A5101885936- Fungal Biology and Applications
- Spectroscopy and Chemometric Analyses
- Advanced Drug Delivery Systems
- Enzyme Production and Characterization
- Medicinal Plants and Bioactive Compounds
- Water Quality Monitoring and Analysis
- RNA Interference and Gene Delivery
- Biofuel production and bioconversion
- Polysaccharides and Plant Cell Walls
- Microbial Metabolic Engineering and Bioproduction
- Tryptophan and brain disorders
- Advanced biosensing and bioanalysis techniques
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Nanoparticle-Based Drug Delivery
- Analytical Chemistry and Chromatography
- Microbial Metabolites in Food Biotechnology
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Chromatography in Natural Products
- Food Quality and Safety Studies
- Drug Solubulity and Delivery Systems
Jilin University
2014-2023
Jilin Medical University
2010-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Zhuhai Institute of Advanced Technology
2012
Yanbian University
2010
Changchun University
2009
First Hospital of Jilin University
2008
Abstract The recent success of mRNA therapeutics against pathogenic infections has increased interest in their use for other human diseases including cancer. However, the precise delivery genetic cargo to cells and tissues remains challenging. Here, we show an adaptive strategy that enables docking different targeting ligands onto surface mRNA-loaded small extracellular vesicles (sEVs). This is achieved by using a microfluidic electroporation approach which combination nano- milli-second...
Due to substantial morbidity and high complications, diabetes mellitus is considered as the third "killer" in world. A search for alternative antidiabetic drugs from herbs or fungi highly demanded. Our present study aims investigate activities of Cordyceps militaris on diet-streptozotocin-induced type 2 rats. Diabetic rats were orally administered with water extract alcohol at 0.05 g/kg 3 weeks, then, factors levels related blood glucose, lipid, free radicals, even nephropathy determined....
Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer Na Qu,1 Robert J Lee,1,2 Yating Sun,1 Guangsheng Cai,1 Junyang Wang,1 Mengqiao Jiahui Lu,1 Qingfan Meng,1 Lirong Teng,1 Di Lesheng Teng1,3 1School of Life Sciences, Jilin University, Changchun, People's Republic China; 2Division Pharmaceutics, College Pharmacy, The Ohio State Columbus, OH, USA; 3State Key Laboratory Long-acting and Targeting Drug Delivery System, Yantai, China Abstract:...
This study evaluated the effects of Inonotus obliquus polysaccharides (IOs) on diabetes and other underlying mechanisms related to inflammatory factors oxidative stress in a mouse model streptozotocin (STZ)-induced diabetes. Four weeks administration metformin (120 mg/kg) IO1-4 (50%-80% alcohol precipitation), or IO5 (total 80% precipitation) at doses 50 mg/kg reverses abnormal changes bodyweights fasting blood glucose levels diabetic mice. IOs significantly increased insulin pyruvate kinase...
It is always a challenge to determine the total cellulase activity efficiently without reducing accuracy. The most common assay filter paper (FPA) established by International Union of Pure and Applied Chemistry (IUPAC). A new procedure measure FPA with microplate-based was studied in this work, which followed main idea IUPAC dilute preparation get fixed glucose release. FPAs six preparations were determined assay. shown that Youtell, RCconc, R-10, Lerkam, Yishui Sinopharm 67.9, 46.0, 46.1,...
Sarcodon imbricatus (SI), a precious edible fungus, contains 35.22% of total sugar, 18.33% protein, 24 types fatty acid, 16 amino and 8 minerals. Encouragingly, it is rich in potential antioxidants such as polyphenols (0.41%), sterols (3.16%), vitamins (0.44%). In the present study, antifatigue properties SI its mechanisms action were explored by experiments on acute excise‐treated mice chronic fatigue syndrome (CFS) mice. (0.25, 0.5, 1 g/kg) significantly enhanced exercise tolerance...
Purpose: Methotrexate (MTX) is a first-line drug for rheumatoid arthritis (RA)therapy.However, MTX monotherapy often results in irreversible joint damage due to its slow onset of action and long duration.microRNA-124 (miR-124) has shown direct bone protection activity against RA.A co-delivery system microRNA combination may provide therapeutic synergy.Methods: Methotrexate-conjugated polymer hybrid micelles (M-PHMs) were prepared by self-assembly two functional amphiphilic polymers...
