A5007646187- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Kruppel-like factors research
- Genetic Syndromes and Imprinting
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Vitamin D Research Studies
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Advanced Biosensing Techniques and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- FOXO transcription factor regulation
- Colorectal and Anal Carcinomas
- Gallbladder and Bile Duct Disorders
- Inflammasome and immune disorders
Wuhan Sports University
2023-2025
The University of Texas MD Anderson Cancer Center
2003-2024
Soochow University
2024
Second Affiliated Hospital of Soochow University
2024
Fuzhou Maternity and Child Health Care Hospital
2024
Fujian Medical University
2024
Shanghai Sixth People's Hospital
2024
The First Hospital of Changsha
2024
Fudan University Shanghai Cancer Center
2004-2023
Nankai University
2023
Abstract KRAS mutations drive oncogenic alterations in numerous cancers, particularly human pancreatic ductal adenocarcinoma (PDAC). About 93% of PDACs have mutations, with G12D (∼42% cases) and G12V (∼32% being the most common. The recent approval sotorasib (AMG510), a small-molecule, covalent, selective KRASG12C inhibitor, for treating patients non–small cell lung cancer represents breakthrough targeted therapy. However, there is need to develop other much-needed KRAS-mutant inhibitors...
Abstract Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolded response (UPR), also determines cellular ferroptosis. Cancer and normal cells depleted of IRE1α gain resistance ferroptosis, while enhanced expression promotes Mechanistically, IRE1α’s endoribonuclease activity cleaves down-regulates mRNA key...
Tuberculosis (TB) is one of the oldest infectious diseases and continues to be a major killer human beings. This paper was designed provide insights into disease burden TB. The data retrieved downloaded from latest GBD database. Joinpoint regression done for temporal trend analysis. age-period-cohort model introduced get further independent effects age, period, cohort. BAPC utilized predict ASIR ASMR 2022 2036. From 1990 2021, ASPR dropped 31,446 (95% UI: 27,902 35,142) 30,557 27,693 33,531)...
Abstract Purpose: Musashi 2 (MSI2) is reported to be a potential oncoprotein in cases of leukemia and several solid tumors. However, its expression, function, regulation pancreatic ductal adenocarcinoma (PDAC) have yet demonstrated. Therefore, the current study, we investigated clinical significance biologic effects MSI2 expression PDAC sought delineate newly identified Krüppel-like factor 4 (KLF4)/MSI2 regulatory pathway. Experimental Design: association with multiple clinicopathologic...
// Dacheng Xie 1 , Jiujie Cui 2 Tian Xia 2,3 Zhiliang Jia Liang Wang Wenfei Wei Anna Zhu Yong Gao 1,2 Keping and Ming Quan Department of Oncology, Shanghai Tongji University Affiliated East Hospital, Shanghai, People's Republic China Gastroenterology, Hepatology Nutrition, The Texas MD Anderson Cancer Center, Houston, TX, USA 3 Changhai Second Military Medical University, Correspondence to: Quan, email: Xie, Keywords : TAZ, EMT, proliferation, metastasis, pancreatic cancer Received August...
Abstract The indigenous microbial milieu within tumorous tissues exerts a pivotal influence on the genesis and advancement of gastric cancer (GC). This investigation scrutinizes functions molecular mechanisms attributed to Prevotella intermedia in malignant evolution GC. Isolation P. from paired GC was undertaken. Quantification abundance 102 accomplished using quantitative real‐time PCR (qRT‐PCR). Assessment biological effects cells observed culture medium supernatant. Furthermore, protein...
Surgery is becoming more practical and effective than conservative treatment in improving the poor outcomes of patients with breast cancer liver metastasis (BCLM). However, there no generally acknowledged set standards for identifying BCLM candidates who will benefit from surgery. Between January 2011 September 2018, 67 female underwent partial hepatectomy were selected analysis present study. Prognostic factors after determined. Univariate multivariate analyses performed to identify...
There is a high prevalence of malnutrition in cancer patients, which seriously affects the anti-cancer therapy effect and outcomes, causing huge disease burden worldwide. Appropriate nutritional support important for prevention control. The aim this study was to explore development trends, hotspots, frontiers Medical Nutrition Therapy (MNT) on Cancer from bibliometric perspective, provide new insights future research clinic practices.The global literature MNT published between 1975 2022 were...
Objectives This study aimed to describe the temporal trends in prevalence and disability-adjusted life years (DALYs) of refractive disorders (RD) China globally from 1990 2021 provide predictions for next decade. Methods Utilizing open data Global Burden Disease database (2021), this conducted a comprehensive comparative analysis RD burden globally, including changes DALYs. Joinpoint regression was employed calculate annual percentage change, average its corresponding 95% confidence interval...
Our previous studies provided evidence that COMMD7 was associated with tumor progression in human solid cancer. Herein, we aimed to investigate its expression pattern, clinical significance, and biological function pancreatic ductal adenocarcinoma (PDAC). We found high specifically detected PDAC tissues cell lines. In addition, overexpression positively correlated histological differentiation node metastasis (TNM) stage. Patients had significantly poorer overall survival, an independent...
Pancreatic cancer is a highly lethal malignancy, and the majority of patients succumb to disease within 2 years. We evaluated role variants mitochondrial DNA haplogroups in predicting prognosis with pancreatic cancer. A total 24 single nucleotide polymorphisms were genotyped 990 After adjusting for covariates multiple comparisons, no association between any or survival was observed.
The tissue microarray technique is a powerful that can examine many clinical specimens in single slide. However, this requires specialized instrument for the construction of block. authors describe an alternative macroarray simultaneous analysis multiple on As example method, assembled 12 tumor samples from different paraffin blocks glass slide and then immunostained with hMLH1 antibody. This simple method does not need equipment should be efficient approach large-scale specimens.