A5104023705- Nutrition, Genetics, and Disease
- Genetics and Neurodevelopmental Disorders
- Genetic and phenotypic traits in livestock
- Liver Disease Diagnosis and Treatment
- Milk Quality and Mastitis in Dairy Cows
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- Genetic Associations and Epidemiology
- Animal Genetics and Reproduction
- Diet, Metabolism, and Disease
- Genomics and Chromatin Dynamics
- Traumatic Brain Injury Research
- Child and Adolescent Psychosocial and Emotional Development
- Anorectal Disease Treatments and Outcomes
- Spine and Intervertebral Disc Pathology
- Genomics and Rare Diseases
- DNA Repair Mechanisms
- Hereditary Neurological Disorders
- Advanced Measurement and Detection Methods
- Regulation of Appetite and Obesity
- Animal Diversity and Health Studies
- interferon and immune responses
- Spondyloarthritis Studies and Treatments
- Pharmacogenetics and Drug Metabolism
- RNA and protein synthesis mechanisms
Central South University
2010-2024
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2024
Second Xiangya Hospital of Central South University
2024
University of Virginia
2024
Southeast University
2023
Tianjin Medical University
2023
Beijing Chao-Yang Hospital
2020
Capital Medical University
2020
West China Second University Hospital of Sichuan University
2018
People's Hospital of Xinjiang Uygur Autonomous Region
2017
Bovine mastitis is a typical inflammatory disease causing seriously economic loss. Genome-wide association study (GWAS) can be powerful method to promote marker assistant selection of this kind complex disease. The present aimed analyze and identify single nucleotide polymorphisms (SNPs) candidate genes that associated with susceptibility traits in Chinese Holstein.Forty eight SNPs were identified significantly resistance Holstein cows, which are mainly located on the BTA 14. A total 41...
Summary Objective Evidence from animal models and human studies suggests that CYP2J2 plays a mechanistic role in the development of hypertension. The present study aims to investigate potential genetic contribution gene etiology essential hypertension (EH) individual blood pressure. Methods We selected eight polymorphisms in/or around performed case‐control association involving 841 Han Chinese subjects, including 415 unrelated hypertensives 426 age‐, gender‐ area‐matched normotensives....
Background Amantadine is currently recommended for use in patients of post-traumatic brain injury with unresponsive wakefulness syndrome (UWS). However, the application amantadine UWS after cerebral hemorrhage has only been rarely reported. This allows a further exploration role treatment resulting from severe hemorrhage.Methods We observed changes seven intracerebral taking amantadine. also carried out detailed neurological examination patient disorders consciousness to include or exclude...
Patt1 is a newly identified protein acetyltransferase that highly expressed in liver. However, the role of liver still unclear. We generated liver-specific knockout (LKO) mice and mainly measured effect hepatic deficiency on lipid metabolism. Hepatic male markedly decreases fat mass dramatically alleviates age-associated accumulation droplets Moreover, abrogation significantly reduces triglyceride free fatty acid levels, but it has no cholesterol level, weight, function. Consistently,...
Abstract BACKGROUND Hirschsprung disease (HSCR) is a congenital disorder characterized by an absence of intrinsic ganglion cells in the nerve plexuses lower colon. Our previous results showed increased semaphorin 3A ( SEMA3A ) expression may be risk factor for HSCR pathology subset patients. Therefore, association between polymorphisms and was examined. METHODS The genotypes two SNPs (rs7804122 rs797821) gene 119 patients with 93 controls were examined using PCR‐sequencing to determine...
The ATP-binding cassette G2 (ABCG2), a drug transporter gene, mainly has xenotoxin protective function. Xenotoxins are transferred from the mother to suckling infant via milk that is difficult reconcile with role. ABCG2 located within linkage region Quantitative Trait Locus (QTL) for production and content resulting it represents functional candidate gene association traits in dairy cattle. In present study, we investigated polymorphism of using pooled DNA sequencing, as result, single...
The Interferon-induced protein with tetratricopeptide repeat (IFIT) family, IFIT1/2/3/5, play an important role in different tumors progression. However, the prognosis significance and biological of IFIT family members acute myeloid leukemia (AML) remains unclear.We obtained gene expression data clinical information 173 AML patients from Cancer Genome Atlas (TCGA) database. Several databases were used our study, including GEPIA, MethSurv, STRING, GSCA GeneMANIA database.The mRNA IFIT1/2/3/5...
Abstract Phase separation serves an important role in the three-dimensional chromosome organization and remodeling eukaryotes. Whether this process is involved archaeal unknown. Here we demonstrate that DNA condensing protein1 (aDCP1) from hyperthermophilic crenarchaeon Sulfolobus islandicus able to bridge efficiently form large protein-DNA condensates with a droplet- or gel-like morphology vitro . Within condensates, aDCP1 exhibits fast dynamic while appears solid-like state. At...
Study Design Retrospective cohort study. Objectives Patients with IBD are at an increased risk for postoperative complications following surgery. The goal of this study is to investigate if inflammatory bowel disease (IBD) a factor lumbar discectomy. Methods We identified patients who underwent discectomy disc herniation (LDH) and matched them controls without in a1:5 ratio. excluded history spinal injury, cancer, infection, trauma, or surgery remove the digestive tract. used multivariate...
To study the polymorphisms of human platelet antigen (HPA) 1-16 and leukocyte (HLA)-A -B loci among ethnic Han population from Shandong.A total 588 samples donors were genotyped for above with sequence-specific primer PCR oligonucleotide probe PCR.The frequencies HPA-la, -1b, HPA-2a, -2b, HPA-3a, -3b, HPA-4a, -4b, HPA-5a, -5b, HPA-6a, -6b, HPA-15a, -15b 0.9974, 0.0026, 0.9456, 0.0544, 0.5417, 0.4583, 0.9983, 0.0017, 0.9889, 0.0111, 0.9903, 0.0097, 0.5434 respectively. The HPA-7-14 HPA-16...
Objective To explore the association between impulsively aggressive behavior and rs6922753 single nucleotide polymorphism of glutamate receptor 6 (GluR6) gene in Xinjiang Uygur Han patients with bipolar disorder. Methods The techniques polymerase chain reaction (PCR) DNA sequencing technique were conducted to detect GluR6 240 disorder. The polymorphisms was analyzed SPSS 17.0 software. Results No statistical difference observed group no disorder genotype allele frequencies for...
To investigate the association between breast tissue specified variants in p53 binding sites and risk of BC Chinese women.ChIP-seq database on MCF-7 cell lines was extracted to identify possible target genes. A hospital-based case-control study then performed a women population.Three were identified from bioinformatics analysis. total 1 274 cases 255 frequency-matched cancer-free controls included this study. The average age comparable case control groups, with P value as 0.318. Meanwhile,...
To report on a novel HLA-A allele, A*29:49, identified in Chinese Han population by sequence based typing (SBT).A donor from China Marrow Donor Programme (CMDP) was typed with bi-allelic PCR-SBT kit, and no full matched result obtained for the locus. The HLA allele verified an allele-specific amplification SBT kit.A identified, which has differed one nucleotide closest HLA-A*29:01:01:01, at position 368(A→T), codon 99 (TAT→TTT), resulting amino acid substitution (Y→F). Another as...