A5001612078- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Nutrition and Health in Aging
- Viral Infectious Diseases and Gene Expression in Insects
- Renal Diseases and Glomerulopathies
- Iron Metabolism and Disorders
- Gout, Hyperuricemia, Uric Acid
- Tryptophan and brain disorders
- Acute Kidney Injury Research
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Insect Resistance and Genetics
- RNA Interference and Gene Delivery
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Cancer Research and Treatments
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Diet and metabolism studies
- Traditional Chinese Medicine Studies
Hubei University of Chinese Medicine
2019-2025
First Affiliated Hospital of Henan University
2023-2025
Jinan University
2016-2025
McDermott International (United States)
2025
China Medical University
2025
First Hospital of China Medical University
2025
Red Cross Hospital
2003-2025
Weifang People's Hospital
2021-2025
Shanghai Jiao Tong University
2012-2024
Guiyang Medical University
2024
Noble decoration: DNA origami nanostructures (purple) were utilized as spatially addressable templates to organize noble-metal nanoparticles of silver (yellow balls) and gold (red ball) into well-defined discrete architectures (see examples nanostructure designs TEM images the assembled structures).
Abstract Neuroinflammation, for which microglia are the predominant contributors, is a significant risk factor cognitive dysfunction. Riboflavin (also known as vitamin B2) ameliorates impairment via anti‐oxidative stress and anti‐inflammation properties; however, underlying mechanisms linking riboflavin metabolism microglial function in remain unclear. Here, it demonstrated that kinase (RFK), critical enzyme metabolism, specifically expressed microglia. An intermediate product of riboflavin,...
Mimicking nature is both a key goal and difficult challenge for the scientific enterprise. DNA, well known as genetic-information carrier in nature, can be replicated efficiently living cells. Today, despite dramatic evolution of DNA nanotechnology, versatile method that replicates artificial nanostructures with complex secondary structures remains an appealing target. Previous success replicating enzymatically vitro suggests possible solution could cloning these by using viruses. Here, we...
Objective(s)To explore the validity of using bioelectrical impedance analysis (BIA)-derived 50 kHz phase angle (PhA) in predicting protein–energy wasting (PEW) Chinese maintenance hemodialysis (MHD) patients.Design and MethodsThe design was a cross-sectional study. A total 173 MHD patients healthy adults were enrolled The prevalence PEW performed by International Society Renal Nutrition Metabolism criteria. PhA, body cell mass, fat percentage, fat-free extracellular water/total water...
Abstract Background Chronic kidney disease (CKD) affects gut flora by causing dysbiosis and lead to systemic inflammatory conditions. Here, we provide intestinal changes of CKD patients undertook different hemodialysis therapy. Methods From 2017 2019, a total 166 from Guangzhou Red Cross Hospital were recruited divided into four groups with 17 cases in healthy control group, 47 non-dialysis 49 HD 53 PD group. Intestinal genome 16S rDNA sequencing further bio-informatic analysis performed....
Diabetic kidney disease (DKD) is a severe complication of type 2 diabetes mellitus (T2DM). However, the pathogenesis DKD remains unclear, and effective treatment strategies are still lacking. Ginsenoside Rg1 (Rg1) has been reported to improve DKD, but mechanism unclear. NADPH oxidase 4 (NOX4) an essential reactive oxygen species (ROS) source in kidney. The mitogen-activated protein kinase (MAPK) signaling may exacerbate renal fibrosis. Therefore, we hypothesized that might alleviate injury...
Acute liver injury (ALI) is a common clinical disease caused by sepsis, metabolic syndrome, hepatitis virus. Macrophage plays an important role in the development of ALI, which characterized polarization and inflammatory regulation. The process macrophages related to membrane binding proteins adaptors. Protein 4.1R acts as adaptor, linking cytoskeleton, involved cell activation cytokine secretion. However, whether protein regulating macrophage inflammation-induced remains unknown. In this...
A role for serotonin in male sexual preference was recently uncovered by our finding that mutant mice lacking have lost preference. Here we show female mouse mutants either central serotonergic neurons or prefer over genital odors when given a choice, and displayed increased female–female mounting presented with choice of target only target. Pharmacological manipulations genetic rescue experiments showed is required adults. Behavioral changes caused deficient signaling were not due to plasma...
We evaluated the correlation between oral health-related quality of life (OHRQoL) and Helkimo clinical dysfunction index (HDI) in patients with temporomandibular joint osteoarthritis (TMJ OA). Clinical data scores for Chinese version 14-item Oral Health Impact Profile (OHIP-C14) were recorded analyzed 541 TMJ OA. Each patient was assigned an HDI score 1 to 25, which used classify severity into three categories. OHRQoL assessed by using OHIP-C14 score, ranged from 0 56. Both significantly...
Abstract Background The single-pool model urea clearance index (single-pool Kt/V ; spKt/V) is the most commonly used method for dialysis adequacy assessment. However, only a few studies have examined relationship between spKt/V values and parameters related to sarcopenia nutritional status. This study aimed evaluate whether an indicator of status in patients undergoing maintenance hemodialysis (MHD). Methods A total 142 were included this single-center, cross-sectional study. Venous blood...
Prolonged elevation of serum aldosterone leads to renal fibrosis. Inflammation also plays a role in the pathogenesis disease. We used rat model interstitial fibrosis test hypothesis that eplerenone-mediated blockade prevents due its anti-inflammatory and anti-proliferative effects.Eplerenone (a selective blocker) or vehicle (control), was given male Wistar rats (50 mg/kg, twice daily) for 7 days before unilateral ureteral obstruction (UUO) an additional 28 after surgery. Body weight, blood...
BACKGROUND The acceptances and long-term outcomes of the renal transplantations are seriously jeopardized by inflammatory responses damage to tissues. present study intended explicate pharmacological effect luteolin (LT) in ischemia/reperfusion (I/R) injury possible mechanism action LT. MATERIAL AND METHODS LT on level interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α homogenates kidney tissues male Swiss albino mice was determined after I/R injury. MDA (malondialdehyde), SOD...
Abstract Metformin has been demonstrated to prevent hepatocellular carcinoma (HCC). acts mainly by phosphorylation of AMPK. However, the status AMPK and its role in prediction prevention HCC cirrhotic patients remains unclear. The (Thr172) was determined immunostaining tissue microarrays 426 liver tissues. Low expression p-AMPK observed 94 (22.1%) cases. median follow-up time 87 months. occurrence probability at 1/3/5/10 years after Hassab procedure 3.1/9.6/13.8/30.6% with low 0/0.3/0.3/8%...
Statins may decrease chronic kidney diseases (CKDs) risk, but their underlying molecular mechanisms are not completely understood. Recent studies indicate Endothelial-to-mesenchymal transition (EndMT) plays an important role contributing to renal interstitial fibrosis. In the present study, we first investigated whether lovastatin could ameliorate fibrosis via suppression of EndMT and its possible mechanism. vitro experiments, significantly ameliorated microalbuminuria pathologic changes in...
Chronic kidney disease (CKD) increases cardiovascular (CVD) risk. However, the association of mildly reduced function with CVD risk is unclear.This study investigated estimated glomerular filtration rate (eGFR) prevalent CVDs, 10-year Framingham for coronary heart (CHD), and atherosclerotic diseases (ASCVD) in 239 832 participants from baseline Risk Evaluation cAncers Chinese diabeTic Individuals: a lONgitudinal study. With an interviewer-assisted questionnaire, we collected information on...