A5100630872- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Nuclear Receptors and Signaling
- CRISPR and Genetic Engineering
- Advanced Fluorescence Microscopy Techniques
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- Protein Structure and Dynamics
- Genomics and Chromatin Dynamics
- Crystallization and Solubility Studies
- Drug Transport and Resistance Mechanisms
- DNA Repair Mechanisms
- Advanced biosensing and bioanalysis techniques
- Coccidia and coccidiosis research
- Parasitic Infections and Diagnostics
- Autophagy in Disease and Therapy
- Machine Learning in Bioinformatics
- Ginkgo biloba and Cashew Applications
- Research in Cotton Cultivation
- HIV/AIDS drug development and treatment
- MicroRNA in disease regulation
Wenzhou Medical University
2014-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018-2025
Peking University
2014-2024
Yuhuangding Hospital
2016-2024
First Affiliated Hospital Zhejiang University
2010-2024
Beijing National Laboratory for Molecular Sciences
2020-2024
Center for Life Sciences
2024
Qingdao University
2019-2024
State Key Laboratory of Hybrid Rice
2022-2023
Wuhan University
2022-2023
Pd(II)-catalyzed enantioselective C–H activation of phenylacetic acids followed by an intramolecular C–O bond formation afforded chiral benzofuranones. This reaction provides the first example enantioselecctive functionalizations through Pd(II)/Pd(IV) redox catalysis.
Understanding the regulation of islet cell mass has important implications for discovery regenerative therapies diabetes. The liver plays a central role in metabolism and endocrine number, but liver-derived factors that regulate α-cell β-cell remain unidentified. We propose nutrient-sensing circuit between pancreas which glucagon-dependent control hepatic amino acid regulates mass. found glucagon receptor inhibition reduced catabolism, increased serum acids, induced proliferation an...
Abstract Herein, an environmentally friendly electrochemical approach is reported that takes advantage of the captodative effect and delocalization to generate nitrogen‐centered radicals (NCRs). By changing reaction parameters electrode material feedstock solubility, dearomatization enabled a selective dehydrogenative C−N versus N−N bond formation reaction. Hence, pyrido[1,2‐ ]benzimidazole tetraarylhydrazine frameworks were prepared through sustainable transition‐metal‐ exogenous...
Transpiration occurs through stomata. The alteration of stomatal apertures in response to drought stress is an important process associated with water use efficiency (WUE). Trehalose-6-phosphate phosphatase (TPP) family genes have been reported participate adjustment aperture. However, there no reports the trehalose metabolism pathway improving WUE, and upstream signalling modulating these not clear. Here, we demonstrate that a member TPP gene family, AtTPPI, confers resistance improves WUE...
Trace elements have been recognized to play an important role in the development of Parkinson's disease (PD). However, it is difficult precisely identify relationship between these and progression PD because insufficient number patients. In this study, quantifications selenium (Se), copper (Cu), iron (Fe) zinc (Zn) by atomic absorption spectrophotometry were performed plasma from 238 patients 302 controls recruited eastern China, which so far largest cohort for measuring levels elements. We...
Paroxetine, a selective serotonin reuptake inhibitor for counteracting depression, has been recently suggested as having role in prevention of dopaminergic neuronal degeneration substantia nigra, hallmark Parkinson's disease (PD). The pathogenesis this type neurological disorders often involves the activation microglia and associated inflammatory processes. Thus study we aimed to understand paroxetine elucidate underlying mechanism(s). BV2 primary microglial cells were pretreated with...
One of the major causes failure in chemotherapy for patients with human chronic myelogenous leukemia (CML) is acquisition multidrug resistance (MDR). MDR often associated overexpression drug efflux transporters ATP-binding cassette (ABC) protein family. Timosaponin A-III (TAIII), a saponin isolated from rhizome Anemarrhena asphodeloides, has previously demonstrated ability to suppress certain tumor processes and potential be developed as an anticancer agent. Nevertheless, TAIII reverse not...
