A5028445129- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
- Nanoplatforms for cancer theranostics
- Dermatology and Skin Diseases
- Advancements in Transdermal Drug Delivery
- RNA Research and Splicing
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Calpain Protease Function and Regulation
- Lipid Membrane Structure and Behavior
- Adenosine and Purinergic Signaling
- RNA regulation and disease
- Polymer Surface Interaction Studies
- Viral Infections and Vectors
The University of Texas MD Anderson Cancer Center
2023-2025
Korea Advanced Institute of Science and Technology
2017-2024
Sungkyunkwan University
2018-2024
Samsung (South Korea)
2018-2024
Institute for Basic Science
2022-2023
Samsung (United Kingdom)
2022
Abstract The recent success of mRNA therapeutics against pathogenic infections has increased interest in their use for other human diseases including cancer. However, the precise delivery genetic cargo to cells and tissues remains challenging. Here, we show an adaptive strategy that enables docking different targeting ligands onto surface mRNA-loaded small extracellular vesicles (sEVs). This is achieved by using a microfluidic electroporation approach which combination nano- milli-second...
Abstract Immunogenic cell death (ICD) is distinguished by the release of tumor‐associated antigens (TAAs) and danger‐associated molecular patterns (DAMPs). This has been studied in field cancer immunotherapy due to ability ICD induce antitumor immunity. Herein, endoplasmic reticulum (ER) stress‐mediated inducing fluorinated mitochondria‐disrupting helical polypeptides (MDHPs) are reported. The fluorination polypeptide provides a high structure potent anticancer ability. destabilizes...
Circular RNAs (circRNAs) play a critical role in colorectal cancer (CRC) progression, including metastasis. However, the detailed molecular mechanism is not fully understood.Differentially expressed circRNAs between primary KM12C and liver metastatic KM12L4 colon cells were identified by microarray. The expression of was measured semi-quantitative (semi-qPCR) real time-quantitative PCR (RT-qPCR). Metastatic potential invasive migratory abilities, metastasis examined transwell assays...
Perturbation of potassium homeostasis can affect various cell functions and lead to the onset programmed death. Although ionophores have been intensively used as an ion disturber, mechanisms death are unclear bioapplicability is limited. In this study, helical polypeptide-based developed induce endoplasmic reticulum (ER) stress-mediated apoptosis. The disturb then prolonged ER stress in cells. results oxidative environments that accelerate activation mitochondria-dependent Moreover,...
Even though chemotherapy regimens for treating cancer by inducing apoptosis are extensively utilized, their therapeutic effect is hindered multiple limitations. Thus, a combination of other types anticancer modalities urgently needed. Herein, tannic acid (TA)-Fe3+-coated doxorubicin (DOX)-encapsulated 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(poly(ethylene glycol))-2000] (ammonium salt) (DSPE-PEG) micelle (TFDD) apoptosis/ferroptosis-mediated immunogenic cell death (ICD)...
Abstract Malignant characteristics of cancers, represented by rapid cell proliferation and high metastatic potential, are a major cause cancer-related mortality. As multifunctional RNA-binding protein, heterogeneous nuclear ribonucleoprotein K (hnRNPK) is closely associated with cancer progression in various types cancers. In this study, we sought to identify hnRNPK-regulated long intergenic non-coding RNAs (lincRNAs) that play critical role the regulation malignancy. We found hnRNPK...
INTRODUCTION: Recent advancements in mRNA therapeutics have shown remarkable efficacy against pathogenic infections, prompting interest their application for other diseases, particularly cancer. However, one major challenge is the precise delivery of genetic material to specific cells and tissues. Extracellular vesicles like exosomes are emerging as promising carriers due favorable immunogenic profile, long circulatory half-life, ability cross biological barriers such blood-brain barrier,...
Current strategies for active targeting in the brain are entirely based on effective interaction of ligand with orthosteric sites specific receptors blood-brain barrier (BBB), which is highly susceptible to various pathophysiological factors and limits efficacy drug delivery. Here, we propose an allosteric targeted delivery strategy that targets classical BBB transmembrane by designing peptide ligands specifically bind their domains. This prevents competitive interference from endogenous...
The recent success of large language models (LLMs) in performing natural processing tasks has increased interest applying generative artificial intelligence (AI) to scientific research. However, a common problem LLMs is their tendency produce inaccurate and sometimes "hallucinated" outputs. Here, we established AI tool, NanoSafari, automatically extract knowledge from the biomedical nanoscience literature address queries. We developed Grouped Iterative Validation based Information Extraction...
Abstract UPF1, a novel posttranscriptional regulator, regulates the abundance of transcripts, including long noncoding RNAs (lncRNAs), and thus plays an important role in cell homeostasis. In this study, we revealed that UPF1 hepatocellular carcinoma upregulated EZH2-associated lncRNA (lncRNA-HEIH ) by binding CG-rich motif, thereby regulating (HCC) tumorigenesis. UPF1-bound lncRNA-HEIH was susceptible to degradation mediated phosphorylation via SMG1 SMG5. According analysis RNA-seq public...
Emerging ubiquitous wireless networks are being spread widely. Ubiquitous wearable computers (UWCs) which may contain various communication protocol modules such as WLAN, Bluetooth, ZigBee, Wibro, and CDMA can be a solution in this era to support the network environment. In environments, with multiple control each module coordinator communicate other devices containing WLAN ZigBee surrounding networks. Since IEEE802.15.4 IEEE802.11b share same 2.4 GHz ISM band, causes severe interference due...
Immunogenic cell death (ICD) is a key factor for generating antitumor immunity. Endoplasmic reticulum (ER) stress triggers the release of damage-associated molecular patterns (DAMPs), thus inducing immunogenicity. We developed polypeptide-based K+ ionophore that perturbed ion homeostasis and elicited prolonged ER stress. The not only fosters an oxidative environment activates mitochondria-dependent apoptosis pathways but also drives immune responses by releasing DAMPs. suppressed tumor...
Abstract Growing evidence indicates that long intergenic noncoding RNAs play an important role in cancer progression by affecting gene regulation at the transcriptional and posttranscriptional levels. Recent studies have shown RNA functions as a competitive endogenous RNA, which can interact with mitigate function of microRNA. In this study, we investigated molecular mechanism LINC00162 regulates cell proliferation apoptotic death. By analyzing sequencing data, was identified to be target...
Abstract Colorectal cancer (CRC) is the third most common diagnosed and second leading cause of cancer-related deaths. Emerging evidence has indicated that long non-coding RNAs (lncRNAs) are involved in progression various types cancer. In this study, we aimed to identify potential causal lncRNAs CRC through comprehensive multilevel bioinformatics analyses, coupled with functional validation. Our analyses identified LINC02257 as being highly expressed CRC, associated poor survival advanced...
In article number 2001308, Chae-Ok Yun, Yeu-Chun Kim, and co-workers develop endoplasmic reticulum (ER) stress-mediated immunogenic cell death (ICD) inducing fluorinated mitochondria-disrupting helical polypeptides (MDHPs). These destabilize the mitochondrial outer membrane, leading to overproduction of intracellular reactive oxygen species (ROS) ICD. addition, co-treatment MDHP anti-Programmed death-ligand 1 antibodies (αPD-L1), which block PD-L1 on tumor cell, significantly regresses...