary how scalable,...
Abstract Background Both sleep duration and efficiency are essential for health outcomes. However, few studies have considered the effects of both on predicting risks mortality. This study investigated independent joint associations accelerometer-measured with all-cause cause-specific Methods The UK Biobank is a cohort over 500 000 individuals recruited between 2006 2010. included participants wearing wrist accelerometers 7 consecutive days February 2013 December 2015. Mortality was...
Tc24 is a Trypanosoma cruzi-derived flagellar protein that, when formulated with TLR-4 agonist adjuvant, induces balanced immune response in mice, elevating IgG2a antibody titers and IFN-γ levels. Furthermore, vaccination the recombinant can reduce parasite levels improve survival during acute infection. Although some mRNA vaccines have been proven to elicit stronger than vaccines, they not used against T. cruzi. This work evaluates immunogenicity of heterologous prime/boost regimen using...
Centralizing procurement for prescription drugs has the potential to reduce drug spending by creating economies of scale and improving purchasing power. In March 2019, Chinese government launched a volume-based (VBP) pilot program using competitive bidding process purchase accredited generic which branded substitutes were available. We performed an interrupted time-series design estimate change in monthly quantity comparing 14 months before 7 after VBP pilot. obtained data all purchases from...
BACKGROUND: Unhealthy lifestyle factors are risk for stroke, and they play a key role in stroke secondary prevention. A better understanding of these may aid with improvements public health policy. OBJECTIVE: Our objective was to comprehensively understand the trends unhealthy people who have previously had US. METHODS: Utilizing data from biannual United States National Health Nutrition Examination Surveys (NHANESs) between 1999 2018, we collated on (smoking, alcohol drinking, depression,...
To examine national trends in unhealthy lifestyle factors among adults with cardiovascular disease (CVD) the United States (US) between 1999 and 2018.We analyzed data from National Health Nutrition Examination Survey (NHANES), a nationally representative survey of participants CVD who were aged ≥20 years, which was conducted 2000 2017-2018. defined as self-report congestive heart failure, coronary disease, angina, attack, or stroke. The prevalence rate each factor calculated for 2-year cycle...
Thus far, the cellular and molecular mechanisms related to early (especially within 24 hours after acute myocardial infarct (MI)) exercise-mediated beneficial effects on MI have not yet been thoroughly established. In present study, we demonstrated that rats underwent moderate exercise training beginning one day showed no increase in mortality displayed significant improvements healing ventricular remodelling, including an improvement cardiac function, a decrease size, cardiomyocyte...
Bufei huoxue capsules (BFHX), manufactured products of traditional Chinese medicine, have demonstrated anti-inflammatory properties and efficacy against chronic pulmonary diseases COVID-19. This study was designed to further determine the clinical BFHX in diverse patient subgroups during convalescent phase COVID-19, extending upon previously reported findings from a multicenter randomized controlled trial. Patients who had clinically recovered COVID-19 were blindly assigned or placebo...
Introduction Pre-exposure prophylaxis (PrEP) is highly effective at preventing HIV acquisition, but coverage remains low in high prevalence settings. Initiating and continuing PrEP via online pharmacies a promising strategy to expand uptake little known about user preferences for this strategy. We describe methods discrete choice experiment (DCE) assess delivery from an pharmacy. Methods analysis This cross-sectional study conducted Nairobi, Kenya, partnership with MYDAWA, private pharmacy...
BACKGROUND: Hemophilia A (HA) is a rare, inherited, serious bleeding disorder characterized by deficiency of blood clotting factor VIII (FVIII). HA associated with considerable economic burden. OBJECTIVE: To identify, review, and summarize published studies on the health care resource use costs managing in United States using targeted literature review. METHODS: comprehensive search was conducted Embase, MEDLINE, Cochrane Database Systematic Reviews covering period 2010 to 2022. We...
ObjectivesTo explore the long-term trends in unhealthy lifestyle factors and risk sociodemographic subgroups among people with dyslipidemia.MethodsData extracted from 1999 to 2018 National Health Nutrition Examination Survey (NHANES). Lifestyle were smoking status, alcohol drinking, obesity, dietary quality, depression, physical activity, sedentary behavior. A Joinpoint regression model was used estimate log-transformed age-standardized prevalence. Multinomial logistic models adjusted for...
Abstract The development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses others currently exclusive bats, indicating epitope preservation individual antigens during...
ABSTRACT Purpose The present study aimed to compare the impacts of different exercise types on cardiovascular health and executive function in sedentary young individuals, determine associations between (EF) after exercise. Methods Sixty-three participants were randomly divided into high-intensity interval training (HIIT), moderate-intensity continuous (MICT), resistance (RE), control groups. Macro- microvascular endothelial assessed using brachial artery flow-mediated dilation fingertip...