A5101727258- Tissue Engineering and Regenerative Medicine
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Genetics, Aging, and Longevity in Model Organisms
- Acupuncture Treatment Research Studies
- Advanced biosensing and bioanalysis techniques
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Inflammatory Bowel Disease
- Endoplasmic Reticulum Stress and Disease
- Pharmacological Effects of Natural Compounds
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Liver Disease and Transplantation
- Electrospun Nanofibers in Biomedical Applications
- Toxin Mechanisms and Immunotoxins
- Organ Transplantation Techniques and Outcomes
- Advancements in Transdermal Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Diabetes Treatment and Management
- Wound Healing and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
Beijing Institute of Technology
2024
Soochow University
2024
Linyi People's Hospital
2019-2024
Hainan Medical University
2024
Chinese Academy of Sciences
2015-2024
Affiliated Hospital of Hangzhou Normal University
2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Institute of Biophysics
2009-2024
The Unfolded Protein Response of the endoplasmic reticulum (UPRER) controls proteostasis by adjusting protein folding capacity ER to environmental and cell-intrinsic conditions. In metazoans, loss results in degenerative proliferative diseases cancers. cellular molecular mechanisms causing these phenotypes remain poorly understood. Here we show that UPRER is a critical regulator intestinal stem cell (ISC) quiescence Drosophila melanogaster. We find ISCs require activation for regenerative...
Intestinal homeostasis requires precise control of intestinal stem cell (ISC) proliferation. In Drosophila, this declines with age largely due to chronic activation stress signaling and associated inflammatory conditions. An important contributor condition is the age-associated increase in endoplasmic reticulum (ER) stress. Here we show that PKR-like ER kinase (PERK) integrates both cell-autonomous non-autonomous stimuli induce ISC addition responding cell-intrinsic stress, PERK also...
Abstract Ulcerative colitis (UC) is associated with the shedding of gut mucus. Decellularized porcine small intestinal submucosa (SIS‐ECM) contains numerous active forms extracellular matrix as well growth factors. Herein, a mucus‐mimetic hydrogel (MAG) designed barrier therapy by integrating SIS‐ECM hyaluronic acid and epigallocatechin‐3‐gallate. MAG not only presented viscoelastic behaviors G' 4000 Pa but also good thixotropy. Moreover, physical shielding effective to hinder E. coli...
To examine the role of acupuncture in treatment diabetic painful neuropathy (DPN) using a single-blind, placebo-controlled RCT and to collect data that would be required future definitive study efficacy DPN.45 patients were allocated receive 10-week course either real (53%) or sham (47%) acupuncture. Five standardised points on lower limb each leg used study: LR3, KI3, SP6, SP10 ST36. Outcome measures included Leeds Assessment Neuropathic Symptoms Signs (LANSS) scale, pain (Visual Analogue...
Dietary restriction (DR) is one of the most robust lifespan-extending interventions in animals. The beneficial effects DR involve a metabolic adaptation toward increased triglyceride usage. regulatory mechanism and tissue specificity this switch remain unclear. Here, we show that IRE1/XBP1 endoplasmic reticulum (ER) stress signaling module mediates upon flies by promoting synthesis accumulation enterocytes (ECs) Drosophila midgut. Consistently, function ECs required for longevity DR. We...
No standard chemotherapy is available for patients with advanced esophageal squamous cell carcinoma (ESCC) who have failed prior first-line chemotherapy. The aim of this study was to evaluate the efficacy and safety apatinib, an oral VEGFR-2 inhibitor, as salvage treatment ESCC.After apatinib dosing, toxicity were evaluated in 62 pretreated ESCC from 2014 2016 at Zhejiang Cancer Hospital. In addition, survival analysis performed by Kaplan-Meier method.Among patients, 15 achieved partial...
Decellularized extracellular matrix (dECM) has been considered as a promising scaffold in xenotransplantation, yet natural tissue dECM is often mechanically weak and rapidly degraded, compromising the outcomes. How to restore mechanical strength optimise vivo degradation, but maintain microstructure maximumly suppress immune rejection, remains challenging. For this aim, we prepared characterised various crosslinked decellularized rabbit uterus (dUECM) evaluated performance after...
Repair of the intestinal epithelium is tightly regulated to maintain homeostasis. The response after epithelial damage needs be local and proportional insult. How different types are coupled repair remains incompletely understood. We report that distinct damage, IL-1R1 signaling in GREM1+ mesenchymal cells increases production R-spondin 3 (RSPO3), a Wnt agonist required for stem cell self-renewal. In parallel, regulates IL-22 by innate lymphoid promotes hyperplasia regeneration. Although...
EpCAM is expressed at low levels in a variety of normal human epithelial tissues, but overexpressed 70–90% carcinomas. From clinico-pathological point view, this has both prognostic and therapeutic significance. was first suggested as target for the treatment cancers 1990s. However, following several immunotherapy trials, results have been mixed. It that due, least part, to an unknown level expression tumors being targeted. Thus, selection patients who would benefit from by determining...
Secretory granules, also known as dense core vesicles, are generated at the trans-Golgi network and undergo several maturation steps, including homotypic fusion of immature secretory granules (ISGs) processing prehormones to yield active peptides. The molecular mechanisms governing granule largely unknown. Here, we investigate a highly conserved protein named HID-1 in mouse model. A conditional knockout pancreatic β cells leads glucose intolerance remarkable increase serum proinsulin/insulin...
Keratinocyte growth factor (KGF) has a good therapeutic effect on injured corneas.
Background. Islet transplantation is a promising option for the treatment of type 1 diabetes. However, current lack practical techniques isolated islets preservation still hampers advancement life-saving islet transplantation. suffers from internal or external stimuli–induced oxidative stress and subsequent inflammation during preservation, which leads to disappointing outcomes regarding yield, survival, function. Reactive oxygen species (ROS) overproduction primary cause that induces loss...
Abstract Background 'Kuerlexiangli’ ( Pyrus sinkiangensis Yu), a native pear of Xinjiang, China, is an important agricultural fruit and primary export to the international market. However, with persistent calyxes affect shape quality. Although several studies have looked into physiological aspects calyx abscission process, underlying molecular mechanisms remain unknown. In order better understand basis process abscission, materials at three critical stages regulation, 6000 × Flusilazole plus...