A5101571126- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Gestational Diabetes Research and Management
- Growth Hormone and Insulin-like Growth Factors
- Immune Cell Function and Interaction
- Neuroblastoma Research and Treatments
- Cancer Risks and Factors
- Gastric Cancer Management and Outcomes
- Diabetes Management and Education
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- RNA Interference and Gene Delivery
- Magnesium in Health and Disease
- Peptidase Inhibition and Analysis
- Gout, Hyperuricemia, Uric Acid
- Trace Elements in Health
- Heart rate and cardiovascular health
- Educational Technology and Assessment
MacroGenics (United States)
2017-2024
Shanghai Jiao Tong University
2013-2017
Chinese Academy of Sciences
2013-2017
Shanghai Institutes for Biological Sciences
2013-2017
Ruijin Hospital
2013-2017
Shanghai Clinical Research Center
2013-2016
Tebotelimab, a bispecific PD-1×LAG-3 DART molecule that blocks both PD-1 and LAG-3, was investigated for clinical safety activity in phase 1 dose-escalation cohort-expansion trial patients with solid tumors or hematologic malignancies disease progression on previous treatment. Primary endpoints were maximum tolerated dose of tebotelimab when administered as single agent (n = 269) combination the anti-HER2 antibody margetuximab 84). Secondary included anti-tumor activity. In advanced cancer...
To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the Chinese population to identify factors that modify of among individuals metabolism.Between 2011 2012, 259 657 community-dwelling adults, aged 40 years older, were recruited from 25 centers across mainland China participant baseline survey REACTION study, follow-up investigations performed 3, 5, 10 later. Detailed questionnaires about lifestyles, physical...
Prolactin is a major stimulus for the β-cell adaptation during gestation and guards postpartum women against gestational diabetes. Most studies of role prolactin on glucose metabolism have been conducted in humans animals pregnancy. However, little known concerning association between circulating outside pregnancy epidemiological studies. We aimed to determine whether variation concentration associates with diabetes impaired regulation (IGR) cross-sectional study.We recruited 2,377...
Lipoprotein (a) [Lp(a)], an LDL-like particle, has been proposed as a causal risk factor for CVD among general populations. Meanwhile, both serum Lp(a) and diabetes increase the of CVD. However, relationship between T2D is poorly characterized, especially in Asian population. Therefore, we conducted cross-sectional study 10,122 participants aged 40 years or older Jiading District, Shanghai, China. Our found that prevalence was decreased from 20.9% to 15.0% lowest quartile highest...
To examine the association between depression and impaired glucose regulation, newly diagnosed diabetes previously in middle-aged elderly Chinese people, whether was associated with different treatment regimens or durations of diabetes.A cross-sectional study performed among 229,047 adults living community aged ≥ 40 years from 25 centres China. The self-reported rating scale Patient Health Questionnaire 9 (PHQ-9) used to diagnose probable sub-threshold depression. Glucose metabolism status...
Chronic kidney disease (CKD) increases cardiovascular (CVD) risk. However, the association of mildly reduced function with CVD risk is unclear.This study investigated estimated glomerular filtration rate (eGFR) prevalent CVDs, 10-year Framingham for coronary heart (CHD), and atherosclerotic diseases (ASCVD) in 239 832 participants from baseline Risk Evaluation cAncers Chinese diabeTic Individuals: a lONgitudinal study. With an interviewer-assisted questionnaire, we collected information on...
Abstract Deep coalbed methane (CBM) exploration presents unique challenges in reservoir characterization, particularly when dealing with thin coal seams. This study introduces a novel application of two-dimensional Convolutional Neural Network (2D CNN) based seismic impedance inversion for characterizing the No. 8 seam China's Ordos Basin. By integrating post-stack 3D data limited well log information, we achieve high-resolution across an 80 km² deep CBM block Daji area. The results...
