A5049497710- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Cyclopropane Reaction Mechanisms
- Catalytic Alkyne Reactions
- Phosphorus compounds and reactions
- Advanced Synthetic Organic Chemistry
- Chemical synthesis and alkaloids
- Cyclization and Aryne Chemistry
- Oxidative Organic Chemistry Reactions
- Synthesis of Indole Derivatives
- Traditional and Medicinal Uses of Annonaceae
- Radical Photochemical Reactions
- Nanocluster Synthesis and Applications
- Multicomponent Synthesis of Heterocycles
- Advanced Nanomaterials in Catalysis
- Crystallography and molecular interactions
Hefei National Center for Physical Sciences at Nanoscale
2017-2025
University of Science and Technology of China
2016-2025
Chinese Academy of Sciences
1999-2021
Shanghai Institute of Organic Chemistry
1999-2021
Hefei University
2015-2021
Wuhan Engineering Science & Technology Institute
2016
Shanghai Institute of Materia Medica
2016
Vertex Pharmaceuticals (United States)
2007-2015
Southern University of Science and Technology
2014
State Key Laboratory of Synthetic Chemistry
2007-2012
Insights into the role played by modified cinchona alkaloids in Sharpless asymmetric dihydroxylation inspired studies of as chiral organic catalysts that lead to development highly enantioselective alcoholyses for desymmetrization, kinetic resolution, and dynamic resolution cyclic anhydrides, cyanation ketones, 1,4-addition thiols cylic enones. These demonstrate potential broadly useful synthesis.
New S in town: Sulfonyl hydrazides smoothly undergo sulfenylation with indoles the presence of 10 mol % I2 to give structurally diverse indole thioethers moderate excellent yields extremely high regioselectivity. This study paves way for use sulfonyl as unique sulfur electrophiles chemical synthesis. As a service our authors and readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited...
The development of broadly applicable and practical catalytic approaches for the enantioselective creation quaternary stereocenters remains a highly desirable yet challenging goal. In this Communication, we describe cyanosilylation acetal ketones (α,α-dialkoxy ketones) catalyzed by modified cinchona alkaloids. This reaction is first an organic chiral Lewis base found to be efficient with bearing broad range alkyl, aryl, alkenyl, alkynyl substituents. new asymmetric reaction, coupled...
The NH2 group in primary allylic amines was substituted directly by sulfinate salts with excellent regio- and stereoselectivities. In the presence of 0.1 mol % [Pd(allyl)Cl]2, 0.4 1,4-bis(diphenylphosphino)butane (dppb), excess boric acid, a range α-unbranched were smoothly sodium sulfinates an α-selective fashion to give structurally diverse sulfones good yields exclusive E selectivity. Replacing dppb 1,1′-bi-2-naphthol (BINOL) allowed unsymmetric α-chiral be transformed into corresponding...
The Wittig reaction involving direct olefination of triphenylphosphonium ylides (Ph3P═CHR) with aldehydes is arguably the most often used method for alkene synthesis, but in general it yields mixtures Z- and E-alkenes semistabilized (R = aryl or vinyl). We have developed a simple efficient protocol to improve stereoselectivity significantly by replacing N-sulfonyl imines, which possess distinct electronic steric properties relative aldehydes. A broad range aromatic, α,β-unsaturated,...
An unprecedented protocol has been developed for the regioselective synthesis of structurally diverse indene derivatives from readily accessible N-benzylic sulfonamides and disubstituted alkynes through FeCl3-catalyzed cleavage sp3 carbon−nitrogen bonds to generate benzyl cation intermediates. In presence 10 mol % FeCl3, a broad range smoothly react with internal alkynes, alkynylcarbonyl compounds, alkynyl chalcogenides, or halides afford various functionalized extremely high regioselectivity.
An unprecedented three-component oxysulfenylation reaction of alkenes with sulfonyl hydrazides and alcohols has been developed in the presence 20 mol% iodine to give a range structurally diverse β-alkoxy sulfides good excellent yields.
A useful source: Arylsulfonyl hydrazides have been identified as synthetically aryl sources for the Pd(OAc)2 catalyzed oxidative Mizoroki–Heck-type reaction under molecular oxygen to provide a convenient access polysubstituted alkenes in highly regio- and stereoselective manner (see scheme). The well tolerates various functional groups such alkoxy, halo, alcohol, carboxylic acid, ester, amide, sulfonamide, sulfone.
Abstract A highly efficient strategy for the kinetic resolution of axially chiral BINAM derivatives involving a Brønsted acid‐catalyzed imine formation and transfer hydrogenation cascade process was developed. The provides convenient route to in high yields with excellent enantioselectivities.
