A5085402319- Microplastics and Plastic Pollution
- Periodontal Regeneration and Treatments
- Nanoplatforms for cancer theranostics
- biodegradable polymer synthesis and properties
- Pulmonary Hypertension Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Recycling and Waste Management Techniques
- Silk-based biomaterials and applications
- Effects and risks of endocrine disrupting chemicals
- Hormonal and reproductive studies
- Phytochemistry and Biological Activities
- Estrogen and related hormone effects
- Pharmacological Effects of Natural Compounds
- Oral Health Pathology and Treatment
- Medicinal plant effects and applications
- Oral microbiology and periodontitis research
- Menopause: Health Impacts and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Plant Toxicity and Pharmacological Properties
- Lung Cancer Treatments and Mutations
- Sulfur Compounds in Biology
- Neonatal Respiratory Health Research
- Flavonoids in Medical Research
- Corneal Surgery and Treatments
- Dietary Effects on Health
Yonsei University
2009-2025
Yonsei University College of Dentistry
2022-2023
Yonsei University Dental Hospital
2023
Chung-Ang University
2016-2022
Seoul Veterans Hospital
2021
Dankook University
2018
Samsung (South Korea)
2009
The development of bioplastics is advancing globally to promote a sustainable society. In this study, we designed cellulosic dual-network address the need for materials with balanced mechanical properties and biodegradability. Cellulose was used as first network, second network functionalized enhance strength while preserving dynamic covalent moieties within were generated through dithiolane ring-opening polymerization. ultimate tensile flexural elongation controlled 8.8-193 MPa 3.3-32.5%,...
Plastic is produced, used, and accumulated exponentially. Humans can take it through the food chain, microplastics be potentially toxic to humans. In this study, we analyzed surface patterns of their effects on humans using polyvinyl chloride (PVC) acrylonitrile butadiene styrene (ABS). The analysis these will used as a standardized measurement method for microplastic detection an indicator impact environmental pollution caused by We have statistical analyze shape milled estimated local...
Nonalcoholic fatty liver disease (NAFLD) and gallstone (GD) are often found to coexist but the sequential relationship of NAFLD GD each other remains controversial. We prospectively evaluated bidirectional with GD. A cohort study was performed on Korean adults who underwent a health checkup were followed annually or biennially for mean 6.0 years. Fatty gallstones diagnosed by ultrasound. defined as hepatic steatosis ultrasonography in absence excessive alcohol use identifiable causes. The...
Nitric oxide (NO) plays a key role in several physiological functions such as inflammatory responses and immune regulation. However, despite its beneficial functions, the short half-life diffusion radius limit NO availability biomedical applications. Hence, controlled release is important to achieve desired therapeutic effects with exogenous delivery. In this study, we fabricated poly(lactic-co-glycolic acid) (PLGA)-based delivery system sustained manner under conditions. To prevent an...
Abstract The kinetic body motions have guided the core‐shell fabrics of wearable bioelectronics to be elastoplastic. However, polymeric electrodes follow trade‐off relationship between toughness and stretchability. To this end, stress dissipation encoded silk fibroin electrode is proposed as core bioelectronics. Significantly, high degree intrinsic realized via an amino acid crosslink. canonical phenolic (i.e., tyrosine) engineered bridge secondary structures. A sufficient crosslink network...
Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between host microbiome and cells, occurs in oral environment under normal, but not pathologic, conditions. Here, we develop symbiotically integrating membrane mimicking tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva vivo canine experiments to confirm that induces symbiotic...
The use of mesenchymal stem cells (MSCs) in regenerative medicine has gained considerable attention recent years with the development clinically relevant MSCs from induced pluripotent (iPSCs) and embryonic cells. Through sequential presentations appropriate growth factors (GFs), iPSCs can be differentiated into mesodermal then MSCs. Furthermore, formation 3-dimensional cell spheroids, known as embryoid bodies, used to mimic vivo conditions. However, compact nature bodies restricts efficient...
