A5100637346- MicroRNA in disease regulation
- Computational Drug Discovery Methods
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Congenital gastrointestinal and neural anomalies
- Artificial Intelligence in Healthcare
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Venous Thromboembolism Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Thyroid Disorders and Treatments
- Biomedical Text Mining and Ontologies
- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- Machine Learning in Healthcare
- Pharmaceutical studies and practices
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Immunotherapy and Biomarkers
- Neurogenetic and Muscular Disorders Research
- Electrospun Nanofibers in Biomedical Applications
Henan University of Science and Technology
2024-2025
Sichuan University
2011-2025
West China Hospital of Sichuan University
2025
BOE Technology Group (China)
2023-2025
Chengdu Women's and Children's Central Hospital
2025
University of Electronic Science and Technology of China
2025
Xijing Hospital
2015-2025
Air Force Medical University
2021-2025
Shandong University
2014-2024
Monash University
2024
Abstract Nanomaterial‐mediated ferroptosis has garnered considerable interest in the antibacterial field, as it invokes disequilibrium of ion homeostasis and boosts lipid peroxidation extra‐ intracellular bacteria. However, current ferroptosis‐associated strategies indiscriminately pose damage to healthy cells, ultimately compromising their biocompatibility. To address this daunting issue, work designed a precise bio‐heterojunction (F‐bio‐HJ) consisting Fe 2 O 3 , Ti C ‐MXene, glucose...
In a follow-up study, we determined the prevalence, incidence, and natural course of positive antithyroperoxidase antibodies (TPOAbs) antithyroglobulin (TgAbs) in general population examined influences iodine intake.The study was conducted Panshan, Zhangwu, Huanghua, regions with mildly deficient, more than adequate, excessive intake, respectively. Of 3761 unselected subjects who were enrolled at baseline, 3018 participated 5-yr study. Serum TSH, TPOAb, TgAb levels measured.Among prevalence...
Abstract Clear evidence shows that tumors could secrete microRNAs (miRNAs) via exosomes to modulate the tumor microenvironment (TME). However, mechanisms sorting specific miRNAs into are still unclear. In order study biological function and characterization of exosomal miRNAs, we performed whole-transcriptome sequencing in 59 patients’ whole-course cerebrospinal fluid (CSF) small extracellular vesicles (sEV) matched glioma tissue samples. The results demonstrate be divided exosome-enriched...
As one of the most common post-transcriptional modifications mRNAs and noncoding RNAs, N6-methyladenosine (m6A) modification regulates almost every aspect RNA metabolism. Evidence indicates that dysregulation m6A associated proteins contributes to glioblastoma (GBM) progression. However, function fat mass obesity-associated protein (FTO), an demethylase, has not been systematically comprehensively explored in GBM. Here, we found decreased FTO expression clinical specimens correlated with...
Abstract Renal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle arrest at G2/M. However, the HDAC isoforms and underlying mechanism that are involved G2/M of TECs remain unclear. Here, we find Hdac9 expression is significantly induced mouse fibrotic kidneys, especially proximal tubules, aristolochic acid nephropathy (AAN) or unilateral ureter obstruction (UUO). Tubule-specific deletion HDAC9 pharmacological inhibition TMP195 attenuates cell G2/M, then...
Abstract Glioma is the most common malignant tumor of central nervous system in adults. The microenvironment (TME) related to poor prognosis glioma patients. cells could sort miRNA into exosomes modify TME. And hypoxia played an important role this sorting process, but mechanism not clear yet. Our study was find miRNAs sorted and reveal process. Sequencing analysis patients cerebrospinal fluid (CSF) tissue showed that miR-204-3p tends be exosomes. suppressed proliferation through...
Abstract Background Multi‐omics features of cell‐free DNA (cfDNA) can effectively improve the performance non‐invasive early diagnosis and prognosis cancer. However, multimodal characterization cfDNA remains technically challenging. Methods We developed a comprehensive multi‐omics solution (COMOS) to specifically obtain an extensive fragmentomics landscape, presented by breakpoint characteristics nucleosomes, CpG islands, DNase clusters enhancers, besides typical methylation, copy number...
Accumulating evidence indicates that a small subset of cancer cells, termed the tumor-initiating cells or stem (CSCs), construct reservoir self-sustaining with characteristic ability to self-renew and maintain tumor mass. The CSCs play an important role in initiation, development, relapse, metastasis, ineffectiveness conventional therapies. CD47 is ligand for signal-regulatory protein-α expressed on phagocytic functions inhibit phagocytosis. This study was explore if expression mechanism...
With the increasingly available electronic medical records (EMRs), disease prediction has recently gained immense research attention, where an accurate classifier needs to be trained map input signals (e.g., symptoms, patient demographics, etc.) estimated diseases for each patient. However, existing machine learning-based solutions heavily rely on abundant manually labeled EMR training data ensure satisfactory results, impeding their performance in existence of rare that are subject severe...
Currently, the effect of inflammation on tumorigenesis and progression has been widely noted. As a member pattern recognition receptors, toll-like receptor 4 (TLR4) plays pivotal role in tumor immune microenvironment increasingly investigated. In present study, we evaluated TLR4 expression its association with programmed cell death ligand 1 (PD-L1) non-small lung cancer (NSCLC) tissues assessed predicting value postoperative outcome. A total 126 NSCLC patients receiving complete pulmonary...
Growing studies have focused on the role of microRNA-21 (miR-21) in glioma, thus our objective was to discuss effect M2 bone marrow-derived macrophage (BMDM)-derived exosomes (BMDM-Exos) shuffle miR-21 biological functions glioma cells by regulating paternally expressed gene 3 (PEG3).Seventy-one cases human tissues and 30 non-tumor normal brain were collected stored liquid nitrogen. PEG3 expression tested. The fasting venous blood patients healthy control centrifuged, then supernatant at -...
Intratumoral heterogeneity is the primary challenge in treatment of glioblastoma (GBM). The presence glioma stem cells (GSCs) and their conversion between different molecular phenotypes contribute to complexity heterogeneity, culminating preferential resistance radiotherapy. ARP2/3 (actin-related protein-2/3) complexes (ARPs) are associated with cancer migration, invasion differentiation, while implications ARPs phenotype radiotherapy GSCs remain unclear.We screened expression TCGA-GBM...
Previous studies have reported the effect of N7-methylguanosine (m7G) regulator methyltransferase like-1 protein (METTL1) in tumor initiation, metastasis, and chemosensitivity. However, relationship between METTL1 cancer immune infiltration is not validated prognostic significance pan-cancer remains unclear.Clinical parameters, including gender, age, lifetime, stage, treatment response were analyzed to evaluate METTL1. To level METTL1, activity was generated by single sample gene set...
Health insurance fraud is becoming more common and impacting the fairness sustainability of health system. Traditional detection primarily relies on recognizing established data patterns. However, with ever-expanding complex nature data, it difficult for these traditional methods to effectively capture evolving fraudulent activity tactics keep pace constant improvements innovations fraudsters. As a result, there an urgent need accurate flexible analytics detect potential fraud. To address...
Summary Objective The aim of the present study was to evaluate whether status iodine nutrition influences TSH concentration in a selected Chinese reference population according criteria proposed by National Academy Clinical Biochemistry (NACB) and regular thyroid ultrasonography, establish new interval based on wide variation populations, identify an optimal following up cohort with normal concentrations at baseline. Design conducted Panshan, Zhangwu Huanghua, regions mildly deficient, more...