A5089923491- SARS-CoV-2 and COVID-19 Research
- Research on Leishmaniasis Studies
- vaccines and immunoinformatics approaches
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Enzyme Structure and Function
- Advanced biosensing and bioanalysis techniques
- Vaccine Coverage and Hesitancy
- Animal Virus Infections Studies
- Biochemical and Molecular Research
- Bacteriophages and microbial interactions
- Amino Acid Enzymes and Metabolism
- Parasite Biology and Host Interactions
- Bacillus and Francisella bacterial research
- Biosensors and Analytical Detection
- RNA and protein synthesis mechanisms
- Viral gastroenteritis research and epidemiology
- COVID-19 epidemiological studies
- Advanced Biosensing Techniques and Applications
- Immunotherapy and Immune Responses
- Vector-borne infectious diseases
- Transgenic Plants and Applications
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Bacterial Genetics and Biotechnology
Texas Children's Hospital
2016-2025
Baylor College of Medicine
2016-2025
University of Houston
2009-2022
Children's Center
2020-2022
Center for Children
2021
Hospital for Tropical Diseases
2020
Sabin Vaccine Institute
2015-2017
Boston Children's Hospital
2015
University of South Carolina Sumter
2008
Texas A&M University
2005
Objective: To understand the correlates of COVID-19 vaccine hesitancy in American public and reasons why individuals intend to refuse a vaccine. Rationale: Recent polls suggest that significant share is reluctant receive an impending However, far less known about which Americans are most likely their for reluctance. Understanding these issues critical developing effective health communications improve vaccination end pandemic.Method: We rely on demographically representative survey 5,009...
Global deployment of vaccines that can provide protection across several age groups is still urgently needed to end the COVID-19 pandemic, especially in low- and middle-income countries. Although against SARS-CoV-2 based on mRNA adenoviral vector technologies have been rapidly developed, additional practical scalable are required meet global demand. Protein subunit formulated with appropriate adjuvants represent an approach address this urgent need. The receptor binding domain (RBD) a key...
Abstract Background Long COVID, which affects an estimated 44.69-48.04 million people in the U.S., is ongoing public health concern that will continue to grow as SARS-CoV-2 continues spread. Methods We developed a computational simulation model representing clinical course, effects, and associated costs of person with COVID. Results Simulations show average total cost COVID case can range from $5,084-$11,646 (assuming symptoms only last 1 year) 92.5%-95.2% these being productivity losses....
NPG disks as novel plasmonic nanoparticles greatly promote plasmon-matter interactions.
Antigen identification is an important step in the vaccine development process. Computational approaches including deep learning systems can play role of targets using genomic and proteomic information. Here, we present a new computational system to discover analyse novel leading design multi-epitope subunit candidate. The incorporates reverse vaccinology immuno-informatics tools screen datasets several pathogens such as Trypanosoma cruzi, Plasmodium falciparum, Vibrio cholerae identify...
There is an urgent need for accessible and low-cost COVID-19 vaccine suitable low- middle-income countries. Here, we report on the development of a SARS-CoV-2 receptor-binding domain (RBD) protein, expressed at high levels in yeast (Pichia pastoris), as candidate against COVID-19. After introducing two modifications into wild-type RBD gene to reduce yeast-derived hyperglycosylation improve stability during protein expression, show that recombinant RBD219-N1C1, equivalent (RBD219-WT) vitro...
Ongoing SARS-CoV-2 vaccine development is focused on identifying stable, cost-effective, and accessible candidates for global use, specifically in low middle-income countries. Here, we report the efficacy of a rapidly scalable, novel yeast expressed specific receptor-binding domain (RBD) based rhesus macaques. We formulated RBD immunogen alum, licensed an emerging alum adsorbed TLR-7/8 targeted, 3M-052-alum adjuvants. The RBD+3M-052-alum adjuvanted promoted better binding effector...
Face mask wearing has been an important part of the response to COVID-19 pandemic. As vaccination coverage progresses in countries, relaxation such practices is increasing. Subsequent surges have raised questions whether face masks should be encouraged or required and for how long. Here, we aim assess value maintaining use indoors according different levels USA.
Introduction The development of a yeast-expressed recombinant protein-based vaccine technology co-developed with LMIC producers and suitable as COVID-19 for global access is described. proof-of-concept developing SARS-CoV-2 spike protein receptor-binding domain (RBD) antigen yeast-derived described.Areas Covered Genetic Engineering: strategy presented the design genetic modification used during cloning expression in yeast system. Process Assay Development: A summary how scalable,...
With efforts underway to develop a universal coronavirus vaccine, otherwise known as pan-coronavirus this is the time offer potential funders, researchers, and manufacturers guidance on value of such vaccine how may change with differing vaccination characteristics.
Chagas disease (CD) (American trypanosomiasis caused by Trypanosoma cruzi) is a parasitic endemic in 21 countries South America, with increasing global spread. When administered late the infection, current antiparasitic drugs do not prevent onset of cardiac illness leading to chronic Chagasic cardiomyopathy. Therefore, new therapeutic vaccines or immunotherapies are under development using multiple platforms. In this study, we assessed feasibility developing an mRNA-based CD vaccine...
We present label-free,<italic>in situ</italic>monitoring of individual DNA hybridization in microfluidics.