A5087170372- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- HIV/AIDS Research and Interventions
- Long-Term Effects of COVID-19
- Neuroendocrine regulation and behavior
- Bone Tumor Diagnosis and Treatments
- Cancer Immunotherapy and Biomarkers
- Lysosomal Storage Disorders Research
- Advanced biosensing and bioanalysis techniques
- Glycogen Storage Diseases and Myoclonus
- interferon and immune responses
- Infant Health and Development
- Immune Cell Function and Interaction
- bioluminescence and chemiluminescence research
- Biosensors and Analytical Detection
- Adipokines, Inflammation, and Metabolic Diseases
- Animal testing and alternatives
- HIV-related health complications and treatments
- Anesthesia and Neurotoxicity Research
- Advanced Biosensing Techniques and Applications
- Education and Critical Thinking Development
- Inflammasome and immune disorders
- Reproductive tract infections research
Emory University
2014-2023
Ongoing SARS-CoV-2 vaccine development is focused on identifying stable, cost-effective, and accessible candidates for global use, specifically in low middle-income countries. Here, we report the efficacy of a rapidly scalable, novel yeast expressed specific receptor-binding domain (RBD) based rhesus macaques. We formulated RBD immunogen alum, licensed an emerging alum adsorbed TLR-7/8 targeted, 3M-052-alum adjuvants. The RBD+3M-052-alum adjuvanted promoted better binding effector...
Type I interferons (IFN-I) are critical mediators of innate control viral infections but also drive the recruitment inflammatory cells to sites infection, a key feature severe coronavirus disease 2019. Here, IFN-I signaling was modulated in rhesus macaques (RMs) before and during acute SARS-CoV-2 (severe respiratory syndrome 2) infection using mutated IFN-α2 (IFN-modulator; IFNmod), which has previously been shown reduce binding endogenous IFN-I. IFNmod treatment uninfected RMs observed...
Nonhuman primates with long-term cranial implant chambers require regular chamber cleaning antiseptic solutions. The purpose of this study was to determine if ATP bioluminescence testing can be used identify microbial contamination fomites and environmental samples in the context procedures. bioluminescent swab were compared traditional bacterial culture from same sources collected during scheduled maintenance procedures for Rhesus macaques ( Macaca mulatta ) that are part studies related...
Understanding viral rebound in pediatric HIV-1 infection may inform the development of alternatives to lifelong antiretroviral therapy (ART) achieve remission. We thus investigated after analytical treatment interruption (ATI) 10 infant macaques orally infected with SHIV.C.CH505 and treated long-term ART. Rebound viremia was detected within 7 35 days ATI 9 animals, posttreatment control seen 5 Mamu-A*01+ macaques. Single-genome sequencing revealed that initial virus similar DNA present CD4+...
Abstract Type-I interferons (IFN-I) are critical mediators of innate control viral infections, but also drive recruitment inflammatory cells to sites infection, a key feature severe COVID-19. Here, and for the first time, IFN-I signaling was modulated in rhesus macaques (RMs) prior during acute SARS-CoV-2 infection using mutated IFNα2 (IFN-modulator; IFNmod), which has previously been shown reduce binding endogenous IFN-I. In SARS-CoV-2-infected RMs, IFNmod reduced both antiviral ISGs....
Abstract Background Rhesus and cynomologus macaques are valuable animal models for the study of human immunodeficiency virus ( HIV ) prevention strategies. However, such studies focused on vaginal route infection, differences in environment may have deterministic impact outcome prevention, providing rationale this study. Methods We tested rhesus cynomolgus longitudinally to characterize normal microflora based Nugent scores pH . This evaluation was extended after colonization space with...
Effective therapeutics aimed at mitigating COVID-19 symptoms are urgently needed. SARS-CoV-2 induced hypercytokinemia and systemic inflammation associated with disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor potent anti-inflammatory properties is currently being investigated in human clinical trials. Recent reports suggest that baricitinib may also have antiviral activity limiting viral endocytosis. Here, we the immunologic virologic efficacy of rhesus macaque model...
A 57‐year‐old female chimpanzee presented with a brief history of increasing lethargy and rapidly progressive lower‐limb weakness that culminated in loss use. Postmortem examination revealed no significant gross lesions the nervous system or other organ systems. Histological analysis round, basophilic to amphophilic polyglucosan bodies (PGBs) white gray matter cervical, thoracic, lumbar, coccygeal regions spinal cord. Only rare PGBs were observed forebrain samples. The cord polymorphic, they...