A5100340295- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- Biosensors and Analytical Detection
- Cancer-related molecular mechanisms research
- 14-3-3 protein interactions
- Neurogenesis and neuroplasticity mechanisms
- Bacteriophages and microbial interactions
- Curcumin's Biomedical Applications
- Advancements in Transdermal Drug Delivery
- Tissue Engineering and Regenerative Medicine
- Bacterial Genetics and Biotechnology
- Cannabis and Cannabinoid Research
- Global Educational Reforms and Inequalities
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Biosensing Techniques and Applications
- Sirtuins and Resveratrol in Medicine
- Intergenerational and Educational Inequality Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Axon Guidance and Neuronal Signaling
Peking University
2025
Peking University Third Hospital
2025
Qingdao University of Science and Technology
2023-2024
Chimie Biologique pour le Vivant
2024
Nanjing Tech University
2024
Xiamen University
2023
Shanxi Agricultural University
2023
Shenyang Pharmaceutical University
2023
Tsinghua University
2013-2022
Hong Kong Polytechnic University
2022
Abstract Adhesion to many kinds of surfaces, including biological tissues, is important in fields but has been proved be extremely challenging. Furthermore, peeling from strong adhesion needed conditions, sometimes painful. Herein, a mussel inspired hydrogel developed achieve both and trigger‐detachment. The former actualized by electrostatic interactions, covalent bonds, physical interpenetration, while the latter triggered, on‐demand, through combining thixotropic supramolecular network...
Ubiquitin-specific protease 39(USP39) plays an important role in modulating pre-mRNA splicing and ubiquitin-proteasome dependent proteolysis as a member of conserved deubiquitylation family. Accumulating evidences prove that USP39 participates the development hepatocellular carcinoma (HCC). However, little is known about mechanism especially deubiquitinating target regulating (HCC) growth. Here, we promotes HCC cell proliferation migration by directly deubiquitin β-catenin, key molecular...
Abstract Background Multi‐omics features of cell‐free DNA (cfDNA) can effectively improve the performance non‐invasive early diagnosis and prognosis cancer. However, multimodal characterization cfDNA remains technically challenging. Methods We developed a comprehensive multi‐omics solution (COMOS) to specifically obtain an extensive fragmentomics landscape, presented by breakpoint characteristics nucleosomes, CpG islands, DNase clusters enhancers, besides typical methylation, copy number...
BRCA1 gene and carcinoembryonic antigen (CEA) are important markers of breast cancer, so accurate detection them is significant for early diagnosis cancer. In this study, a potential-resolved ratio electrochemiluminescence (ECL) biosensor using perylene diimide (PDI)-metal-organic framework DNA nanoflowers (NFs)-CdS quantum dots (QDs) was constructed CEA. Specifically, PDI-MOF CdS QDs can generate intense ECL signals only one coreactant, the procedure be effectively simplified. first...
Arachidin-1 [trans-4-(3-methyl-1-butenyl)-3,5,3',4'-tetrahydroxystilbene] is a polyphenol produced by peanut kernels during germination. The aim of the present study was to investigate mechanism underlying anti-inflammatory effect arachidin-1 in endothelial cells (ECs). results cell adhesion and western blotting assays demonstrated that attenuated tumor necrosis factor (TNF)-α-induced monocyte/EC intercellular molecule-1 (ICAM-1) expression. exert its inhibitory effects attenuation...
Background Abnormal DNA methylation has been observed in promoter regions of a number genes human alcoholics. It is unclear whether changes alcoholics result directly from alcohol consumption or predated the occurrence abuse dependence and altered influences gene expression. Methods We investigated ethanol ( EtOH )‐induced mouse serotonin receptor 3a Htr3a ). A 5‐day drinking‐in‐the‐dark paradigm was applied to 28 male outbred CD ‐1 mice (15 ‐drinking 13 water‐drinking). The S equenom M ass...
The aim of this study was to detect the association between microRNA-10b (miR-10b) expression level and prognosis in glioma patients. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis used measure miR-10b levels different-grade tissues normal brain tissues. relationship clinical pathological characteristics statistically analyzed. influence on survival patients also As a result, were significantly increased compared those (p < 0.001). And associated with advanced grade...
The skull provides protection and mechanical support, acts as a container for the brain its accessory organs. Some defects in can fatally threaten human life. Many efforts have been taken to repair skull, among which cranioplasty is most prominent technique. To injury, numerous natural artificial materials adopted by neurosurgeons. cranioprostheses tried past decades, from autoplast bioceramics. Neurosurgeons evaluating their advantages shortages through clinical practice. Among those...
Event Abstract Back to Microneedle-array patches loaded with hypoxia-sensitive vesicles for rapid glucose-responsive insulin delivery Jicheng Yu1, 2, Yuqi Zhang1, Yanqi Ye1, Davis Ranson1, Wujin Sun1, Frances S. Ligler1, John B. Buse3 and Zhen Gu1, 3 1 University of North Carolina at Chapel Hill State University, Joint Department Biomedical Engineering, United States 2 Hill, Division Molecular Pharmaceutics Center Nanotechnology in Drug Delivery, Eshelman School, School Medicine,...
Gut microbiota is the key controller of healthy aging. Hypertension and osteoarthritis (OA) are two frequently co-existing age-related pathologies in older adults. Both associated with gut dysbiosis. Hereby, we explore microbiome alteration Deoxycorticosterone acetate (DOCA)-induced hypertensive rat model. Captopril, an anti-hypertensive medicine, was chosen to attenuate joint damage. Knee joints were harvested for radiological histological examination; meanwhile, fecal samples collected 16S...
Event Abstract Back to Mineralized collagen biomaterial for reconstruction of cranial bone defects and its clinical applications Zhiye Qiu1, 2, Tianxi Song2*, Yuqi Zhang3 Xiumei Wang1 1 Tsinghua University, School Materials Science Engineering, China 2 Beijing Allgens Medical Technology Co., Ltd., 3 Yuquan Hospital, Department Neurosurgery, Introduction: Cranial result from congenital malformation, trauma, tumor, as well produced by trephination in craniotomy are common symptoms...
Objective To investigate effects of histone deacetylase 1 (HDAC1) gene silencing on proliferation and apoptosis pancreatic cancer cell line PaTu8988. Methods The PaTu8988 cells were cultured divided into control group (untreated), negative (treated with 30 nmol/L siRNA), low HDAC1 15 siRNA) high siRNA). real-time PCR Western blot used to detect the efficiency mRNA protein levels ,respectively, at 48 hours after transfection siRNA. Cell evaluated using counting kit flow cytometry,...
Objective To investigate the effects of trichostatin A (TSA) on cell proliferation and cycle in human gastric cancer line SGC-7901 vitro its mechanism. Methods cells were treated with 0.1, 0.5 2.0 μmol/L TSA for 24 hrs. Growth inhibition rates measured by MTT assay cycles detected flow cytometery (FCM). Expressions cyclin D1 p21 mRNA real-time PCR. Results The proliferations inhibited when groups treat or 3.52%±6.11%, 13.29%±4.13% 14.24%±2.80% ,respectively. percentage G0/G1 phase higher 0....