A5100759066- Cardiovascular Disease and Adiposity
- Hormonal Regulation and Hypertension
- Nitric Oxide and Endothelin Effects
- Blood Pressure and Hypertension Studies
- Renin-Angiotensin System Studies
- Bone and Dental Protein Studies
- Cardiovascular Health and Disease Prevention
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ion channel regulation and function
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- Protein Kinase Regulation and GTPase Signaling
- Apelin-related biomedical research
- Neurobiology and Insect Physiology Research
- Receptor Mechanisms and Signaling
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Adrenal and Paraganglionic Tumors
- Biomarkers in Disease Mechanisms
- Pharmacogenetics and Drug Metabolism
- Sodium Intake and Health
- Cardiac and Coronary Surgery Techniques
- Cancer, Lipids, and Metabolism
- Bone Metabolism and Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
Ruijin Hospital
2013-2024
Shanghai Institute of Hypertension
2013-2024
Shanghai Jiao Tong University
2010-2021
Shanghai Institutes for Biological Sciences
2007-2016
Chinese Academy of Sciences
2005-2016
Shanghai Medical College of Fudan University
2015
University of Rochester
2015
State Key Laboratory of Medical Genomics
2007-2010
Shanghai Institute of Hematology
2005-2010
Center for Vascular Biology Research
2009
Recent studies have shown that somatic mutations in the KCNJ5, ATP1A1, ATP2B3, and CACNA1D genes are associated with pathogenesis of aldosterone-producing adenoma. Clinical profile biochemical characteristics Chinese patients adenoma remain unclear. In this study, we performed DNA sequencing 168 found 129 4 1 CACNA1D. KCNJ5 were more prevalent female larger adenomas, higher aldosterone excretion, lower minimal serum K + concentration. More interestingly, identified a novel mutation...
Abstract Aging is an independent risk factor for vascular diseases. Perivascular adipose tissue (PVAT), active component of the vasculature, contributes to dysfunction during aging. Identification underlying cell types and their changes aging may provide meaningful insights regarding clinical relevance aging‐related Here, we take advantage single‐cell RNA sequence characterize resident stromal cells in PVAT (PVASCs) identified different clusters between young aged PVASCs. Bioinformatics...
To examine the role of perivascular adipose tissue (PVAT)-derived factors in regulation adventitial fibroblast (AF) function vitro and vivo.PVAT is an active component blood vessels. Bioactive substances released from PVAT play regulatory roles vascular function. However, their effects on AFs remain unclear. PVAT-conditioned medium stimulated AF migration using a transwell technique, differentiation was evaluated by α-smooth muscle-actin induction. We identified secretome liquid...
Objective— We have previously shown an increased expression of complement 3 (C3) in the perivascular adipose tissue (PVAT) deoxycorticosterone acetate (DOCA)–salt hypertensive model. This study aims to examine role and underlying mechanism C3 PVAT for understanding pathogenesis vascular remodeling further. Approach Results— The macrophage polarization was investigated using peritoneal macrophages from wild-type C3-deficient (C3KO) mice because we found that primarily expressed blood vessels...
Abstract Vascular calcification (VC) is a highly regulated ectopic mineral deposition process involving immune cell infiltration in the vasculatures, which has been recognized to be promoted by hypertension. The matricellular glycoprotein osteopontin (OPN) strongly induced myeloid cells as potential inflammatory mediator of vascular injury. This study aims examine whether OPN involved regulation macrophage activation and osteoclast formation hypertensive subjects with VC. We firstly found an...
The renin-angiotensin system (RAS) has been implicated in atherosclerotic lesions and progression to chronic kidney diseases. We examined regulatory roles of angiotensin-converting enzyme 2 (ACE2) the apolipoprotein E (ApoE) knockout (KO) kidneys.The 3-month-old wild-type, ApoEKO, ACE2KO ApoE/ACE2 double-KO (DKO) mice a C57BL/6 background were used. ApoEKO randomized daily deliver either Ang II (1.5 mg/kg) and/or human recombinant ACE2 (rhACE2; for weeks. changes pro-inflammatory cytokines,...
Atherosclerosis, like several other vascular diseases, exhibits structural and functional abnormalities resulting partially from an exaggerated proliferation of smooth-muscle cells (VSMCs). Ca2+ channel blockers, such as amlodipine, have been suggested to retard or even prevent the progression atherosclerosis. To determine mechanisms involved in these effects, we investigated influence amlodipine on VSMC by using rat aortic VSMCs culture. Amlodipine (0.1-10 μM) inhibited serum-, basic...