Whether serum magnesium deficiency is independently associated with the prevalence of microalbuminuria still unclear. The objective present study was to elucidate association between and in diabetic patients. A cross-sectional conducted 1829 subjects (aged ≥ 40 years) from Shanghai, China. Subjects were divided into three groups according tertiles. first-voided early-morning spot urine sample obtained for urinary albumin-creatinine ratio (UACR) measurement. Microalbuminuria defined as...
Previous studies suggest that visceral fat is associated with type 2 diabetes (T2D) independent of body mass index (BMI). However, epidemiological data about the relationship between and T2D are rare in Chinese. The aim present study was to investigate whether area (VFA) beyond above BMI Chinese population.The community-based cross-sectional conducted 2013 on 4126 individuals (2545 women, 1581 men) aged ≥ 40 years, diagnosed according 1999 World Health Organization criteria. VFA measured by...
Background Micro-albuminuria has been well established as one of the risk factors metabolic syndrome (MetS). However, association MetS and its components with low-grade albuminuria among those normal urinary albumin excretion not clearly elucidated in Chinese population. Methodology Findings A cross-sectional study was conducted 9,579 participants excretion, who were recruited from Jia Ding District, Shanghai, China. The single-void first morning urine sample collected for creatinine...
Aim: The carotid intima-media thickness (CIMT) is now validated as a sensitive marker of atherosclerosis and directly associated with an increased risk cardiovascular disease. Considering that the independent association between serum uric acid level CIMT remains controversial due to complex interrelationship other known factors, further studies are needed. aim present study explore in general Chinese population determine whether differs according varied metabolic status.Methods: was...
Pairs of spouses share common lifestyle factors. In a cross-sectional analysis, we investigated whether diabetic individuals had higher prevalence diabetes and cardiometabolic disorders in community-based population Chinese adults aged 40 years or older between 2011 2012. A total 34,805 pairs were identified. All participants underwent standard oral glucose tolerance test provided detailed clinical, sociodemographic, information. Diabetes multiple defined according to criteria. Compared with...
Increasing evidence suggests that serum CA 19-9 is associated with abnormal glucose metabolism. However, data on the association between and metabolic syndrome limited. The aim of present study was to investigate syndrome.A cross-sectional conducted 3641 participants aged ≥40 years from Songnan Community, Baoshan District in Shanghai, China. Logistic regression analysis used evaluate syndrome.Multivariate logistic showed compared first tertile 19-9, those second third tertiles had increased...
Thyroid function and microalbuminuria are both associated with vascular disease endothelial damage. However, whether thyroid is not well established. The objective was to explore the relationship between hormones in Chinese population. A community-based cross-sectional study performed among 3,346 adults (aged ≥ 40 years). Serum free triiodothyronine (FT3), thyroxine (FT4), TSH (thyroid stimulating hormone) were determined by chemiluminescent microparticle immunoassay. single-void first...
Objective To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence type 2 diabetes mellitus (T2DM) after midlife. Methods This study included 120,666 middle‐aged and elderly, whose retrospectively self‐reported weight at 20 40 years measured height were available. BMI in between defined as early‐adulthood BMI, change. Results The odds ratio (OR) for T2DM associated an 1‐unit increment or was 1.08 (95% confidence interval (CI),...
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The diagnosis of diabetes has important clinic implications for the prevention and management cardiometabolic disorders. We aimed to investigate awareness, treatment control hypertension dyslipidemia in previously-diagnosed newly-diagnosed Chinese adult population.We conducted a cross-sectional survey nationally representative sample 98658 adults aged 18 years or older 2010, using complex, multistage, probability sampling design. Glycemic status were defined according 2010 American Diabetes...
The present study aimed to explore the association between autonomic dysfunction and measurements of atherosclerosis in a middle-aged elderly Chinese population. A population-based cross-sectional was performed Shanghai, China, from March August 2010, with 5076 participants included analysis. Autonomic function assessed by novel EZSCAN test based on sudomotor Carotid intima-media thickness (CIMT) measured using B-mode ultrasonography brachial-ankle pulse wave velocity (ba-PWV) an device....