Neue Schwefelquelle: Sulfonylhydrazide reagieren in Gegenwart von 10 Mol-% I2 bereitwillig mit Indolen und ergeben eine Bandbreite Indolthioethern hoher Regioselektivität. Diese Reaktion ebnet den Weg zur Verwendung Sulfonylhydraziden als charakteristische Schwefel-Elektrophile der chemischen Synthese. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery, but not...
A range of highly enantioenriched primary allylic amines underwent palladium-catalyzed oxidative coupling with sulfonyl hydrazides open to air at room temperature give structurally diverse sulfones in moderate excellent yields retention ee.
An unprecedented catalyst-free alkylation of sulfinic acids with sulfonamides has been developed via sp(3) C-N bond cleavage at room temperature. In the absence external catalysts and additives, a wide variety N-benzylic N-allylic couple to give structurally diversified sulfones in moderate excellent yields. Furthermore, reaction N-(2-acyl)allylic provides convenient access trisubstituted allyl exclusive Z selectivity.
The acid-catalyzed benzylic and allylic alkylation of protic nucleophiles is fundamentally important for the formation carbon-carbon carbon-heteroatom bonds, it a formidable challenge amine derivatives to be used as alkylating agents. Herein we report highly efficient carbon sulfur with sulfonamides through double Lewis acid catalyzed cleavage sp(3) carbon-nitrogen bonds at room temperature. In presence catalytic amount inexpensive ZnCl(2)-TMSCl (TMSCl: chlorotrimethylsilane), 1,3-diketones,...
Abstract A highly regioselective halogenation reaction of symmetrical and unsymmetrical aromatic azo compounds has been developed at room temperature or 50 °C. In the presence 5 mol% palladium diacetate 0.5 equiv. p ‐toluenesulfonic acid, a range smoothly undergo monobromination with N ‐bromosuccinimide to give corresponding in good excellent yields >99:1 ortho ‐selectivity. This chemistry successfully extended compounds, whose electron‐richer aryl groups prefer be monobrominated....
A new strategy has been introduced to develop a catalytic asymmetric Pictet-Spengler-type reaction by replacing the aldehyde with an imine. range of 4-(2-aminoaryl)indoles smoothly undergo chiral phosphoric acid catalyzed imines at room temperature give structurally diverse indolo[3,4-cd][1]benzazepines in good excellent yields and ee.
While several therapeutic options exist, the need for more effective, safe, and convenient treatment a variety of autoimmune diseases persists. Targeting Janus tyrosine kinases (JAKs), which play essential roles in cell signaling responses can contribute to aberrant immune function associated with disease, has emerged as novel attractive approach development new disease therapies. We screened our compound library against JAK3, key kinase cells, identified multiple scaffolds showing good...
Abstract An unprecedented sulfenylation reaction of carbon‐boron bonds has been developed using sulfonyl hydrazides as sulfenyl sources. A range underwent tetrakis(acetonitrile)copper(I) tetrafluoroborate [Cu(CH 3 CN) 4 BF ]/2,2′‐bipyridine‐catalyzed with boronic acids under air to give structurally diverse thioethers in moderate good yields. Preliminary mechanistic studies show that are subjected decomposition into thiosulfonates and disulfides followed by formation carbon‐sulfur acids....
A novel nanocluster Au<sub>44</sub>(SC<sub>2</sub>H<sub>4</sub>Ph)<sub>32</sub> exhibiting high catalytic activity at low-temperature was synthesized by an oxidation–decomposition–recombination (ODR) process.
An unprecedented application of trifluoromethanesulfonyl hydrazides as trifluoromethylating agents has been demonstrated in two vicinal difunctionalization reactions terminal alkenes: the copper-catalyzed three-component chlorotrifluoromethylation arylakenes with TfNHNHBoc and NaCl tandem trifluoromethylation/cyclization N-arylacrylamides TfNHNHBoc. The proceeded presence inexpensive oxidants under mild conditions provided a range structurally diverse trifluoromethyl-containing compounds...
Although face-centered cubic (fcc), body-centered (bcc), hexagonal close-packed (hcp), and other structured gold nanoclusters have been reported, it was unclear whether with mix-packed (fcc non-fcc) kernels exist, the correlation between kernel packing properties of is unknown. A Au49 (2,4-DMBT)27 nanocluster a shell electron count 22 has now synthesized structurally resolved by single-crystal X-ray crystallography, which revealed that contains unique Au34 consisting one quasi-fcc-structured...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTPeeling the Core–Shell Au25 Nanocluster by Reverse Ligand-ExchangeMan-Bo Li†, Shi-Kai Tian‡, Zhikun Wu*†, and Rongchao Jin*§View Author Information† Key Laboratory of Materials Physics, Anhui Nanomaterials Nanotechnology, Institute Solid State Chinese Academy Sciences (CAS), Hefei, 230031, China‡ Department Chemistry, University Science Technology China, 230026, China§ Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United...