Obesity is characterized by massive fat deposition and related to a series of metabolic complications, such as insulin resistance (IR) steatohepatitis. Grifola frondosa (GF) basidiomycete fungus source various nutritional ingredients human health. In this study, after systematic analysis its ingredients, GF was administered mice fed high-fat diet (HFD) investigate effects on lipid metabolism. HFD-fed mice, significantly controlled the body weight, blood glucose organ indices, effectively...
Obesity is frequently associated with dysregulated lipid metabolism and lipotoxicity. Inonotus hispidus (Bull.: Fr.) P. Karst (IH) an edible medicinal parasitic mushroom. In this study, after a systematic analysis of its nutritional ingredients, the regulatory effects IH on were investigated in mice fed high-fat diet (HFD). HFD-fed mice, reversed pathological state liver three types fat significantly decreased levels low-density lipoprotein cholesterol (LDL-C), total (TC), triglycerides...
A 4-week sustained release risperidone biodegradable poly(D,L-lactide-co-glycolide) (PLGA) microsphere for the therapy of schizophrenia, effects formulation parameters on encapsulation efficiency and behavior were studied. The PLGA microspheres prepared by O/W solvent evaporation method characterized HPLC, SEM, laser particle size analysis, GC HPLC-MS. results indicated that morphology presented a spherical shape with smooth surface, was distributed from 32 to 92 μm drug influenced...
Salvianolic acid A (SAA), one of the major active components Danshen that is a traditional Chinese medicine, has been reported to possess protective effect in cardiac diseases and antioxidative activity. This study aims investigate cardioprotection SAA vivo vitro using model myocardial ischemia-reperfusion rat hydrogen peroxide (H(2)O(2))-induced H9c2 cardiomyoblasts apoptosis. It was found significantly limited infarct size ischemic myocardium when given immediately prior reperfusion. also...
In the present study, components of A. cinnamomea (AC) mycelia were systematically analyzed. Subsequently, its hepatoprotective effects and underlying mechanisms explored using a mouse model acute alcohol‐induced liver injury. AC contained 25 types fatty acid, 16 amino 3 nucleotide, 8 mineral. The observed after 2 weeks treatment at doses 75 mg/kg, 225 675 mg/kg in model. These indicated by changes levels aspartate aminotransferase, alanine several oxidation‐related factors, inflammatory...
Aims: Sarcodon imbricatus, an edible fungus, is widely used in Asian medicine because of its significant pharmacological activities. In the present study, we investigated immunomodulatory effects polysaccharide-enriched S. imbricatus extracts (SP) cyclophosphamide (CTX)-induced immunosuppressed mice. Results: Astragalus polysaccharide (AP) was as a positive control. Compared with CTX-induced mice, thirty-day SP treatment strongly enhanced organ indexes spleen and thymus suppressed hind paw...
Paecilomyces hepiali is a fungus widely used in Asian countries for various potential pharmacological activities. The present study aims to evaluate the antidiabetic and antinephritic effects of mycelium water extract (PHC) diabetic rat, which established by eight-week high-fat diet administration followed one-week tail intravenous injection 25 mg/kg streptozotocin (STZ). After four-week 0.12 g/kg metformin PHC at doses 0.08, 0.4, 2.0 treatment, an increment body weight, decrement plasma...
Abstract Background Mild cognitive impairment (MCI) is an intermediate stage between normal aging and dementia. Studies on MCI progression are important for Alzheimer’s disease (AD) prevention. 18F fluoro-deoxy-glucose positron emission tomography (FDG-PET) has been proven to be a powerful tool measuring cerebral glucose metabolism. In this study, we proposed classification framework prediction with both baseline multiple follow-up FDG-PET scans as well scores of 33 progressive (pMCI)...
The preparation and investigation of sustained-release risperidone-encapsulated microspheres using erodible poly(D, L-lactide-co-glycolide) (PLGA) lower molecular weight were performed compared to that commercial Risperdal Consta™ for the treatment schizophrenia. research included screening optimizing suitable polymers PLGA50/50 or blends these PLGA prepare with zero-order release kinetics properties. Solvent evaporation method was applied here while studies risperidone loaded microsphere...
Ginseng fruit saponins (GFS) extracted from the ginseng are bioactive triterpenoid saponin components. The aim of present study was to develop a drug delivery system called proliposome using sodium deoxycholate (NaDC) as bile salt improve oral bioavailability GFS in rats. liposomes were prepared by conventional ethanol injection and formed solid proliposomes (P-GFS) spray drying method on mannitol carriers. formulation P-GFS optimized response surface methodology. physicochemical properties...