Summary Objective Evidence from animal models and human studies suggests that CYP2J2 plays a mechanistic role in the development of hypertension. The present study aims to investigate potential genetic contribution gene etiology essential hypertension (EH) individual blood pressure. Methods We selected eight polymorphisms in/or around performed case‐control association involving 841 Han Chinese subjects, including 415 unrelated hypertensives 426 age‐, gender‐ area‐matched normotensives....
Angiotensin-converting enzyme 2 (ACE2), a monocarboxypeptidase which metabolizes angiotensin II (Ang II) to generate Ang-(1-7), has been shown prevent cardiac hypertrophy and injury but the mechanism remains elusive. Irbesartan dual actions of receptor blockade peroxisome proliferator-activated receptor-γ (PPARγ) activation. We hypothesized that irbesartan would exert its protective effects on ACE2 deficiency-mediated myocardial fibrosis via PPARγ signaling.10-week-old knockout (ACE2KO;...
In our series of patients with primary aldosteronism, we compared diagnostic concordance and clinical outcomes after adrenalectomy between adrenal venous sampling (AVS) computed tomography (CT) imaging. Our retrospective analysis included 886 aldosteronism diagnosed in hospital 2005 2014. Of them, 269 CT unilateral disease were the on 126 follow-up data adrenalectomy. Hypertension was considered cured if systolic/diastolic blood pressure (BP) controlled (<140/90 mm Hg) without medication...
A positive association between inflammation and chronic kidney disease (CKD) has been reported but the impact of hypertension on this relation remains unclear. The aim study is to investigate various markers with risk CKD in hypertensive patients. 387 patients (mean age 55.5 years) were recruited. Serum matrix metalloproteinase-2 (MMP-2), metalloproteinase-9 (MMP-9), tissue inhibitor metalloproteinase-1(TIMP-1), high-sensitivity C-reactive protein (hsCRP) osteopontin (OPN) measured by ELISA....
Background Most studies have suggested that elevated body mass index (BMI) was associated with the risk of death from all cause and specific causes. However, there little evidence illustrating effect BMI on mortality in elderly hypertensive patients Chinese population. Methods The information 10,957 at baseline not less than 60 years were Xinzhuang, a town Minhang district Shanghai, extracted Electronic Health Record (EHR) system. All study participants divided into eight categories (with...
Krüppel-like factor (KLF) 15 has emerged as a critical regulator of fibrosis in cardiovascular diseases. However, the precise role that KLF15 and its functional domain played adventitial inflammation remains unclear. This study aims to investigate transactivation (TAD) angiotensin II (Ang II)-induced pathologic changes. expression was decreased vascular adventitia Ang II-infused mice (1000 ng/kg/min, 14 d) fibroblasts (AFs) stimulated by (10-7 M). Adenovirus-mediated overexpression...
Beta3 adrenergic receptor (ADRB3) mediates vessel relaxation in the endothelium while it modulates lipolysis adipose tissue. However, function and regulation mechanism of ADRB3 perivascular tissue (PVAT), especially hypertension, is still unclear. We show that protein upregulated PVAT deoxycorticosterone acetate-salt (DOCA-salt) hypertensive mice, with characteristics browning increased uncoupling 1 (UCP1) expression. Inhibition selective antagonist SR59230A caused serious vascular injury...
Perivascular adipose tissue (PVAT)-derived adiponectin (APN) is a secreted adipokine that protects against hypertension-related cardiovascular injury. However, the regulation of APN expression in hypertension remains to be explored. In this study, we demonstrated down-regulation was associated with complement activation PVAT desoxycorticosterone acetate (DOCA)-salt hypertensive mice. Complement 3-deficient mice were protected from ANP decrease PVAT. deficiency blockaded protective effects...
Inherited predisposition to thrombosis contributes the initiation and progression of coronary artery disease (CAD). The present study was designed explore relationship between genetic variation coagulation factor V occurrence CAD. A total 141 unrelated patients with CAD 175 healthy controls were analyzed by polymerase chain reaction‐denaturing gradient gel electrophoresis (PCR‐DGGE) for detection in all 25 exons gene. Among subjects, 55 73 evaluated at random response activated protein C...