Personalized dendritic cell (DC) based vaccines offer promising immunotherapeutic approaches for cancers and infectious diseases by leveraging living DCs to stimulate a patient's immune system through interactions with T cells. However, conventional DC-based face significant challenges, including limited stability short storage lifespan of the To overcome these limitations, smart artificial nanorobots, termed nano-bone marrow (BMDC)-originated activators (nano-BOTs) are developed...
Abstract In this study, we immobilized enzymes by combining covalent surface immobilization and hydrogel entrapment. A model enzyme, glucose oxidase (GOX), was first covalently on the of silica nanoparticles (SNPs) via 3‐aminopropyltriethoxysilane (APTES), resultant SNP‐immobilized enzyme physically entrapped within photopolymerized hydrogels prepared from two different molecular weights (MWs) (575 8000 Da) poly(ethylene glycol)(PEG). The entrapment resulted in a decrease reaction rate an...
Objectives: This study evaluated radiographically the integration and volume maintenance of grafted autogenous block bone under various cortical perforation conditions in dogs. Material methods: Five mongrel dogs were used. Each dog received four differently prepared onlay grafts: a solid graft was fixed on either (1) cortically perforated recipient bed (SGPR) or (2) nonperforated (SGNPR), (3) (PGNPR) (4) (PGPR). The animals sacrificed at 1 day, 4 days, 10 weeks, 8 weeks after surgery....
In this study, we investigated the steroidogenic effect of Taraxacum officinale extract on mouse TM3 Leydig cells, which produce male hormones by increasing levels enzymes. Steroidogenic enzymes are involved in production testosterone testis. To date, T. has not been reported. Therefore, examined effects (TOE) cells vitro. Traditionally, plants have used for treatment various kinds ailments. For many years, some medicinal to regulate steroidogenesis or late-onset hypogonadism (LOH)....
Mangosteen and propolis extracts (MAEC) have been potential therapeutic agents known to exhibit powerful antioxidant anti-inflammatory properties. The aim of the current study was evaluate clinical immunological efficacy MAEC as well safety patient-reported outcomes (PROMs) on gingivitis incipient periodontitis.This performed 104 patients diagnosed with or periodontitis. At baseline, participants were randomly allocated either test group, daily intake a single capsule containing 194 mg for...
Abstract The delivery of nitric oxide (NO)—an intrinsic cellular signaling molecule—is promising for disease treatment, in particular to vascular diseases, due its endothelial‐derived inherent nature. limited diffusion distance labile NO prompts researchers develop various carriers and targeting methods specific sites. In contrast the apoptotic effect NO, such as anticancer, delivering low concentration at desired area is still intricate a physiological environment. this study,...
Microbiome from a "healthy cohort" is used as reference for comparison to cases and intervention. However, the studies with cohort-based clinical research have not sufficiently accounted multistability in oral microbial community. The screening limited phenotypic features marked variations genomic markers. Herein, we aimed assess stability of microbiome across time an intervention-free "healthy" cohort.We obtained 33 supragingival samples 11 healthy participants biobank. For each...
Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by epidermal barrier dysfunction and dysregulation of innate adaptive immunity. Epigenetic regulation human β-defensin-1 (HBD-1) might be associated with variety defects in the immune system during AD pathogenesis. We investigated possible mechanism decreased HBD-1 gene expression demonstrated restoration transcription undifferentiated normal keratinocyte cells after treatment DNA methyltransferase inhibitor. also conducted...
Abstract Brain Factor-7® (BF-7), silk fibroin peptide, is known to be effective in improvement of memory and learning ability. In this study, the effects BF-7 (10 mg/kg, p.o., pre-treatment for 7 days post-treatment days) on neuroprotection functions were investigated a rat model transient focal cerebral ischemia gerbil global forebrain ischemia. Furthermore, find mechanism BF-7, we examined neuroprotective antioxidative vitro using neuroblastoma (SH-SY5Y) cells. vivo model, treatment with...