Transition-metal sulfides are key cathode materials for thermal batteries used in military applications. However, it is still a big challenge to prepare with good electronic conductivity and stability. Herein, we rapidly synthesized Co-doped NiS2 micro/nanostructure using hydrothermal method. We found that the specific capacity of Ni1–xCoxS2 increases amount Co doping. Under current density 100 mA cm–2, Ni0.5Co0.5S2 was about 1565.2 As g–1 (434.8 mAh g–1) cutoff voltage 1.5 V. Owing small...
A range of protected γ-oxo-α-amino esters have been prepared in a highly regio- and stereoselective manner through the decarboxylative Mannich reaction β-keto acids with optically active N-tert-butanesulfinyl α-imino presence 3 mol % La(OTf)3 or 5 Y(OTf)3 at 20 °C. Preliminary mechanistic studies indicate that proceeds imine addition followed by decarboxylation.
Introduction Alien hand syndrome (AHS) is a rare apraxia that may arise from several neurological disorders including stroke. Given the uncommon symptoms, stroke with AHS as its main manifestation often results in diagnostic challenges and treatment delays. Case presentation We herein presented case of post-stroke caused by corpus callosum infarction. prescribed him aspirin, clopidogrel, atorvastatin memantine, his was remitted completely within 8 days. Conclusion cerebral infarction...
Adult stem cells (ASCs) capable of self-renewal and differentiation confer the potential tissues to regenerate damaged parts. Epigenetic regulation is essential for driving cell fate decisions by rapidly reversibly modulating gene expression programs. However, it remains unclear how epigenetic factors elicit ASC-driven regeneration. In this paper, we report that an RNA interference screen against 205 chromatin regulators identified 12 proteins ASC function regeneration in planarians....
An iron-catalyzed aryldifluoromethylation of activated alkenes has been developed, which is a rare example where cosolvent used to improve the yield along with Fenton's reagent.
Multidrug resistance (MDR) plays a pivotal role in human chronic myelogenous leukemia (CML) chemotherapy failure. MDR is mainly associated with the overexpression of drug efflux transporters ATP-binding cassette (ABC) proteins. Phosphoinositide 3-kinase (PI3K)/Akt signaling cascade involved phenotype and correlated multidrug 1 (MDR1)/P-glycoprotein (P-gp), resistance-associated protein (MRP1) breast cancer (BCRP) expression many malignancies. Homeobox (HOX) B4, member HOX gene family, has...
Compound 1 ((−)-gossypol) has been long known as a chemical anticancer agent. With its low water solubility and toxicity, it is not widely used commercial drug. To overcome these disadvantages, several novel derivatives of gossypol were designed, synthesized, analyzed. One the derivatives, compound 7 (6-aminopenicillanic acid sodium-gossypolone), was identified with great property, suggested by inducing dramatically decrease in Bcl-2 Bcl-xL protein expression level found vitro growth...
The mouse lymphoma assay (MLA) uses the thymidine kinase (Tk) gene of L5178Y/Tk+/−-3.7.2C cell line as a reporter to evaluate mutagenicity chemical and physical agents. MLA is recommended by both United States Food Drug Administration Environmental Protection Agency preferred in vitro mammalian mutation for genetic toxicology screening because it detects wide range alterations, including point mutations chromosomal mutations. However, specific types that can be detected need further...
A novel series of trifluoromethyl indoles have been designed, synthesized and evaluated for anti-HIV-1 activities.
Deamidation of therapeutic antibodies may result in decreased drug activity and undesirable changes pharmacokinetics immunogenicity. Therefore, it is necessary to monitor the deamidation levels [during storage] after vivo administration. Because complexity samples, immuno-affinity capture widely used for specific enrichment target antibody prior LC-MS. However, conventional use bead-based methods requires large sample volumes extensive processing steps. Furthermore, with automation...